Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110921 - 110921
Published: Feb. 1, 2025
Language: Английский
Cells, Journal Year: 2022, Volume and Issue: 11(19), P. 3065 - 3065
Published: Sept. 29, 2022
Cell type-specific drug delivery is a straightforward strategy to achieve targeted cancer therapy and reduce side effects. Hyaluronic acid (HA), an U.S. Food Drug Administration (FDA)-approved biocompatible carbohydrate polymer, has been extensively employed as targeting ligand for system due its natural ability bind tumor cells overexpressing cluster of differentiation 44 (CD44) receptors. Here, we report the preparation antitumor efficacy HA-coated bovine milk exosomes (HA-mExo) tumor-specific microRNA-204-5p mimics (miR-204). The exosome-based formulation was prepared with miR-204 encapsulated inside lumen HA displayed outside membrane. resultant HA-mExo-miR204 able specifically target CD44-positive cells, concomitant increase in intracellular uptake miR-204. Compared uncoated mExo-miR204 formulation, showed significantly increased both vitro vivo. Importantly, excellent biocompatibility did not cause significant systemic toxicity. Given that are low-cost highly accessible biogenic materials broad biomedical applications, HA-decorated can be proven practical RNA drugs therapy.
Language: Английский
Citations
33
Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 34(2), P. 107508 - 107508
Published: May 14, 2022
Language: Английский
Citations
31
Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(8), P. 4113 - 4121
Published: Feb. 14, 2023
To address the challenge of signal production and separation for multiple microRNA (miRNA) detection, in this work, a "one-pot" process to self-generate distinguishable fluorescent probes was developed. Based on long short probe amplification strategy, generated G-quadruplex dye-free can be separated detected by high-performance liquid chromatography–fluorescence platform. The free hairpin enriched guanine with different lengths base sequences were designed could opened target miRNAs (miRNA-10b, miRNA-21, miRNA-210). Cleaved one-pot after duplex-specific nuclease-based cleavage, detection realized one run. No solid nanomaterials applied assay, which avoided blocking column. Moreover, without modification expensive fluorescein, experimental cost greatly reduced. reaction also eliminated tedious preparation steps suggested feasibility automation. limits miRNA-10b, miRNA-210 2.19, 2.20, 2.75 fM, respectively. Notably, method successfully multiplex serum samples from breast cancer patients within 30 min.
Language: Английский
Citations
18
Injury, Journal Year: 2024, Volume and Issue: 55(4), P. 111410 - 111410
Published: Feb. 7, 2024
Language: Английский
Citations
7
Drug Discovery Today, Journal Year: 2023, Volume and Issue: 28(4), P. 103507 - 103507
Published: Jan. 21, 2023
Language: Английский
Citations
16
ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(35), P. 41743 - 41754
Published: Aug. 23, 2023
Nanoparticle (NP)-mediated drug delivery systems are promising for treating various diseases. However, clinical translation has been delayed by a variety of limitations, such as weak loading, nonspecific leakage, lack bioactivity, and short blood circulation. These issues in part due to the unsatisfactory function biomaterials nanocarriers. In addition, synthesis procedures carrier materials, especially polymers, were usually complicated led high cost. this report, bioactive copolymer hydroxy acid amino acid, poly(salicylic acid-co-phenylalanine) (PSP), was developed first time via one-step rapid facile strategy. The PSP could self-assemble into NPs (PSP-NPs) co-load relatively hydrophilic sphingosine kinase 1 inhibitor (PF543 HCl salt format) highly hydrophobic paclitaxel (PTX) form PF543/PTX@PSP-NPs with efficient dual loading. Encouragingly, showed long circulation, good stability, tumor accumulation, leading significantly enhanced therapeutic effects on breast cancer. Furthermore, additionally suppress lung metastasis cancer, more importantly, PSP-NPs themselves nanocarriers also an anti-breast cancer effect. With these combined advantages, new polymer corresponding will provide valuable insights development functional polymers nanomedicines important
Language: Английский
Citations
14
Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 36(1), P. 109766 - 109766
Published: March 13, 2024
Language: Английский
Citations
5
Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(11), P. 109576 - 109576
Published: Jan. 29, 2024
Language: Английский
Citations
4
Carbon, Journal Year: 2024, Volume and Issue: 223, P. 119022 - 119022
Published: March 6, 2024
Language: Английский
Citations
4
Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 4161 - 4183
Published: Jan. 1, 2024
Extracellular vesicles (EVs) are enclosed by a nanoscale phospholipid bilayer membrane and typically range in size from 30 to 200 nm.They contain high concentration of specific proteins, nucleic acids, lipids, reflecting but not identical the composition parent cell.The inherent characteristics variety EVs give them extensive unique advantages field cancer identification treatment.Recently, have been recognized as potential tumor markers for detection cancer.Aptamers, which molecules single-stranded DNA or RNA, demonstrate remarkable specificity affinity their targets adopting distinct tertiary structures.Aptamers offer various over protein counterparts, such reduced immunogenicity, ability convenient large-scale synthesis, straightforward chemical modification.In this review, we summarized biogenesis, sample collection, isolation, storage characterization, finally provided comprehensive survey analysis techniques that based on aptamers.
Language: Английский
Citations
4