Advanced Functional Materials,
Год журнала:
2022,
Номер
32(39)
Опубликована: Июль 14, 2022
Abstract
Radiotherapy
is
essential
for
treating
unresectable
or
metastatic
breast
cancer,
but
radiotherapy‐induced
tumor
cell
death
generates
small
extracellular
vesicles
(sEVs)
that
promote
regrowth
and
metastasis
following
treatment.
Here
cationic
nanosheets
with
a
high
sEVs‐binding
capacity
suppress
sEVs‐induced
radiotherapy
developed.
Molybdenum
disulfide
(MoS
2
)
monolayers
are
prepared
by
using
lithium
ions
as
intercalation
agents,
functionalized
polyamidoamine
(PAMAM)
dendrimers.
The
MoS
‐PAMAM
particles
exhibit
corrugated
sheet‐like
nanostructure
larger
surface‐to‐volume
ratio
than
spherical
PAMAM‐functionalized
particles,
resulting
in
greater
sEVs
binding
capacity.
Treatment
of
MDA‐MB‐231
human
cancer
cells
the
reduces
Toll‐like
receptor
activation
proliferation,
migration,
invasion
to
extent
treatment
PAMAM
nanoparticles.
In
mouse
4T1
model,
inhibition
after
nanoparticles,
demonstrating
potential
these
sEVs‐scavenging
improving
outcomes
patients.
work
reveals
pivotal
role
2D
materials
sEVs,
indicating
significance
nanoscale
geometry
developing
next‐generation
biomaterials.
Cells,
Год журнала:
2022,
Номер
11(19), С. 3065 - 3065
Опубликована: Сен. 29, 2022
Cell
type-specific
drug
delivery
is
a
straightforward
strategy
to
achieve
targeted
cancer
therapy
and
reduce
side
effects.
Hyaluronic
acid
(HA),
an
U.S.
Food
Drug
Administration
(FDA)-approved
biocompatible
carbohydrate
polymer,
has
been
extensively
employed
as
targeting
ligand
for
system
due
its
natural
ability
bind
tumor
cells
overexpressing
cluster
of
differentiation
44
(CD44)
receptors.
Here,
we
report
the
preparation
antitumor
efficacy
HA-coated
bovine
milk
exosomes
(HA-mExo)
tumor-specific
microRNA-204-5p
mimics
(miR-204).
The
exosome-based
formulation
was
prepared
with
miR-204
encapsulated
inside
lumen
HA
displayed
outside
membrane.
resultant
HA-mExo-miR204
able
specifically
target
CD44-positive
cells,
concomitant
increase
in
intracellular
uptake
miR-204.
Compared
uncoated
mExo-miR204
formulation,
showed
significantly
increased
both
vitro
vivo.
Importantly,
excellent
biocompatibility
did
not
cause
significant
systemic
toxicity.
Given
that
are
low-cost
highly
accessible
biogenic
materials
broad
biomedical
applications,
HA-decorated
can
be
proven
practical
RNA
drugs
therapy.
Analytical Chemistry,
Год журнала:
2023,
Номер
95(8), С. 4113 - 4121
Опубликована: Фев. 14, 2023
To
address
the
challenge
of
signal
production
and
separation
for
multiple
microRNA
(miRNA)
detection,
in
this
work,
a
"one-pot"
process
to
self-generate
distinguishable
fluorescent
probes
was
developed.
Based
on
long
short
probe
amplification
strategy,
generated
G-quadruplex
dye-free
can
be
separated
detected
by
high-performance
liquid
chromatography–fluorescence
platform.
The
free
hairpin
enriched
guanine
with
different
lengths
base
sequences
were
designed
could
opened
target
miRNAs
(miRNA-10b,
miRNA-21,
miRNA-210).
Cleaved
one-pot
after
duplex-specific
nuclease-based
cleavage,
detection
realized
one
run.
No
solid
nanomaterials
applied
assay,
which
avoided
blocking
column.
Moreover,
without
modification
expensive
fluorescein,
experimental
cost
greatly
reduced.
reaction
also
eliminated
tedious
preparation
steps
suggested
feasibility
automation.
limits
miRNA-10b,
miRNA-210
2.19,
2.20,
2.75
fM,
respectively.
Notably,
method
successfully
multiplex
serum
samples
from
breast
cancer
patients
within
30
min.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(35), С. 41743 - 41754
Опубликована: Авг. 23, 2023
Nanoparticle
(NP)-mediated
drug
delivery
systems
are
promising
for
treating
various
diseases.
However,
clinical
translation
has
been
delayed
by
a
variety
of
limitations,
such
as
weak
loading,
nonspecific
leakage,
lack
bioactivity,
and
short
blood
circulation.
These
issues
in
part
due
to
the
unsatisfactory
function
biomaterials
nanocarriers.
In
addition,
synthesis
procedures
carrier
materials,
especially
polymers,
were
usually
complicated
led
high
cost.
this
report,
bioactive
copolymer
hydroxy
acid
amino
acid,
poly(salicylic
acid-co-phenylalanine)
(PSP),
was
developed
first
time
via
one-step
rapid
facile
strategy.
The
PSP
could
self-assemble
into
NPs
(PSP-NPs)
co-load
relatively
hydrophilic
sphingosine
kinase
1
inhibitor
(PF543
HCl
salt
format)
highly
hydrophobic
paclitaxel
(PTX)
form
PF543/PTX@PSP-NPs
with
efficient
dual
loading.
Encouragingly,
showed
long
circulation,
good
stability,
tumor
accumulation,
leading
significantly
enhanced
therapeutic
effects
on
breast
cancer.
Furthermore,
additionally
suppress
lung
metastasis
cancer,
more
importantly,
PSP-NPs
themselves
nanocarriers
also
an
anti-breast
cancer
effect.
With
these
combined
advantages,
new
polymer
corresponding
will
provide
valuable
insights
development
functional
polymers
nanomedicines
important
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
15(1), С. 52 - 96
Опубликована: Сен. 14, 2024
Modern
oncology
is
rapidly
evolving,
driven
by
recent
advances
in
RNA-based
therapeutics.
As
new
emerging
cutting-edge
technology,
mRNA
vaccines
hold
excellent
promise
for
encoding
immunostimulatory
molecules,
tumor-associated
antigens,
neoantigens,
and
chimeric
antigen
receptors
T-cell
reprogramming.
RNA
interference
tools
enable
highly
effective
post-transcriptional
gene
silencing
that
has
progressed
towards
more
tailored
antitumor
treatments
targeting
key
molecular
players
tumor
progression
drug
resistance.
The
inherent
challenges
limitations
of
tools,
such
as
size,
low
stability
surface
charges
hindering
direct
cell
entry,
along
with
the
short
circulatory
half-life
rapid
clearance,
call
improved
delivery
systems
enabling
enhanced
delivery.
Nanoplatforms,
particularly
certain
types
lipid,
polymeric
nanoparticles
inorganic
nanoparticles,
provide
designed
means
to
address
cellular
uptake.
This
paper
explores
barriers
while
giving
insight
into
future
perspective
cancer
therapeutics
context
nanoplatforms
during
development.
