Angewandte Chemie,
Год журнала:
2024,
Номер
136(17)
Опубликована: Фев. 23, 2024
Abstract
We
have
accomplished
the
first
and
asymmetric
total
synthesis
of
principinol
B,
a
grayanoid
possessing
an
oxabicyclo[3.2.1]
architecture.
A
functionalized
5/7/6/5
tetracyclic
intermediate
was
assembled
in
convergent
manner
by
diastereoselective
intermolecular
aldol
reaction
subsequent
carbonyl–olefin
metathesis
two
enantiomerically
enriched
fragments.
The
architecture
containing
6,10‐ether
bridge
constructed
Williamson
ether
synthesis.
Organic Letters,
Год журнала:
2024,
Номер
26(26), С. 5409 - 5414
Опубликована: Июнь 24, 2024
Herein,
we
describe
a
novel
approach
to
the
synthesis
of
benzocycloheptene
derivatives
via
base-promoted
(5
+
2)
annulation
between
2-(alkynylaryl)acetonitriles
and
arylalkynes.
In
this
chemistry,
are
employed
as
new
C5
synthon
construct
various
benzocycloheptene(s)
by
building
two
C-C
bonds
in
one
single
step.
This
method
features
excellent
regioselectivity,
use
readily
available
starting
materials,
good
functional
group
tolerance.
The
practicality
strategy
was
further
demonstrated
gram-scale
synthesis,
late-stage
functionalizations,
post-modification
natural
products
such
probenecid
tetrahydrofurfuryl
alcohol.
ACS Catalysis,
Год журнала:
2024,
Номер
14(21), С. 15997 - 16002
Опубликована: Окт. 16, 2024
A
photoexcited
palladium-catalyzed
synthesis
of
chiral
allenes
from
alkynes
via
a
sequence
isomerization
and
deracemization
is
disclosed.
This
method
offers
an
efficient
cost-effective
approach
to
produce
wide
range
with
good
enantioselectivities
yields
(up
98%
yield
99%
ee).
The
use
readily
available
stable
as
starting
materials
simplifies
experimental
procedures
broadens
the
scope
allene
synthesis.
DBU
plays
crucial
dual
role
in
this
reaction
effectively
facilitate
enhance
under
visible
light
excitation,
both
which
are
vital
for
success
process.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(17)
Опубликована: Фев. 23, 2024
Abstract
We
have
accomplished
the
first
and
asymmetric
total
synthesis
of
principinol
B,
a
grayanoid
possessing
an
oxabicyclo[3.2.1]
architecture.
A
functionalized
5/7/6/5
tetracyclic
intermediate
was
assembled
in
convergent
manner
by
diastereoselective
intermolecular
aldol
reaction
subsequent
carbonyl–olefin
metathesis
two
enantiomerically
enriched
fragments.
The
architecture
containing
6,10‐ether
bridge
constructed
Williamson
ether
synthesis.
