A novel AIRE-based fluorescent ratiometric probe with endoplasmic reticulum-targeting ability for detection of hypochlorite and bioimaging

Bioorganic Chemistry, Год журнала: 2022, Номер 131, С. 106319 - 106319

Опубликована: Дек. 15, 2022

Язык: Английский

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Research progress on AIE cyanostilbene-based self-assembly gels: Design, regulation and applications

Coordination Chemistry Reviews, Год журнала: 2022, Номер 471, С. 214753 - 214753

Опубликована: Авг. 9, 2022

Язык: Английский

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Recent progress on photodynamic therapy and photothermal therapy

Bulletin of the Korean Chemical Society, Год журнала: 2022, Номер 44(3), С. 236 - 255

Опубликована: Дек. 15, 2022

Abstract Noninvasive treatments for terminal cancer patients constitute a new trend in tumor treatment. Therefore, phototherapy, including photodynamic therapy (PDT) and photothermal (PTT), has attracted considerable interest. Light photosensitizer (PS) are employed both treatment methods. For PDT, the PS generates reactive oxygen species (ROS) when exposed to light, whereas PTT, heat. In this regard, systematic design of PSs become an active area phototherapy research effort solve problems associated with conventional PSs. past decade, activatable heavy‐atom‐free have significant areas. we discuss our recent contributions PDT PTT account.

Язык: Английский

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Review: Recent progress in fluorescent molecular systems for the detection of disease-related biomarkers in biofluids

Coordination Chemistry Reviews, Год журнала: 2023, Номер 494, С. 215336 - 215336

Опубликована: Июль 16, 2023

Язык: Английский

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Development of meso-Five-Membered Heterocycle BODIPY-Based AIE Fluorescent Probes for Dual-Organelle Viscosity Imaging

Analytical Chemistry, Год журнала: 2023, Номер 95(25), С. 9646 - 9653

Опубликована: Июнь 13, 2023

Fluorescent rotors with aggregation-induced emission (AIE) and organelle-targeting properties have attracted great attention for sensing subcellular viscosity changes, which could help understand the relationships of abnormal fluctuations many associated diseases. Despite numerous efforts spent, it remains rare urgent to explore dual-organelle targeting probes their structural viscosity-responsive AIE properties. Therefore, in this work, we reported four meso-five-membered heterocycle-substituted BODIPY-based fluorescent probes, explored properties, further investigated localization viscosity-sensing applications living cells. Interestingly, meso-thiazole probe 1 showed both good (in pure water) successfully target mitochondria lysosomes, imaging cellular changes by treating lipopolysaccharide nystatin, attributing free rotation potential ability group. The meso-benzothiophene 3 a saturated sulfur only cells aggregation-caused quenching effect no localization. meso-imidazole 2 phenomenon without an obvious property C═N bond, while meso-benzopyrrole 4 displayed fluorescence polar solvents. first time, structure-property among these, bond on meso-thiazole, potentially contributing corresponding served as sensitive rotor lysosomes.

Язык: Английский

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Aggregation-induced emission: An illuminator in the brain

Coordination Chemistry Reviews, Год журнала: 2023, Номер 482, С. 215070 - 215070

Опубликована: Фев. 24, 2023

The brain is the central control hub of whole body. Hence, consequences diseases can be lethal. Despite progress in fundamental and clinical research, several key obstacles remain to addressed. As an emerging science, aggregation-induced emission (AIE) has attracted great interest past few years owing overwhelming advantages AIE luminogens (AIEgens), including their wavelength, quantum yield, spatial resolution, photosensitivity, photostability, signal-to-noise ratio, biocompatibility. Herein, we provide a comprehensive summary AIEgen applications health evaluation, disease detection, diagnosis, imaging, therapeutics. review been summarized into five sections: i) Penetration AIEgen-based nanomaterials across biological barriers; ii) Detection diagnosis with AIEgen; iii) Bioimaging structure iv) Therapeutics for specific using v) Future outlooks surrounding AIEgens brain. We hope that this will promote deeper understanding use neuroscience community inspire additional research aimed at improving current situation clinic.

Язык: Английский

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Renal-Clearable Probe with Water Solubility and Photostability for Biomarker-Activatable Detection of Acute Kidney Injuries via NIR-II Fluorescence and Optoacoustic Imaging

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(14), С. 17664 - 17674

Опубликована: Апрель 3, 2023

Acute kidney injuries (AKI) have serious short-term or long-term complications with high morbidity and mortality rate, thus posing great health threats. Developing high-performance NIR-II probes for noninvasive in situ detection of AKI via fluorescent optoacoustic dual-mode imaging is significance. Yet chromophores often feature long conjugation hydrophobicity, which prevent them from being renal clearable, limiting their applications the diseases. To fully exploit advantageous features heptamethine cyanine dye, while overcoming its relatively poor photostability, to strive design a probe imaging, herein, we developed PEG3-HC-PB, water soluble, biomarker activatable has good photostability. As probe, fluorescence (900-1200 nm) quenched due existence electron-pulling phenylboronic group (responsive element), it exhibits weak absorption peak at 830 nm. Meanwhile, presence overexpressed H2O2 region case AKI, converted phenylhydroxy group, enhances emission (600-900 eventually produces conspicuous signals imaging. This enables contrast-agent-induced ischemia/reperfusion-induced mice using real-time 3D-MSOT response H2O2. Hence, this can be used as practicable tool detecting AKI; additionally, strategy could provide insight into other large-conjugation multifarious biological applications.

Язык: Английский

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Recent advances in enzyme-activated NIR fluorescent probes for biological applications

TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 168, С. 117335 - 117335

Опубликована: Сен. 27, 2023

Язык: Английский

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A multifunctional nanoaggregate‐based system for detection of rheumatoid arthritis via Optoacoustic/NIR‐II fluorescent imaging and therapy via inhibiting JAK‐STAT/NF‐κB/NLRP3 pathways

Aggregate, Год журнала: 2023, Номер 5(1)

Опубликована: Сен. 11, 2023

Abstract Rheumatoid arthritis (RA) is a debilitating autoimmune disease that causes chronic pain and serious complications, presenting significant challenge to treat. Promising approaches for treating RA involve signaling pathways modulation targeted therapy. To this end, multifunctional nanosystem, TPC‐U@HAT, has been designed therapy, featuring multitargeting, dual‐stimuli response, on‐demand drug release capabilities. TPC‐U@HAT composed of probe/prodrug TPC, JAK1 kinase inhibitor upadacitinib, the carrier HAT. TPC an aggregation‐induced emission (AIE)‐active NIR‐II chromophore TPY NF‐κB/NLRP3 caffeic acid phenethyl ester (CAPE), connected via boronic bond which serves as reactive‐oxygen‐species‐responsive linker. The carrier, HAT, created by grafting bone‐targeting alendronate hydrophobic tocopheryl succinate onto hyaluronic chains, can encapsulate upadacitinib form TPC‐U@HAT. Upon intravenous injection into mice, accumulates at inflamed lesions through both active passive targeting, overexpressed hyaluronidase H 2 O therein cleave polymer chains boronate bonds, respectively. This generates AIE‐active detection therapeutic evaluation optoacoustic imaging fluorescent concomitantly releases CAPE exert efficacious therapy inhibiting JAK‐STAT pathways.

Язык: Английский

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Oxidization enhances type I ROS generation of AIE-active zwitterionic photosensitizers for photodynamic killing of drug-resistant bacteria

Chemical Science, Год журнала: 2023, Номер 14(18), С. 4863 - 4871

Опубликована: Янв. 1, 2023

Type I photosensitizers (PSs) with an aggregation-induced emission (AIE) feature have received sustained attention for their excellent theranostic performance in the treatment of clinical diseases. However, development AIE-active type PSs strong reactive oxygen species (ROS) production capacity remains a challenge due to lack in-depth theoretical studies on aggregate behavior and rational design strategies. Herein, we proposed facile oxidization strategy enhance ROS generation efficiency PSs. Two AIE luminogens, MPD its oxidized product MPD-O were synthesized. Compared MPD, zwitterionic showed higher efficiency. The introduction electron-withdrawing atoms results formation intermolecular hydrogen bonds molecular stacking MPD-O, which endowed more tightly packed arrangement state. Theoretical calculations demonstrated that accessible intersystem crossing (ISC) channels larger spin-orbit coupling (SOC) constants provide further explanation superior evidenced effectiveness enhancing ability by strategy. Moreover, DAPD-O, cationic derivative was synthesized improve antibacterial activity showing photodynamic against methicillin-resistant S. aureus both vitro vivo. This work elucidates mechanism offers new guideline exploitation

Язык: Английский

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