ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
11(1), С. 213 - 227
Опубликована: Дек. 23, 2024
Small
extracellular
vesicles
(sEVs)
are
promising
nanocarriers
for
drug
delivery
to
treat
a
wide
range
of
diseases
due
their
natural
origin
and
innate
homing
properties.
However,
suboptimal
therapeutic
effects,
attributed
ineffective
targeting,
limited
lysosomal
escape,
insufficient
delivery,
remain
challenges
in
effectively
delivering
cargo.
Despite
advances
sEV-based
systems,
conventional
approaches
need
improvement
address
low
drug-loading
efficiency
develop
surface
functionalization
techniques
precise
targeting
cells
interest,
all
while
preserving
the
membrane
integrity
sEVs.
We
report
an
enhanced
gene
system
using
multifunctional
sEVs
highly
efficient
siRNA
loading
delivery.
The
integration
chiral
graphene
quantum
dots
capacity
structural
Additionally,
escape
is
facilitated
by
functionalizing
with
pH-responsive
peptides,
fully
harnessing
inherent
effect
targeted
These
achieved
1.74-fold
increase
cytosolic
cargo
compared
unmodified
sEVs,
resulting
substantial
silencing
around
73%.
Our
approach
has
significant
potential
advance
order
accelerate
clinical
progress.
Phytotherapy Research,
Год журнала:
2023,
Номер
37(10), С. 4375 - 4397
Опубликована: Июль 11, 2023
Abstract
Cancer
is
the
most
common
cause
of
death
worldwide,
following
cardiovascular
diseases.
a
multifactorial
disease
and
many
reasons
such
as
physical,
chemical,
biological,
lifestyle‐related
factors.
Nutrition,
which
one
various
factors
that
play
role
in
prevention,
development,
treatment
types
cancer,
affects
immune
system,
characterized
by
disproportionate
pro‐inflammatory
signaling
cancer.
Studies
investigating
molecular
mechanisms
this
effect
have
shown
foods
rich
bioactive
compounds,
green
tea,
olive
oil,
turmeric,
soybean
significant
positively
changing
expression
miRNAs
involved
regulation
genes
associated
with
oncogenic/tumor‐suppressing
pathways.
In
addition
to
these
foods,
some
diet
models
may
change
specific
cancer‐related
different
ways.
While
Mediterranean
has
been
anticancer
effects,
high‐fat
diet,
methyl‐restricted
are
considered
negative
effects.
This
review
aims
discuss
effects
called
“immune
foods,”
models,
components
on
cancer
prevention
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 28, 2024
Malignancy
is
a
major
public
health
problem
and
among
the
leading
lethal
diseases
worldwide.
Although
current
tumor
treatment
methods
have
therapeutic
effect
to
certain
extent,
they
still
some
shortcomings
such
as
poor
water
solubility,
short
half-life,
local
systemic
toxicity.
Therefore,
how
deliver
agent
so
realize
safe
effective
anti-tumor
therapy
become
urgently
be
solved
in
this
field.
As
medium
of
information
exchange
material
transport
between
cells,
exosomes
are
considered
promising
drug
delivery
carrier
due
their
nano-size,
good
biocompatibility,
natural
targeting,
easy
modification.
In
review,
we
summarize
recent
advances
isolation,
identification,
loading,
modification
carriers
for
alongside
application
therapy.
Basic
knowledge
exosomes,
biogenesis,
sources,
characterization
methods,
also
introduced
herein.
addition,
challenges
related
use
vehicles
discussed,
along
with
future
trends.
This
review
provides
scientific
basis
exosome
systems
oncological
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(11)
Опубликована: Янв. 5, 2023
Abstract
Liver
fibrosis
is
a
progressive
pathological
process
induced
by
various
stimuli
and
may
progress
to
liver
cirrhosis
cancer.
Forsythiaside
A
(FA)
an
active
ingredient
extracted
from
traditional
Chinese
medicine
Forsythiae
Fructus
has
prominent
hepatoprotective
activities.
However,
the
unsatisfactory
pharmacokinetic
properties
restrict
its
clinical
application.
In
this
study,
nanocarrier
of
CD44‐specific
ligand
Hyaluronic
acid
(HA)‐modified
milk‐derived
exosomes
(mExo)
encapsulated
with
FA
(HA‐mExo‐FA)
developed.
As
result,
HA
modification
could
deliver
drug‐loaded
target
cells
form
specific
ligand‐receptor
interaction
CD44,
thus
improving
anti‐liver
effect
FA.
vitro
findings
indicate
that
HA‐mExo‐FA
inhibit
TGF‐
β
1‐induced
LX2
cell
proliferation,
reduce
α
‐SMA
collagen
gene
protein
levels,
promote
apoptosis
activated
cells.
vivo
results
demonstrate
improve
morphology
function
changes
in
zebrafish
larvae.
The
mechanism
be
attributed
inhibition
NLRP3‐mediated
pyroptosis.
addition,
on
TAA‐induced
increase
NLRP3
production
attenuated
inhibitor
MCC950.
Collectively,
study
demonstrates
promising
application
drug
delivery
high
specificity
provides
powerful
novel
platform
for
therapy.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 1, 2024
Abstract
Reperfusion
therapy
is
critical
for
saving
heart
muscle
after
myocardial
infarction,
but
the
process
of
restoring
blood
flow
can
itself
exacerbate
injury
to
myocardium.
This
phenomenon
known
as
ischemia-reperfusion
(MIRI),
which
includes
oxidative
stress,
inflammation,
and
further
cell
death.
microRNA-146a
(miR-146a)
play
a
significant
role
in
regulating
immune
response
has
been
studied
its
potential
impact
on
improvement
function
injury.
However,
delivery
miR-146a
specific
efficient
manner
remains
challenge
extracellular
RNAs
are
unstable
rapidly
degraded.
Milk
exosomes
(MEs)
have
proposed
ideal
platform
miRNA-based
they
protect
miRNAs
from
RNase
degradation.
In
this
study,
effects
containing
MEs
(MEs-miR-146a)
cardiac
were
examined
rat
model
MIRI.
To
enhance
targeting
MEs-miR-146a
site
injury,
ischemic
myocardium-targeted
peptide
IMTP
was
modified
onto
surfaces,
whether
could
exert
better
therapeutic
by
echocardiography,
indicators
levels
inflammatory
factors.
Furthermore,
expressions
mediated
NF-κB
signaling
pathway-related
proteins
detected
western
blotting
qRT-PCR
elucidate
mechanisms.
MiR-146
mimics
successfully
loaded
into
electroporation
at
square
wave
1000
V
voltage
0.1
ms
pulse
duration.
be
up-taken
cardiomyocytes
protected
cells
oxygen
glucose
deprivation/reperfusion
induced
damage
vitro.
Oral
administration
decreased
tissue
apoptosis
expression
factors
improved
The
level
myocardium
tissues
significantly
increased
MEs-miR-146a,
higher
than
that
group.
addition,
intravenous
injection
enhanced
heart,
function,
reduced
suppressed
inflammation
MIRI,
more
effective
treatment.
Moreover,
protein
IRAK1,
TRAF6
p-p65.
Therefore,
exerted
their
anti-inflammatory
effect
inhibiting
IRAK1/TRAF6/NF-κB
pathway.
Taken
together,
our
findings
suggested
may
promising
strategy
treatment
MIRI
with
outcome
modification
peptide,
expected
applied
clinical
practice
future.
Pharmacological Research,
Год журнала:
2023,
Номер
190, С. 106732 - 106732
Опубликована: Март 15, 2023
High
mobility
group
A
2
(HMGA2)
is
a
protein
that
modulates
the
structure
of
chromatin
in
nucleus.
Importantly,
aberrant
expression
HMGA2
occurs
during
carcinogenesis,
and
this
an
upstream
mediator
cancer
hallmarks
including
evasion
apoptosis,
proliferation,
invasion,
metastasis,
therapy
resistance.
targets
critical
signaling
pathways
such
as
Wnt/β-catenin
mTOR
cells.
Therefore,
suppression
function
notably
decreases
progression
improves
outcome
patients.
As
mainly
oncogenic,
targeting
by
non-coding
RNAs
(ncRNAs)
crucial
to
take
into
consideration
since
it
affects
function.
MicroRNAs
(miRNAs)
belong
ncRNAs
are
master
regulators
vital
cell
processes,
which
affect
all
aspects
hallmarks.
Long
(lncRNAs)
circular
(circRNAs),
other
members
ncRNAs,
mediators
miRNAs.
The
current
review
intends
discuss
importance
miRNA/HMGA2
axis
modulation
various
types
cancer,
mentions
lncRNAs
circRNAs,
regulate
mediators.
Finally,
we
effect
miRNAs
interactions
on
response
cells
therapy.
Regarding
role
regulation
cells,
considering
confirmed
interaction
between
one
miRNAs,
promising
could
be
subject
future
clinical
trial
experiments.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 8, 2024
As
extracellular
vesicle
(EV)-based
nanotechnology
has
developed
rapidly,
it
made
unprecedented
opportunities
for
nanomedicine
possible.
EVs
and
exosome-like
nanovesicles
(ELNVs)
are
natural
nanocarriers
with
unique
structural,
compositional,
morphological
characteristics
that
provide
excellent
physical,
chemical,
biochemical
properties.
In
this
literature,
we
examine
the
of
EVs,
including
how
they
administered
orally
their
therapeutic
activity.
According
to
current
examples
ELNVs
oral
delivery,
milk
plant
can
exert
effects
through
protein,
nucleic
acid,
lipid
components.
Furthermore,
several
methods
loading
drugs
into
exosomes
targeting
have
been
employed
investigate
capability.
Moreover,
discuss
as
potential
drug
carriers
role
disease
prevention
treatment
or
in
future.
conclusion,
issues
associated
development
from
sources
such
plants,
well
concerns
standardized
applications
these
discussed.
