Toxicity of manufactured nanomaterials

Particuology, Год журнала: 2021, Номер 69, С. 31 - 48

Опубликована: Ноя. 30, 2021

Manufactured nanomaterials with unique properties have been extensively applied in various industrial, agricultural or medical fields. However, some of the identified to be closely related nanomaterial toxicity. The "nano-paradox" has aroused concerns over use and development nanotechnology, which makes it difficult for regulatory agencies regulate nanomaterials. key fulfilling proper regulation lies adequate understanding impact on nano-bio interactions. To this end, we start present work a brief introduction interactions at different levels. Based that, how toxicity-associated manufactured (i.e., size, shape, chemical composition, surface properties, biocorona formation, agglomeration and/or aggregation state, biodegradability) their toxicokinetics, cellular uptake, trafficking responses, toxicity mechanisms is deeply explored. Moreover, advanced analytical methods studying are introduced. Furthermore, current legislative frameworks nanomaterial-containing products regions countries presented. Finally, propose several challenges facing nanotoxicology field possible solutions shed light safety evaluation

Язык: Английский

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Surface Ligand Engineering Ruthenium Nanozyme Superior to Horseradish Peroxidase for Enhanced Immunoassay

Advanced Materials, Год журнала: 2023, Номер 36(10)

Опубликована: Апрель 22, 2023

Nanozymes have great potential to be used as an alternative natural enzymes in a variety of fields. However, low catalytic activity compared with limits their practical use. It is still challenging design nanozymes comparable counterparts terms the specific activity. In this study, surface engineering strategy employed improve Ru using charge-transferrable ligands such polystyrene sulfonate (PSS). PSS-modified nanozyme exhibits peroxidase-like up 2820 U mg

Язык: Английский

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Innovative strategies for photodynamic therapy against hypoxic tumor

Asian Journal of Pharmaceutical Sciences, Год журнала: 2023, Номер 18(1), С. 100775 - 100775

Опубликована: Янв. 1, 2023

Photodynamic therapy (PDT) is applied as a robust therapeutic option for tumor, which exhibits some advantages of unique selectivity and irreversible damage to tumor cells. Among which, photosensitizer (PS), appropriate laser irradiation oxygen (O2) are three essential components PDT, but the hypoxic microenvironment (TME) restricts O2 supply in tissues. Even worse, metastasis drug resistance frequently happen under condition, further deteriorate antitumor effect PDT. To enhance PDT efficiency, critical attention has been received by relieving hypoxia, innovative strategies on this topic continue emerge. Traditionally, supplement strategy considered direct effective relieve TME, whereas it confronted with great challenges continuous supply. Recently, O2-independent provides brand new can avoid influence TME. In addition, synergize other strategies, such chemotherapy, immunotherapy, photothermal (PTT) starvation therapy, remedy inadequate hypoxia conditions. paper, we summarized latest progresses development improve efficacy against were classified into O2-dependent synergistic therapy. Furthermore, deficiencies various also discussed envisage prospects future study.

Язык: Английский

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Recent advances in multi‐metallic‐based nanozymes for enhanced catalytic cancer therapy

BMEMat, Год журнала: 2023, Номер unknown

Опубликована: Сен. 19, 2023

Abstract Nanozymes have emerged as a promising alternative to natural enzymes, effectively addressing enzymes' inherent limitation. Versatility and potential applications of nanozyme span across various fields, with catalytic tumor therapy being one prominent area. This has sparked significant interest exploration in the utilization nanozymes for targeted cancer treatment. Recent advancements interdisciplinary research, nanotechnology, biotechnology, technology led emergence multi‐metallic‐based nanozymes, which exhibit tremendous further development. review focuses on investigating synergistic effects aiming enhance our understanding their activities facilitate broader applications. We comprehensively survey remarkable achievements synthesis, mechanisms, latest therapy. Furthermore, we identify current limitations prospects development new materials application novel technologies, along challenges associated underscores significance emphasizes need continued well impact realization breakthroughs

Язык: Английский

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Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Фев. 6, 2024

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.

Язык: Английский

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Biomedical potential of nanozymes: Harnessing redox enzyme mimicry for theranostic applications

Coordination Chemistry Reviews, Год журнала: 2024, Номер 517, С. 215937 - 215937

Опубликована: Июнь 15, 2024

Язык: Английский

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Precise Chemodynamic Therapy of Cancer by Trifunctional Bacterium-Based Nanozymes

ACS Nano, Год журнала: 2021, Номер 15(12), С. 19321 - 19333

Опубликована: Дек. 1, 2021

Chemodynamic therapy (CDT) destroys cancer cells by converting H2O2 or O2 into reactive oxygen species (ROS), but its therapeutic efficacy is restricted the antioxidant capacity of tumor. Previous solutions focused on strengthening nanodrugs with ability to increase ROS production weaken cells. Conversely, we here develop a mild nanodrug negligible side effects. Specifically, Au@Pt nanozyme decorated bacterial surface (Bac-Au@Pt) reported achieve precise CDT. Due tumor targeting bacteria and catalytic property under acidic conditions, this nanosystem can release effectively. In addition, interferon gamma released T specifically decreases intracellular reductants in cells, while having no obvious effect normal Therefore, low dose Bac-Au@Pt achieves satisfactory nontoxic even at their components. This enables CDT immunotherapy mutually benefit improve each other, providing promising strategy high anticancer usage.

Язык: Английский

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Mitochondria-targeting Type I AIE photosensitizer combined with H2S therapy: Uninterrupted hydroxyl radical generation for enhancing tumor therapy

Nano Today, Год журнала: 2022, Номер 46, С. 101620 - 101620

Опубликована: Сен. 22, 2022

Язык: Английский

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Manganese-doping titanium disulfide cascade nanobioreactors for sequential gas-sonodynamic strategy with immune checkpoint blockade therapy of cancer

Nano Today, Год журнала: 2022, Номер 46, С. 101585 - 101585

Опубликована: Авг. 17, 2022

Язык: Английский

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Enzyme-mimetic antioxidant nanomaterials for ROS scavenging: Design, classification, and biological applications

Coordination Chemistry Reviews, Год журнала: 2023, Номер 500, С. 215536 - 215536

Опубликована: Ноя. 4, 2023

Язык: Английский

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