Molecular Pharmaceutics,
Год журнала:
2023,
Номер
20(9), С. 4373 - 4386
Опубликована: Авг. 14, 2023
Ischemia
or
hypoxia
can
lead
to
pathological
changes
in
the
metabolism
and
function
of
tissues
then
various
diseases.
Timely
effective
blood
resuscitation
improvement
is
very
important
for
treatment
However,
there
a
need
develop
stable,
nontoxic,
immunologically
inert
oxygen
carriers
due
limitations
such
as
shortages,
different
types,
risk
transmitting
infections.
With
development
technologies,
based
on
hemoglobin
perfluorocarbon
have
been
widely
studied
recent
years.
This
paper
reviews
application
carriers.
The
design
was
analyzed,
their
substitutes
hypoxic
diseases
discussed.
Finally,
characteristics
future
research
ideal
were
prospected
provide
reference
follow-up
research.
Biomaterials Research,
Год журнала:
2022,
Номер
26(1)
Опубликована: Июль 6, 2022
Theranostic
nanoplatforms
integrating
diagnostic
and
therapeutic
functions
have
received
considerable
attention
in
the
past
decade.
Among
them,
hollow
manganese
(Mn)-based
are
superior
since
they
combine
advantages
of
structures
intrinsic
theranostic
features
Mn
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(9)
Опубликована: Янв. 2, 2023
Oxygen-deficient
molybdenum
oxide
(MoOX
)
nanomaterials
are
prepared
as
novel
nanosensitizers
and
TME-stimulants
for
ultrasound
(US)-enhanced
cancer
metalloimmunotherapy.
After
PEGylation,
MoOX
-PEG
exhibits
efficient
capability
US-triggered
reactive
oxygen
species
(ROS)
generation
glutathione
(GSH)
depletion.
Under
US
irradiation,
generates
a
massive
amount
of
ROS
to
induce
cell
damage
immunogenic
death
(ICD),
which
can
effectively
suppress
tumor
growth.
More
importantly,
itself
further
stimulates
the
maturation
dendritic
cells
(DCs)
triggeres
activation
cGAS-STING
pathway
enhance
immunological
effect.
Due
robust
ICD
induced
by
SDT
DC
stimulated
-PEG,
combination
treatment
-triggered
aCTLA-4
amplifies
antitumor
therapy,
inhibits
metastases,
elicits
immune
responses
defeat
abscopal
tumors.
Theranostics,
Год журнала:
2023,
Номер
13(5), С. 1571 - 1583
Опубликована: Янв. 1, 2023
Rationale:
Spatiotemporal
control
of
pyroptosis
has
a
profound
impact
on
cancer
immunotherapy.Owing
to
the
precise
spatiotemporal
and
reduction
in
side
effects
ultrasound
(US),
sonodynamic
therapy
(SDT)
is
expected
be
promising
mean
activate
pyroptosis.Furthermore,
pyroptosis-initiated
immune
response
can
amplified
by
enhanced
lymphocyte
infiltration
occurring
due
extracellular
matrix
(ECM)
depletion.Therefore,
it
highly
desirable
develop
sonodynamic-immunomodulatory
strategy
amplify
pyroptosis-mediated
tumor
immunotherapy
remodeling
microenvironment,
thereby
enhancing
immunotherapy.Methods:
We
reported
potent
based
sonosensitizer,
which
composed
LY364947-loaded
porous
coordination
network
(PCN-224)
camouflaged
with
red
blood
cell
(RBC)
membrane
evaluated
activation,
collagen
depletion,
immunocyte
infiltration,
adaptive
during
vitro
vivo.Results:
The
sonosensitizer
generated
reactive
oxygen
species
(ROS)
under
US
irradiation
initiated
caspase-3
apoptotic
signaling
pathway,
regarded
as
key
upstream
activator
gasdermin
E
(GSDME)-mediated
pyroptosis.During
subsequent
anti-tumor
mediated
pyroptosis,
LY364947
loosened
ECM
structure
via
resulting
T-lymphocyte
nearly
complete
eradication
tumors
mouse
model
formation
immunological
memory.
Conclusion:Our
findings
indicate
that
pyroptotic
exhibits
robust
efficacy
well
provides
novel
insights
into
role
immunology.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(12)
Опубликована: Фев. 2, 2024
Abstract
Due
to
the
presence
of
natural
neoantigens,
autologous
tumor
cells
hold
great
promise
as
personalized
therapeutic
vaccines.
Yet
cell
vaccines
require
multi‐step
production
that
frequently
leads
loss
immunoreactive
antigens,
causing
insufficient
immune
activation
and
significantly
hampering
their
clinical
applications.
Herein,
we
introduce
a
novel
whole‐cell
cancer
vaccine
by
cloaking
with
lipopolysaccharide‐decorated
manganese(II)‐phenolic
networks
(MnTA
nanocloaks)
evoke
tumor‐specific
response
for
highly
efficacious
synergistic
immunotherapy.
The
polyphenols
coordinate
Mn
2+
immediately
adhere
surface
individual
cells,
thereby
forming
nanocloak
encapsulating
neoantigens.
Subsequent
decoration
lipopolysaccharide
induces
internalization
dendritic
where
ions
are
released
in
cytosol,
further
facilitating
stimulator
interferon
genes
(STING)
pathway.
Highly
effective
suppression
was
observed
combining
nanocloaked
treatment
anti‐programmed
death
ligand
1
(anti‐PD‐L1)
antibodies‐mediated
checkpoint
blockade
therapy.
Our
work
demonstrates
universal
yet
simple
strategy
engineer
cell‐based
nanobiohybrid
system
enhanced
Abstract
Herein,
a
dual‐sensitizer
prodrug,
named
pro‐THPC,
has
been
designed
to
function
as
both
photosensitizer
and
sonosensitizer
prodrug
for
precise
antitumor
combination
therapy
with
minimized
skin
phototoxicity.
Pro‐THPC
could
be
activated
by
glutathione
(GSH)
release
the
dual‐sensitizer,
THPC,
which
simultaneously
switches
on
fluorescence
emission
combined
capabilities
of
photodynamic
(PDT)
sonodynamic
(SDT).
is
further
formulated
into
nanoparticles
(NPs)
water
dispersity
enable
in
vivo
applications.
In
imaging
shows
that
pro‐THPC
NPs
group
exhibits
significantly
higher
tumor‐to‐normal
tissue
ratio
(
T
/
N
)
=
5.2
±
0.55)
compared
“always
on”
THPC
2.9
0.47)
co‐administrated
GSH
synthesis
inhibitor
(buthionine
sulfoximine,
BSO)
3.2
0.63).
addition,
generation
dual‐sensitizer's
reactive
oxygen
species
(ROS)
effectively
confined
within
tumor
tissues
due
relatively
strong
correlation
between
ROS
emission.
studies
demonstrate
remarkable
efficacy
eradicate
tumors
through
PDT
SDT
while
reducing
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(44)
Опубликована: Июль 16, 2024
Abstract
Despite
its
effectiveness
in
exterminating
tumor
cells,
ferroptosis
is
seriously
hampered
by
the
high
expression
of
antioxidant
glutathione
(GSH)
and
inadequacy
endogenous
H
2
O
tumors.
Herein,
metal‐phenolic
nanoformulations
(FNCP
NFs)
composed
sonosensitizer
Chlorin
e6
(Ce6),
phenolic
GSH
consumer
naphthazarin,
Fe
3+
,
followed
modification
PEG2000,
are
strategically
designed
fabricated
for
ultrasound‐boosted
cells
through
triple
regulatory
pathways.
The
carrier‐free
FNCP
NFs
can
rapidly
dissociate
under
microenvironment
response
with
assistance
ultrasound,
releasing
2+
Ce6,
naphthazarin.
Ce6
capable
producing
singlet
oxygen
(
1
)
hydroxyl
radicals
·
OH)
ultrasound‐activated
sonodynamic
therapy
Fenton
reaction‐mediated
chemodynamic
(CDT),
respectively,
which
not
only
induce
apoptotic
cell
death
but
also
lead
to
effective
accumulation
lipid
peroxidation
(LPO),
resulting
ferroptosis.
Meanwhile,
released
naphthazarin
self‐cycling
valence
alternations
/Fe
promote
significant
decrease
intracellular
contents,
further
inducing
inactivation
peroxidase
4
(GPX4)
up‐regulation
LPO
levels,
eventually
realizing
synergistically
enhanced
This
facile
feasible
design
versatile
offers
a
new
strategy
effectively
improving
efficiency
multimodal
cancer
therapies.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(12)
Опубликована: Фев. 2, 2024
Abstract
Due
to
the
presence
of
natural
neoantigens,
autologous
tumor
cells
hold
great
promise
as
personalized
therapeutic
vaccines.
Yet
cell
vaccines
require
multi‐step
production
that
frequently
leads
loss
immunoreactive
antigens,
causing
insufficient
immune
activation
and
significantly
hampering
their
clinical
applications.
Herein,
we
introduce
a
novel
whole‐cell
cancer
vaccine
by
cloaking
with
lipopolysaccharide‐decorated
manganese(II)‐phenolic
networks
(MnTA
nanocloaks)
evoke
tumor‐specific
response
for
highly
efficacious
synergistic
immunotherapy.
The
polyphenols
coordinate
Mn
2+
immediately
adhere
surface
individual
cells,
thereby
forming
nanocloak
encapsulating
neoantigens.
Subsequent
decoration
lipopolysaccharide
induces
internalization
dendritic
where
ions
are
released
in
cytosol,
further
facilitating
stimulator
interferon
genes
(STING)
pathway.
Highly
effective
suppression
was
observed
combining
nanocloaked
treatment
anti‐programmed
death
ligand
1
(anti‐PD‐L1)
antibodies‐mediated
checkpoint
blockade
therapy.
Our
work
demonstrates
universal
yet
simple
strategy
engineer
cell‐based
nanobiohybrid
system
enhanced
RSC Advances,
Год журнала:
2024,
Номер
14(21), С. 14722 - 14741
Опубликована: Янв. 1, 2024
Manganese-based
nanomaterials
have
seen
rapid
development
in
chemodynamic
therapy
and
T
1
-enhanced
MRI
over
the
past
five
years,
holding
promising
prospects
various
combined
applications.
