Angewandte Chemie,
Год журнала:
2024,
Номер
137(1)
Опубликована: Сен. 21, 2024
Abstract
Phototheranostics
is
growing
into
a
sparking
frontier
in
disease
treatment.
Developing
single
molecular
species
synchronously
featured
by
powerful
absorption
capacity,
superior
second
near‐infrared
(NIR‐II)
fluorescence
and
prominent
photothermal
conversion
ability
highly
desirable
for
phototheranostics,
yet
remains
formidably
challenging.
In
this
work,
we
propose
design
philosophy
that
the
integration
of
noncovalent
conformational
locks
(NoCLs)
with
aggregation‐induced
emission
(AIE)
formulation
able
to
boost
multiple
photophysical
properties
efficient
phototheranostics.
The
introduction
NoCLs
skeleton
conformation‐locking
feature
center
architecture
indeed
elevates
structural
planarity
rigidity,
which
simultaneously
promotes
capacity
bathochromic‐shifts
wavelength
centered
NIR‐II
region.
Meanwhile,
AIE
tendency
mainly
originated
from
flexibly
propeller‐like
geometry
at
ends
eventually
endows
molecule
satisfactory
intensity
aggregates.
Consequently,
utilizing
optimized
molecule,
unprecedented
performance
on
fluorescence‐photoacoustic‐photothermal
trimodal
imaging‐guided
photothermal‐chemo
synergistic
therapy
demonstrated
precise
tumor
diagnosis
complete
ablation.
Materials Today Chemistry,
Год журнала:
2024,
Номер
39, С. 102178 - 102178
Опубликована: Июль 1, 2024
Inflammatory
arthritis
is
a
growing
worldwide
concern,
afflicting
millions
of
individuals
and
leading
to
depreciating
quality
life,
significant
morbidity,
subsequent
healthcare
burden.
Conventional
therapies
for
inflammatory
often
hold
limitations,
including
systemic
cross-reactivities,
side
effects,
inadequate
management
inflammation.
Therefore,
"Smart"
stimuli-responsive
biomaterials
are
materialized
as
promising
theranostic
approaches
management.
These
designed
specific
external
internal
stimulation,
enabling
the
sustained
release
bioactive
therapeutic
agents
during
local
or
administration.
Stimuli-responsive
allow
precise
spatiotemporal
control
over
drug
release,
minimizing
exposure,
reducing
off-target
real-time
monitoring
pathological
conditions,
driving
potential
breakthrough
in
managing
arthritis.
Owing
this
prominence,
review
article
expounds
on
emerging
prospects
targeting
molecular
signatures
associated
with
intricately
elicit
minimal
no
contradictory
effects.
In
addition,
application
these
disease
progression
multi-stimuli-responsive
comprehended
show
progress
diagnosis
treatment.
This
"single-platted"
comprehensive
acquaintance
clinical-based
outcomes
navigates
microenvironment,
proposing
an
optimistic
avenue
personalized
effective
minimized
ACS Nano,
Год журнала:
2025,
Номер
19(1), С. 281 - 306
Опубликована: Янв. 2, 2025
A
revolutionary
transformation
in
biomedical
imaging
is
unfolding
with
the
advent
of
aggregation-induced
emission
luminogens
(AIEgens).
These
cutting-edge
molecules
not
only
overcome
limitations
traditional
fluorescent
probes
but
also
improve
boundaries
high-contrast
imaging.
Unlike
conventional
fluorophores
suffering
from
aggregation-caused
quenching,
AIEgens
exhibit
enhanced
luminescence
when
aggregated,
enabling
superior
performance.
This
review
delves
into
molecular
mechanisms
(AIE),
demonstrating
how
strategic
design
unlocks
exceptional
and
contrast,
which
crucial
for
distinguishing
healthy
diseased
tissues.
highlights
key
applications
AIEgens,
such
as
time-resolved
imaging,
second
near-infrared
window
(NIR-II),
advancement
sensitivity
to
physical
biochemical
cue-responsive
The
development
AIE
technology
promises
transform
healthcare
early
disease
detection
targeted
therapies,
potentially
reshaping
personalized
medicine.
paradigm
shift
biophotonics
offers
efficient
tools
decode
complexities
biological
systems
at
level,
bringing
us
closer
a
future
where
invisible
becomes
visible
incurable
treatable.
Accounts of Materials Research,
Год журнала:
2024,
Номер
5(1), С. 64 - 75
Опубликована: Янв. 3, 2024
ConspectusFluorescent
dyes
have
revolutionized
the
way
we
study
life
science
and
conduct
medical
diagnostics.
Compared
with
visible
wavelengths,
near-infrared
(NIR)
fluorescence
has
gained
significant
attention
due
to
its
unique
properties,
such
as
deep
tissue
penetration,
reduced
autofluorescence,
improved
signal-to-noise
ratios,
making
it
highly
desirable
for
a
wide
range
of
in
vivo
applications
including
noninvasive
sensing,
cancer
research,
drug
delivery.In
absorption
light
by
fluorophore
subsequent
transition
an
excited
state
are
critical
steps.
Once
state,
molecule
may
undergo
various
relaxation
processes
internal
conversion,
vibrational
relaxation,
radiative/nonradiative
decay.
These
directly
impact
fluorophore's
emission
wavelength,
brightness,
photostability,
other
properties.
Therefore,
rational
modulation
molecular
states
is
vital
achieving
effective
sensing.
However,
NIR
fluorophores
small
S0–S1
energy
gap,
governed
gap
law,
exhibit
much
faster
nonradiative
deactivation
pathway
compared
region.
This
fast
process
makes
them
more
susceptible
interference
from
aggregation
behavior,
environmental
factors,
so
on.
Thus,
there
often
trade-off
effect
between
tunable
red-shift
wavelength
performance
light-up
imaging
quantitative
Overcoming
these
challenges
requires
careful
engineering
structures
achieve
desired
balance
extending
bioimaging.In
this
Account,
present
our
recent
progress
manipulating
design
fluorescent
probes.
Specifically,
focus
on
novel
building
blocks,
exploring
photophysical
mechanisms,
regulating
assembly
behavior
(to
inhibit
or
amplify
intramolecular
motion
aggregates),
aiming
resolve
long-standing
issues
lighting-up
mapping,
First,
introduce
monochromophore-based
"reliable
ratiometric"
strategy
additional
emission,
enabling
quantification
hypoxia
biomolecules.
Second,
demonstrate
how
reverse
rotation
driving
energy,
completely
overturning
charge
transfer
(ICT)
fluorophores'
quenching
mode
into
mode.
Third,
discuss
relationship
chromophore
relaxation.
Through
inhibiting
amplifying
motion,
could
well
improve
fidelity
theranostic
outcomes.
Finally,
explore
future
perspectives
dynamic
bioimaging.
It
hoped
that
Account
provides
deepening
research
guidance
development
high-performance
probes
physiological/pharmacological
studies
clinical
applications.
Advanced Materials,
Год журнала:
2024,
Номер
36(48)
Опубликована: Окт. 6, 2024
Rheumatoid
arthritis
(RA)
represents
an
insidious
autoimmune
inflammatory
disorder
that
severely
lowers
the
life
quality
by
progressively
destructing
joint
functions
and
eventually
causing
permanent
disability,
posing
a
serious
public
health
problem.
Here,
advanced
theranostic
probe
is
introduced
integrates
activatable
second
near-infrared
(NIR-II)
fluorescence
imaging
for
precise
RA
diagnosis
with
multi-pronged
treatments.
A
novel
molecular
comprising
long-wavelength
aggregation-induced
emission
unit
manganese
carbonyl
cage
motif
synthesized,
which
enables
NIR-II
activation
concurrently
releasing
therapeutic
carbon
monoxide
(CO)
gas
in
inflamed
microenvironment.
This
self-assembles
into
biocompatible
nanoprobe,
subsequently
conjugated
anti-IL-6R
antibody
to
afford
active-targeting
ability
of
RA.
The
nanoprobe
exhibits
significant
turn-on
signal
at
lesion,
enabling
highly
sensitive
real-time
monitoring.
combination
ROS
scavenging,
on-demand
CO
release,
IL-6
signaling
blockade
results
potent
effect
synergistic
immunomodulation
impact,
significantly
alleviating
symptoms
preventing
destruction.
research
introduces
paradigm
development
high-performance,
strategies
facilitate
detection
enhanced
treatment
RA-related
diseases.
The
development
of
a
photosensitizer
(PS)
that
induces
pyroptosis
could
be
star
for
photodynamic
therapy
(PDT),
particularly
with
type-I
PSs
produce
reactive
oxygen
species
(ROS)
in
hypoxic
tumor
microenvironment.
Since
is
recently
characterized
cell
death
pathway,
it
holds
promise
advancing
PDT
oncology,
playing
critical
role.
Herein,
we
develop
PS
named
Th-M
aggregation-induced
emission
(AIE)
characteristics
against
tongue
squamous
carcinoma
(TSCC).
stands
out
its
exceptional
mitochondrial-targeting
ability,
which
triggers
mitochondrial
dysfunction
and
leads
to
Caspase-3
Gasdermin
E
(GSDME)
cleavage
under
white
light
irradiation,
inducing
TSCC
cells.
Our
studies
verify
the
effectiveness
destroying
cancer
cells
vitro
suppressing
growth
vivo
while
also
demonstrating
favorable
biosafety
profile.
This
work
pioneers
application
as
mitochondria-targeted,
leverages
mechanism
pyroptosis,
offering
potent
approach
treatment
TSSC
promising
implications
future
cancers.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(26)
Опубликована: Апрель 19, 2024
Abstract
Fluorescence
sensing
is
crucial
to
studying
biological
processes
and
diagnosing
diseases,
especially
in
the
second
near‐infrared
(NIR‐II)
window
with
reduced
background
signals.
However,
it's
still
a
great
challenge
construct
“off‐on”
sensors
when
wavelength
extends
into
NIR‐II
region
obtain
higher
imaging
contrast,
mainly
due
difficult
synthesis
of
spectral
overlapped
quencher.
Here,
we
present
new
fluorescence
quenching
strategy,
which
utilizes
steric
hindrance
quencher
(SHQ)
tune
molecular
packing
state
fluorophores
suppress
emission
signal.
Density
functional
theory
(DFT)
calculations
further
reveal
that
large
SHQs
can
competitively
pack
prevent
their
self‐aggregation.
Based
on
this
mechanism,
novel
activatable
method
achieved
via
bio‐analyte
responsive
invalidation
SHQ,
namely
Steric
Hindrance
Invalidation
geNerated
Emission
(SHINE)
strategy.
As
proof
concept,
ClO
−
‐sensitive
SHQ
lead
bright
signal
release
epileptic
mouse
hippocampus
under
skull
high
photon
scattering
brain
tissue,
providing
real‐time
visualization
generation
process
living
mice.
Chemical Science,
Год журнала:
2024,
Номер
15(16), С. 6028 - 6035
Опубликована: Янв. 1, 2024
Drug
resistance
is
a
major
challenge
for
cancer
treatment,
and
its
identification
crucial
medical
research.
However,
since
drug
multi-faceted
phenomenon,
it
important
to
simultaneously
evaluate
multiple
target
fluctuations.
Recently
developed
fluorescence-based
probes
that
can
respond
targets
offer
many
advantages
real-time
in
situ
monitoring
of
cellular
metabolism,
including
ease
operation,
rapid
reporting,
their
non-invasive
nature.
As
such
we
dual-response
platform
(Vis-H2S)
with
integrated
ICT-TICT
image
H2S
viscosity
mitochondria,
which
could
track
fluctuations
cysteine
desulfurase
(NFS1
protein
inducer)
autophagy
during
chemotherapy-induced
multidrug
resistance.
This
monitor
endogenous
metabolites
the
synergistic
relationship
between
NFS1
induced
by
chemotherapy.
The
results
indicated
chemotherapeutic
drugs
up-regulate
levels
autophagy.
It
was
also
found
linked
autophagy,
eventually
led
such,
this
serve
as
an
effective
tool
in-depth
exploration
mechanisms.
Abstract
Organic
agents
possessing
NIR‐II
and
photoacoustic
duplex
imaging
capabilities,
coupled
with
high‐efficiency
photothermal
conversion,
offer
significant
potential
for
noninvasive
precise
phototheranostics
of
glioblastoma,
which
is
further
augmented
when
these
can
concurrently
exhibit
tumor
targeting
blood–brain
barrier
(BBB)
permeability.
This
study
reports
a
series
finely
tunable
molecular
luminophores
based
on
the
aza‐BODIPY
scaffold,
featuring
unique
twisted
rotatable
structures.
They
are
constructed
to
folate‐decorated
polymeric
nanoparticles,
exhibiting
remarkable
NIR‐II/photoacoustic
performance
superior
conversion
efficiency
(49.7%).
Folate
modification
enables
BBB
permeability
through
receptor‐mediated
transcytosis,
allowing
efficient
phototherapy
in
4T1‐/glioblastoma‐bearing
mice
after
single
intravenous
injection
irradiation.
presents
rational
engineering
approach
versatile
structural
scaffold
designing
emitters
tailored
photophysical
properties
desirable
phototherapeutic
efficacy,
thereby
offering
novel
perspectives
development
advanced
depth
probes
brain
therapeutics.
