Enantioselective Remote Alkylation Enabled by Metallaphotoredox Catalysis via Selective C–C Bond Cleavage

ACS Catalysis, Год журнала: 2025, Номер 15(3), С. 2212 - 2221

Опубликована: Янв. 23, 2025

Despite recent advances in enantioselective radical coupling with strained cyclic rings, asymmetric reactions triggered by unstrained motifs remain rare. Herein, we report a mild and general strategy for activating diverse set of readily available alcohols the remote site-specific allylic alkylation ketones through combination photoredox-mediated proton-coupled electron transfer chiral chromium catalysis. This newly developed dual catalytic system exhibits extensive applicability, operates under conditions, offers straightforward operation, demonstrates tolerance to functional groups. The open-shell has also been applied late-stage modification complex drug natural product derivatives high levels enantioselectivity.

Язык: Английский

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Nickel-catalyzed carbonylative four-component 1,4-dicarbofunctionalization of 1,3-enynes

Science China Chemistry, Год журнала: 2024, Номер 67(6), С. 2029 - 2038

Опубликована: Апрель 24, 2024

Язык: Английский

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Molybdenum disulfide promoted co-catalyzed alkoxycarbonylation

Journal of Catalysis, Год журнала: 2024, Номер 430, С. 115349 - 115349

Опубликована: Фев. 1, 2024

Язык: Английский

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Copper‐Catalyzed Aromatization‐Driven Ring‐Opening Amination and Oxygenation of Spiro Dihydroquinazolinones

Chemistry - A European Journal, Год журнала: 2024, Номер 30(58)

Опубликована: Авг. 8, 2024

Abstract Mild and inexpensive copper‐catalyzed aromatization‐driven ring‐opening amination oxygenation of spiro dihydroquinazolinones are presented, respectively. These protocols provide facile atom‐economical access to the aminated carbonyl‐containing quinazolin‐4(3 H )‐ones in good yields with functional group compatibility, which difficult obtain by conventional methods. Remarkably, a telescoped procedure involving condensation ring‐opening/functionalization for simple cycloalkanone was found be accessible. Mechanistic studies suggest radical pathway this transformation.

Язык: Английский

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HDAC inhibitor SAHA triggers the production of previously undescribed sesquiterpenes and undergoes biotransformation by the fungus Robillarda sessilis from Verbena officinalis L.

Phytochemistry, Год журнала: 2025, Номер unknown, С. 114411 - 114411

Опубликована: Янв. 1, 2025

Язык: Английский

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Transition Metal‐Catalyzed Aminocarbonylation Reactions

The Chemical Record, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

Abstract Transition‐metal‐catalyzed aminocarbonylation reactions using low‐cost and accessible CO gas as a C1 building block amine nucleophile have been widely used to prepare amides, which are broadly exist in bioactive drugs, natural products, polymers. This type of reaction has also applied construct various biologically active heterocycles. In this review, we highlight involving under transition metal catalysis systems (palladium, rhodium, ruthenium, iridium, iron, copper, cobalt) over the past decade.

Язык: Английский

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Iron-Catalyzed Three-Component Reactions of Cyclopropanols with Alkenes and N-Heteroarenes via Ring-Opening and C–H Functionalization

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 13, 2025

An iron-catalyzed ring-opening multicomponent reaction of cyclopropyl alcohols with alkenes and N-heteroarenes involving aryl C(sp2)-H functionalization was developed. This protocol facilitates the regioselective introduction both β-carbonyl moiety an N-heteroarene group across C═C bond alkene, thus allowing a straightforward, efficient, facile access to 5-heteroarene ketones. In this process, strategy relies on alkyl radical formation from alcohols, addition bonds, heteroaryl cascades. general approach displays excellent selectivity control broad functional-group tolerance.

Язык: Английский

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Regioselective C-C bond cleavage/aminocarbonylation cascade under copper catalysis

Science China Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Авг. 28, 2024

Язык: Английский

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