Research Progress in Oxygen Carrier Design and Application DOI
Qingsong Ye, Deyuan Zheng,

Kaiyuan Chen

et al.

Molecular Pharmaceutics, Journal Year: 2023, Volume and Issue: 20(9), P. 4373 - 4386

Published: Aug. 14, 2023

Ischemia or hypoxia can lead to pathological changes in the metabolism and function of tissues then various diseases. Timely effective blood resuscitation improvement is very important for treatment However, there a need develop stable, nontoxic, immunologically inert oxygen carriers due limitations such as shortages, different types, risk transmitting infections. With development technologies, based on hemoglobin perfluorocarbon have been widely studied recent years. This paper reviews application carriers. The design was analyzed, their substitutes hypoxic diseases discussed. Finally, characteristics future research ideal were prospected provide reference follow-up research.

Language: Английский

Manganese-based hollow nanoplatforms for MR imaging-guided cancer therapies DOI Creative Commons
Shuang Liang, Guangfu Liao, Wenzhen Zhu

et al.

Biomaterials Research, Journal Year: 2022, Volume and Issue: 26(1)

Published: July 6, 2022

Theranostic nanoplatforms integrating diagnostic and therapeutic functions have received considerable attention in the past decade. Among them, hollow manganese (Mn)-based are superior since they combine advantages of structures intrinsic theranostic features Mn

Language: Английский

Citations

76
Oxygen‐Deficient Molybdenum Oxide Nanosensitizers for Ultrasound‐Enhanced Cancer Metalloimmunotherapy DOI

Yuanjie Wang,

Fei Gong, Zhihui Han

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(9)

Published: Jan. 2, 2023

Oxygen-deficient molybdenum oxide (MoOX ) nanomaterials are prepared as novel nanosensitizers and TME-stimulants for ultrasound (US)-enhanced cancer metalloimmunotherapy. After PEGylation, MoOX -PEG exhibits efficient capability US-triggered reactive oxygen species (ROS) generation glutathione (GSH) depletion. Under US irradiation, generates a massive amount of ROS to induce cell damage immunogenic death (ICD), which can effectively suppress tumor growth. More importantly, itself further stimulates the maturation dendritic cells (DCs) triggeres activation cGAS-STING pathway enhance immunological effect. Due robust ICD induced by SDT DC stimulated -PEG, combination treatment -triggered aCTLA-4 amplifies antitumor therapy, inhibits metastases, elicits immune responses defeat abscopal tumors.

Language: Английский

Citations

72
A type I AIE photosensitiser-loaded biomimetic nanosystem allowing precise depletion of cancer stem cells and prevention of cancer recurrence after radiotherapy DOI
Shipeng Ning, Tianfu Zhang, Meng Lyu

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 295, P. 122034 - 122034

Published: Feb. 1, 2023

Language: Английский

Citations

59
Sonodynamic-immunomodulatory nanostimulators activate pyroptosis and remodel tumor microenvironment for enhanced tumor immunotherapy DOI Creative Commons
Zhuang Chen, Weijing Liu,

Zuo Yang

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(5), P. 1571 - 1583

Published: Jan. 1, 2023

Rationale: Spatiotemporal control of pyroptosis has a profound impact on cancer immunotherapy.Owing to the precise spatiotemporal and reduction in side effects ultrasound (US), sonodynamic therapy (SDT) is expected be promising mean activate pyroptosis.Furthermore, pyroptosis-initiated immune response can amplified by enhanced lymphocyte infiltration occurring due extracellular matrix (ECM) depletion.Therefore, it highly desirable develop sonodynamic-immunomodulatory strategy amplify pyroptosis-mediated tumor immunotherapy remodeling microenvironment, thereby enhancing immunotherapy.Methods: We reported potent based sonosensitizer, which composed LY364947-loaded porous coordination network (PCN-224) camouflaged with red blood cell (RBC) membrane evaluated activation, collagen depletion, immunocyte infiltration, adaptive during vitro vivo.Results: The sonosensitizer generated reactive oxygen species (ROS) under US irradiation initiated caspase-3 apoptotic signaling pathway, regarded as key upstream activator gasdermin E (GSDME)-mediated pyroptosis.During subsequent anti-tumor mediated pyroptosis, LY364947 loosened ECM structure via resulting T-lymphocyte nearly complete eradication tumors mouse model formation immunological memory. Conclusion:Our findings indicate that pyroptotic exhibits robust efficacy well provides novel insights into role immunology.

Language: Английский

Citations

44
Metal‐Phenolic Nanocloaks on Cancer Cells Potentiate STING Pathway Activation for Synergistic Cancer Immunotherapy DOI

Xianglian He,

Guidong Gong, Mei Chen

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(12)

Published: Feb. 2, 2024

Abstract Due to the presence of natural neoantigens, autologous tumor cells hold great promise as personalized therapeutic vaccines. Yet cell vaccines require multi‐step production that frequently leads loss immunoreactive antigens, causing insufficient immune activation and significantly hampering their clinical applications. Herein, we introduce a novel whole‐cell cancer vaccine by cloaking with lipopolysaccharide‐decorated manganese(II)‐phenolic networks (MnTA nanocloaks) evoke tumor‐specific response for highly efficacious synergistic immunotherapy. The polyphenols coordinate Mn 2+ immediately adhere surface individual cells, thereby forming nanocloak encapsulating neoantigens. Subsequent decoration lipopolysaccharide induces internalization dendritic where ions are released in cytosol, further facilitating stimulator interferon genes (STING) pathway. Highly effective suppression was observed combining nanocloaked treatment anti‐programmed death ligand 1 (anti‐PD‐L1) antibodies‐mediated checkpoint blockade therapy. Our work demonstrates universal yet simple strategy engineer cell‐based nanobiohybrid system enhanced

Language: Английский

Citations

22
Nano-ROS-generating approaches to cancer dynamic therapy: Lessons from nanoparticles DOI
Qinyi Zhang, Qiuhua Luo, Zimeng Liu

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 457, P. 141225 - 141225

Published: Dec. 29, 2022

Language: Английский

Citations

54
A GSH‐Responsive Prodrug with Simultaneous Triple‐Activation Capacity for Photodynamic/Sonodynamic Combination Therapy with Inhibited Skin Phototoxicity DOI

Caiting Deng,

Jingjing Zhang,

Fanchun Hu

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: June 5, 2024

Abstract Herein, a dual‐sensitizer prodrug, named pro‐THPC, has been designed to function as both photosensitizer and sonosensitizer prodrug for precise antitumor combination therapy with minimized skin phototoxicity. Pro‐THPC could be activated by glutathione (GSH) release the dual‐sensitizer, THPC, which simultaneously switches on fluorescence emission combined capabilities of photodynamic (PDT) sonodynamic (SDT). is further formulated into nanoparticles (NPs) water dispersity enable in vivo applications. In imaging shows that pro‐THPC NPs group exhibits significantly higher tumor‐to‐normal tissue ratio ( T / N ) = 5.2 ± 0.55) compared “always on” THPC 2.9 0.47) co‐administrated GSH synthesis inhibitor (buthionine sulfoximine, BSO) 3.2 0.63). addition, generation dual‐sensitizer's reactive oxygen species (ROS) effectively confined within tumor tissues due relatively strong correlation between ROS emission. studies demonstrate remarkable efficacy eradicate tumors through PDT SDT while reducing

Language: Английский

Citations

15
Tumor Microenvironment‐Activatable Metal‐Phenolic Nanoformulations for Ultrasound‐Boosted Ferroptosis through Triple Regulatory Pathways DOI

Zhendong Liu,

Sainan Liu,

Bin Liu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: July 16, 2024

Abstract Despite its effectiveness in exterminating tumor cells, ferroptosis is seriously hampered by the high expression of antioxidant glutathione (GSH) and inadequacy endogenous H 2 O tumors. Herein, metal‐phenolic nanoformulations (FNCP NFs) composed sonosensitizer Chlorin e6 (Ce6), phenolic GSH consumer naphthazarin, Fe 3+ , followed modification PEG2000, are strategically designed fabricated for ultrasound‐boosted cells through triple regulatory pathways. The carrier‐free FNCP NFs can rapidly dissociate under microenvironment response with assistance ultrasound, releasing 2+ Ce6, naphthazarin. Ce6 capable producing singlet oxygen ( 1 ) hydroxyl radicals · OH) ultrasound‐activated sonodynamic therapy Fenton reaction‐mediated chemodynamic (CDT), respectively, which not only induce apoptotic cell death but also lead to effective accumulation lipid peroxidation (LPO), resulting ferroptosis. Meanwhile, released naphthazarin self‐cycling valence alternations /Fe promote significant decrease intracellular contents, further inducing inactivation peroxidase 4 (GPX4) up‐regulation LPO levels, eventually realizing synergistically enhanced This facile feasible design versatile offers a new strategy effectively improving efficiency multimodal cancer therapies.

Language: Английский

Citations

14
Metal‐Phenolic Nanocloaks on Cancer Cells Potentiate STING Pathway Activation for Synergistic Cancer Immunotherapy DOI

Xianglian He,

Guidong Gong, Mei Chen

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(12)

Published: Feb. 2, 2024

Abstract Due to the presence of natural neoantigens, autologous tumor cells hold great promise as personalized therapeutic vaccines. Yet cell vaccines require multi‐step production that frequently leads loss immunoreactive antigens, causing insufficient immune activation and significantly hampering their clinical applications. Herein, we introduce a novel whole‐cell cancer vaccine by cloaking with lipopolysaccharide‐decorated manganese(II)‐phenolic networks (MnTA nanocloaks) evoke tumor‐specific response for highly efficacious synergistic immunotherapy. The polyphenols coordinate Mn 2+ immediately adhere surface individual cells, thereby forming nanocloak encapsulating neoantigens. Subsequent decoration lipopolysaccharide induces internalization dendritic where ions are released in cytosol, further facilitating stimulator interferon genes (STING) pathway. Highly effective suppression was observed combining nanocloaked treatment anti‐programmed death ligand 1 (anti‐PD‐L1) antibodies‐mediated checkpoint blockade therapy. Our work demonstrates universal yet simple strategy engineer cell‐based nanobiohybrid system enhanced

Language: Английский

Citations

10
Manganese-based nanomaterials in diagnostics and chemodynamic therapy of cancers: new development DOI Creative Commons
Meiyan Wu, Yuan Liao,

Di Guo

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(21), P. 14722 - 14741

Published: Jan. 1, 2024

Manganese-based nanomaterials have seen rapid development in chemodynamic therapy and T 1 -enhanced MRI over the past five years, holding promising prospects various combined applications.

Language: Английский

Citations

10