Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 35(33)

Опубликована: Март 7, 2023

Abstract Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging still suffers from low response rates and immune‐related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic (SDT), as a non‐invasive treatment, received ever‐increasing attention especially treatment of deep‐seated tumors. Significantly, SDT can effectively induce immunogenic cell death trigger systemic anti‐tumor immune response, termed immunotherapy. The rapid development nanotechnology revolutionized effects with robust induction. As result, more innovative nanosonosensitizers synergistic modalities are established superior efficacy safe profile. In this review, recent advances immunotherapy summarized particular emphasis on how be explored harness for amplifying response. Moreover, current challenges field prospects its clinical translation also presented. It is anticipated that review provide rational guidance facilitate nanomaterials‐assisted immunotherapy, helping pave way next‐generation eventually achieve durable patients.

Язык: Английский

---

Oxygen‐Deficient Molybdenum Oxide Nanosensitizers for Ultrasound‐Enhanced Cancer Metalloimmunotherapy

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(9)

Опубликована: Янв. 2, 2023

Oxygen-deficient molybdenum oxide (MoOX ) nanomaterials are prepared as novel nanosensitizers and TME-stimulants for ultrasound (US)-enhanced cancer metalloimmunotherapy. After PEGylation, MoOX -PEG exhibits efficient capability US-triggered reactive oxygen species (ROS) generation glutathione (GSH) depletion. Under US irradiation, generates a massive amount of ROS to induce cell damage immunogenic death (ICD), which can effectively suppress tumor growth. More importantly, itself further stimulates the maturation dendritic cells (DCs) triggeres activation cGAS-STING pathway enhance immunological effect. Due robust ICD induced by SDT DC stimulated -PEG, combination treatment -triggered aCTLA-4 amplifies antitumor therapy, inhibits metastases, elicits immune responses defeat abscopal tumors.

Язык: Английский

---

Titanium‐Based Nanoarchitectures for Sonodynamic Therapy‐Involved Multimodal Treatments

Small, Год журнала: 2023, Номер 19(12)

Опубликована: Янв. 15, 2023

Sonodynamic therapy (SDT) has considerably revolutionized the healthcare sector as a viable noninvasive therapeutic procedure. It employs combination of low-intensity ultrasound and chemical entities, known sonosensitizer, to produce cytotoxic reactive oxygen species (ROS) for cancer antimicrobial therapies. With nanotechnology, several unique nanoplatforms are introduced sonosensitizers, including, titanium-based nanomaterials, thanks their high biocompatibility, catalytic efficiency, customizable physicochemical features. Additionally, developing sonosensitizers facilitates integration SDT with other treatment modalities (for example, chemotherapy, chemodynamic therapy, photodynamic photothermal immunotherapy), hence increasing overall results. This review summarizes most recent developments in tissue engineering using titanium mediated SDT. The synthesis strategies biosafety aspects Titanium-based also discussed. Finally, various challenges prospects its further development potential clinical translation highlighted.

Язык: Английский

---

A Multichannel Metabolic Pathway Interference Strategy for Complete Energy Depletion‐Mediated Cancer Therapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(19)

Опубликована: Янв. 18, 2024

Abstract Hydrogen sulfide (H 2 S) is being progressively integrated as an emerging inhibitor of the electron transport chain in energy interference‐based tumor therapy. However, metabolic reprogramming cancer cells causes both oxidative phosphorylation (OXPHOS) and glycolysis to occur simultaneously, which contributes ineffective therapeutic effect blocking a single pathway. To achieve complete suppression production, inorganic H S donor ZnS@ZIF‐8@CaP nanoparticle (ZSZC NP) carrying Ca Zn constructed for achieving simultaneous interference OXPHOS glycolysis. The core–shell ZSZC nanoparticles can break down microenvironment. This leads sustained release calcium overload disrupt normal functioning mitochondria by inhibiting expression cytochrome c causing damage mitochondrial membrane potential. Meanwhile, presence 2+ hinders typical process impeding lactate dehydrogenase glyceraldehyde‐3‐phosphate dehydrogenase. synchronous hampers supply cells. Additionally, expedite necrosis vivo inducing cellular acidification calcification. Therefore, this energy‐blocking strategy will completely deplete reserves provide new insights exploring bioenergetic inhibition treatment approach.

Язык: Английский

---

Doping Engineering of Piezo‐Sonocatalytic Nanocoating Confer Dental Implants with Enhanced Antibacterial Performances and Osteogenic Activity

Advanced Functional Materials, Год журнала: 2024, Номер 34(21)

Опубликована: Янв. 30, 2024

Abstract Rescuing dental implants from plaque‐induced infection and implementing effective plaque control methods in a limited oral environment pose challenges for modern dentistry. To address this issue, Al ion doped strontium titanate/titanium dioxide nanotubes (Al‐SrTiO 3 /TiO 2 nanotubes, Al‐STNT) are designed as an ultrasound‐responsive nanocoating immobilized on the Ti implant surface. Introducing 3+ ions into inorganic sonosensitive SrTiO heterojunction induces oxygen vacancies disrupts lattice of . By overcoming bandgap barrier through ultrasonic stimulated piezoelectric effect, Al‐STNT produces more reactive species (ROS). In sonodynamic therapy (SDT) process, stimulus abundant ROS efficiently disrupting bacteria biofilm inhibiting metabolism. Moreover, specific nanoscale coating endows with osteogenic activity, facilitating formation rigid osseointegration between surface alveolar bone. mimicking human rats, demonstrates optimal postimplant while retaining its antibacterial ability sonosensitizer. Thanks to portability ultrasound instrument stability implant‐based sonosensitizer, strategy presents attractive option patients self‐treat secure long‐term success their implants.

Язык: Английский

---

Endoplasmic Reticulum‐Targeting Iridium(III) Nanosonosensitizer Amplifies Immunogenic Cell Death for Boosted Tumor Sono‐Immunotherapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(26)

Опубликована: Фев. 27, 2024

Abstract Reactive oxygen species (ROS)‐induced endoplasmic reticulum (ER) stress in sonodynamic therapy (SDT) can elicit immunogenic cell death (ICD)‐initiated antitumor immunity for augmented sono‐immunotherapy. However, unsatisfactory activity and mediocre ER induction ability of sonosensitizers essentially restrict SDT efficacy ICD stimulation. Herein, a versatile ER‐targeting Iridium(III) nanosonosensitizer is developed as superior inducer boosted tumor An ingenious cholic acid (CA)‐functionalized sonosensitizer Ir‐CA well‐designed skillfully crosslinked with human serum albumin (HSA) to form HSA@Ir‐CA. With high stability, favorable tumor‐targeting ability, reduction‐responsiveness, HSA@Ir‐CA preferentially accumulates sites enhanced cellular uptake, followed by rapid disassembly responding intracellular reductive environment. The uncaged selectively accumulate precisely disrupt situ produced type I II ROS upon US irradiation high‐efficiency SDT. Moreover, the maximized eminently amplifies evoke robust systemic immunity, inhibiting growths primary/distant tumor, lung metastasis, recurrence. This combined immune checkpoint inhibitor (αPD‐L1) further achieves reinforced therapeutic outcome against immunologically “cold” tumor. study presents an effective paradigm optimize amplify ICD‐initiated responses

Язык: Английский

---

Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics

Biomaterials, Год журнала: 2023, Номер 303, С. 122391 - 122391

Опубликована: Ноя. 15, 2023

Язык: Английский

---

Liquid metal microspheres with an eddy-thermal effect for magnetic hyperthermia-enhanced cancer embolization-immunotherapy

Science Bulletin, Год журнала: 2023, Номер 68(16), С. 1772 - 1783

Опубликована: Июль 19, 2023

Язык: Английский

---

2D Piezoelectric BiVO₄ Artificial Nanozyme with Adjustable Vanadium Vacancy for Ultrasound Enhanced Piezoelectric/Sonodynamic Therapy

Small, Год журнала: 2023, Номер 19(36)

Опубликована: Май 1, 2023

Increasing the yield of reactive oxygen species (ROS) to enhance oxidative stress in cells is an eternal goal cancer therapy. In this study, BiVO4 artificial nanozyme developed with adjustable vanadium vacancy for ultrasound (US) enhanced piezoelectric/sonodynamic Under US excitation, vacancy-rich nanosheets (abbreviated Vv -r NSs) facilitate generation a large number electrons improve ROS yield. Meanwhile, mechanical strain imposed by irradiation makes NSs display typical piezoelectric response, which tilts conduction band be more negative and valance positive than redox potentials O2 /O2•- H2 O/·OH, boosting efficiency generation. Both density functional theory calculations experiments confirm that introduction cationic can sonodynamic effect. As expected, have better peroxidase enzyme catalytic glutathione depletion activities, resulting increased intracellular stress. This triple amplification strategy induced substantially inhibits growth cells. The work may open avenue achieve synergetic therapy introducing vacancy, broadening biomedical use materials.

Язык: Английский

---

H₂S-Reactivating Antitumor Immune Response after Microwave Thermal Therapy for Long-Term Tumor Suppression

ACS Nano, Год журнала: 2023, Номер 17(19), С. 19242 - 19253

Опубликована: Окт. 2, 2023

Microwave thermal therapy (MWTT) is one of the most potent ablative treatments known, with advantages like deep penetration, minimal invasion, repeatable operation, and low interference from bone gas. However, microwave (MW) not selective against tumors, residual tumors after incomplete ablation will generate immunosuppression, ultimately making prone to recurrence metastasis. Herein, a nano-immunomodulator (Bi-MOF-l-Cys@PEG@HA, BMCPH) proposed reverse immunosuppression reactivate antitumor immune effect through responsively releasing H2S in tumor cells for improving MWTT. Under MW irradiation, BMCPH mediate MWTT ablate release l-cysteine (l-Cys) react highly expressed cystathionine β-synthase H2S. The generated can inhibit accumulation myeloid-derived suppressor (MDSCs) promote expression cytotoxic T lymphocytes (CTLs). Moreover, Bi-MOF also scavenge reactive oxygen species (ROS), major means MDSCs-mediated further weaken immunosuppressive effect. Simultaneously, surface-covered HA gather CTLs around enhance response. This nano gas immunomodulator provides an idea sensitive tunable unstable molecules at sites. strategy response introduces direction reduce risk metastasis ablation.

Язык: Английский

---