Regioselective C-C bond cleavage/aminocarbonylation cascade under copper catalysis DOI

Qi-Chao Shan,

Zhao Yan,

Yong Wu

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Language: Английский

Enantioselective Remote Alkylation Enabled by Metallaphotoredox Catalysis via Selective C–C Bond Cleavage DOI
Ao Yu,

Ning Wang,

Siyuan Tang

et al.

ACS Catalysis, Journal Year: 2025, Volume and Issue: 15(3), P. 2212 - 2221

Published: Jan. 23, 2025

Despite recent advances in enantioselective radical coupling with strained cyclic rings, asymmetric reactions triggered by unstrained motifs remain rare. Herein, we report a mild and general strategy for activating diverse set of readily available alcohols the remote site-specific allylic alkylation ketones through combination photoredox-mediated proton-coupled electron transfer chiral chromium catalysis. This newly developed dual catalytic system exhibits extensive applicability, operates under conditions, offers straightforward operation, demonstrates tolerance to functional groups. The open-shell has also been applied late-stage modification complex drug natural product derivatives high levels enantioselectivity.

Language: Английский

Citations

1
HDAC inhibitor SAHA triggers the production of previously undescribed sesquiterpenes and undergoes biotransformation by the fungus Robillarda sessilis from Verbena officinalis L. DOI

Liangxiu Liao,

Junguo Huang,

Zhu Tao

et al.

Phytochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 114411 - 114411

Published: Jan. 1, 2025

Language: Английский

Citations

0
Transition Metal‐Catalyzed Aminocarbonylation Reactions DOI
Fatemeh Doraghi, Mohammad Hossein Morshedsolouk,

Niki Raisi

et al.

The Chemical Record, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Abstract Transition‐metal‐catalyzed aminocarbonylation reactions using low‐cost and accessible CO gas as a C1 building block amine nucleophile have been widely used to prepare amides, which are broadly exist in bioactive drugs, natural products, polymers. This type of reaction has also applied construct various biologically active heterocycles. In this review, we highlight involving under transition metal catalysis systems (palladium, rhodium, ruthenium, iridium, iron, copper, cobalt) over the past decade.

Language: Английский

Citations

0
Iron-Catalyzed Three-Component Reactions of Cyclopropanols with Alkenes and N-Heteroarenes via Ring-Opening and C–H Functionalization DOI
Jie Yang, Shuang Wu, Ying Chu

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

An iron-catalyzed ring-opening multicomponent reaction of cyclopropyl alcohols with alkenes and N-heteroarenes involving aryl C(sp2)-H functionalization was developed. This protocol facilitates the regioselective introduction both β-carbonyl moiety an N-heteroarene group across C═C bond alkene, thus allowing a straightforward, efficient, facile access to 5-heteroarene ketones. In this process, strategy relies on alkyl radical formation from alcohols, addition bonds, heteroaryl cascades. general approach displays excellent selectivity control broad functional-group tolerance.

Language: Английский

Citations

0
Molybdenum disulfide promoted co-catalyzed alkoxycarbonylation DOI
Zhaohui Zheng, Hao Zhou, Li Deng

et al.

Journal of Catalysis, Journal Year: 2024, Volume and Issue: 430, P. 115349 - 115349

Published: Feb. 1, 2024

Language: Английский

Citations

3
Nickel-catalyzed carbonylative four-component 1,4-dicarbofunctionalization of 1,3-enynes DOI

Zhao Yan,

Qi-Chao Shan,

Xin Hong

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(6), P. 2029 - 2038

Published: April 24, 2024

Language: Английский

Citations

3
Copper‐Catalyzed Aromatization‐Driven Ring‐Opening Amination and Oxygenation of Spiro Dihydroquinazolinones DOI Open Access
Wenke Li,

Hong-Jie Miao,

Jinhua Zhang

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(58)

Published: Aug. 8, 2024

Abstract Mild and inexpensive copper‐catalyzed aromatization‐driven ring‐opening amination oxygenation of spiro dihydroquinazolinones are presented, respectively. These protocols provide facile atom‐economical access to the aminated carbonyl‐containing quinazolin‐4(3 H )‐ones in good yields with functional group compatibility, which difficult obtain by conventional methods. Remarkably, a telescoped procedure involving condensation ring‐opening/functionalization for simple cycloalkanone was found be accessible. Mechanistic studies suggest radical pathway this transformation.

Language: Английский

Citations

2
Regioselective C-C bond cleavage/aminocarbonylation cascade under copper catalysis DOI

Qi-Chao Shan,

Zhao Yan,

Yong Wu

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Language: Английский

Citations

1