Aptasensors and Advancement in Molecular Recognition Technology

Advanced Materials Technologies, Год журнала: 2024, Номер unknown

Опубликована: Июль 2, 2024

Abstract Synthetic oligonucleic acids known as aptamers exhibit remarkable selectivity and affinity for target recognition binding. Selected via an iterative process “selective evolution of ligands by exponential enrichment” (SELEX), fold into defined 3D conformations to interact with their targets. The incorporation elements has driven notable progress in biosensors, giving rise the development aptasensors. Here, aptamer discovery various types aptasensors are summarized. fundamental design principles elaborated along superiority compared antibodies. modes employed aptasensors, such structure‐switching design, hybridization chain reaction amplification, enzyme‐assisted recycling, split examined. Further light is shed on diverse landscape adaptability different analytes well potential propel advancements modern biosensor technology. As a nucleic acids‐based platform, poise become next generation sensitive cost‐effective technology shape future molecular biosensing.

Язык: Английский

---

Advances in magnetic affinity-based isolation/detection of exosomes for robust diagnostics

Microchimica Acta, Год журнала: 2025, Номер 192(4)

Опубликована: Март 5, 2025

The review article provides a short introduction to exosomes with the focus use as disease markers itself (i.e. their concentration or presence of some specific receptors) source biomarkers such proteins and metabolites. In detail, we are discussing various methods exosome isolation main paper is on affinity capture exosomes, since them can be applied sub-populations produced by organs. comprehensive overview magnetic (bio)affinity detection exosomal cargo using different ligands antibodies, DNA aptamers, peptides, glycan-based recognition, transferrin-based approaches, based recognition phospholipids other approaches including electrostatic interactions. in detail key analytical clinical parameters form an extensive table summarising outcomes published last two years (2023-2024). Finally, also conclusions sections pros cons for and/or determination content.

Язык: Английский

---

MXene–AuNCs-based electrochemical aptasensor for ultrasensitive detection of neuron-specific enolase in early lung cancer diagnosis

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112732 - 112732

Опубликована: Янв. 1, 2025

Язык: Английский

---

Advances and applications of G-quadruplex in diagnostics

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112737 - 112737

Опубликована: Янв. 1, 2025

Язык: Английский

---

Creating a Fluorescent “AND” Logic Gate Aptamer Platform for Identifying Exosomes Derived from Breast Cancer Subtypes

Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112683 - 112683

Опубликована: Янв. 1, 2025

Язык: Английский

---

H9N2 avian influenza virus diagnostics utilizing specific high-sensitivity enzymatic molecular system termed RPA-based CRISPR-Cas13a

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140474 - 140474

Опубликована: Янв. 1, 2025

Язык: Английский

---

Restriction endonuclease-mediated PAM-free CRISPR/Cas12a strategy for one-pot sensitive detection of Escherichia coli O157:H7

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160330 - 160330

Опубликована: Фев. 1, 2025

Язык: Английский

---

Hydrogel sensing platforms for monitoring contractility in in vitro cardiac models

Nanoscale, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review summarizes current methods for monitoring cardiomyocyte contractility and explores recent advances in hydrogel-based platforms cell contraction forces. Copyright 2023, Springer Nature; 2019 2022, John Wiley Sons.

Язык: Английский

---

On-demand controlled bidirectional DNAzyme path for ultra-sensitive heavy metal ion detection

Chemical Science, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

A bidirectional self-powered biosensor is constructed for the quasi-simultaneous detection of Pb

Язык: Английский

---

Dual-mode ultrasensitive detection of acute leukemia gene Pax-5a based on smart DNA programmed dendrimer

Biosensors and Bioelectronics, Год журнала: 2024, Номер 272, С. 117111 - 117111

Опубликована: Дек. 29, 2024

Язык: Английский

---