Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Abstract
Photodynamic
therapy
(PDT)
is
a
powerful
strategy
for
tumor
with
noninvasiveness
and
desirable
efficacy.
However,
the
phototoxicity
of
photosensitizer
after
post‐PDT
major
obstacle
limiting
clinic
applications.
Herein,
nitric
oxide
(NO)‐activatable
reported
turn‐on
PDT
behavior
endoplasmic
reticulum
(ER)
targeting
ability
precise
therapy.
Four
o
‐thiophenediamine
derivatives
reaction‐tunable
donor/acceptor
push‐pull
electronic
effect
are
established,
systematic
structure
property
relationship
observation
reveals
following
features:
1)
reactivity
against
NO
can
be
improved
by
enhancing
electron
density
further
facilitated
upon
photo‐irradiation.
2)
enables
intramolecular
charge
transfer
process
evoking
photosensitizing
effect.
3)
only
derivative
ER
enrichment
exhibited
cancer
cell
ablation
compared
to
photosensitizers
localized
in
lysosome
lipid
droplet.
Thus,
efficient
inhibition
cells
both
vitro
vivo
realized
based
on
photo‐controlled
strategy.
This
work
provides
more
insights
into
developing
promising
activatable
advanced
microenvironment
trigger.
Theranostics,
Год журнала:
2023,
Номер
13(15), С. 5386 - 5417
Опубликована: Янв. 1, 2023
Stimuli-activatable
strategies
prevail
in
the
design
of
nanomedicine
for
cancer
theranostics.Upon
exposure
to
endogenous/exogenous
stimuli,
stimuli-activatable
could
be
self-assembled,
disassembled,
or
functionally
activated
improve
its
biosafety
and
diagnostic/therapeutic
potency.A
myriad
tumor-specific
features,
including
a
low
pH,
high
redox
level,
overexpressed
enzymes,
along
with
exogenous
physical
stimulation
sources
(light,
ultrasound,
magnet,
radiation)
have
been
considered
nano-medicinal
products.Recently,
novel
stimuli
explored
elegant
designs
emerged
nanomedicine.In
addition,
multi-functional
theranostic
has
employed
imaging-guided
image-assisted
antitumor
therapy.In
this
review,
we
rationalize
development
clinical
pressing
needs.Stimuli-activatable
self-assembly,
disassembly
functional
activation
approaches
developing
realize
better
efficacy
are
elaborated
state-of-the-art
advances
their
structural
detailed.A
reflection,
status,
future
perspectives
provided.
Advanced Materials,
Год журнала:
2023,
Номер
35(51)
Опубликована: Май 5, 2023
Abstract
Recently,
2D
transition
metal
carbide,
nitride,
and
carbonitrides
(MXenes)
materials
stand
out
in
the
field
of
tumor
therapy,
particularly
construction
functional
platforms
for
optimal
antitumor
therapy
due
to
their
high
specific
surface
area,
tunable
performance,
strong
absorption
near‐infrared
light
as
well
preferable
plasmon
resonance
effect.
In
this
review,
progress
MXene‐mediated
is
summarized
after
appropriate
modifications
or
integration
procedures.
The
enhanced
treatments
directly
performed
by
MXenes,
significant
improving
effect
MXenes
on
different
therapies,
imaging‐guided
strategies
are
discussed
detail.
Moreover,
existing
challenges
future
development
directions
presented.
Abstract
Ferroptosis
is
a
new
form
of
regulated
cell
death
featuring
iron‐dependent
lipid
peroxides
accumulation
to
kill
tumor
cells.
A
growing
body
evidence
has
shown
the
potential
ferroptosis‐based
cancer
therapy
in
eradicating
refractory
malignancies
that
are
resistant
apoptosis‐based
conventional
therapies.
In
recent
years,
studies
have
reported
number
ferroptosis
inducers
can
increase
vulnerability
cells
by
regulating
ferroptosis‐related
signaling
pathways.
Encouraged
rapid
development
ferroptosis‐driven
therapies,
interdisciplinary
fields
combine
ferroptosis,
pharmaceutical
chemistry,
and
nanotechnology
focused.
First,
prerequisites
metabolic
pathways
for
briefly
introduced.
Then,
detail
emerging
designed
boost
ferroptosis‐induced
therapy,
including
metal
complexes,
metal‐based
nanoparticles,
metal‐free
nanoparticles
summarized.
Subsequently,
application
synergistic
strategies
with
apoptosis
other
emphasis
on
use
both
cuproptosis
induce
redox
dysregulation
intracellular
bimetallic
copper/iron
metabolism
disorders
during
treatment
discussed.
Finally,
challenges
associated
clinical
translation
future
directions
potentiating
therapies
highlighted.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
Abstract
Tumor
microenvironment
(TME)‐triggered
phototheranostic
platform
offers
a
feasible
strategy
to
improve
cancer
diagnosis
accuracy
and
minimize
treatment
side
effects.
Developing
stable
biocompatible
molecular
for
TME‐activated
second
near‐infrared
(NIR‐II)
fluorescence
imaging‐guided
multimodal
cascade
therapy
is
promising
creating
desirable
anticancer
agents.
Herein,
new
NIR‐II
activatable
(IR‐FEP‐RGD‐S‐S‐S‐Fc)
presented
actively
targeted
tumor
imaging
hydrogen
sulfide
(H
2
S)
gas‐enhanced
chemodynamic‐hypothermal
photothermal
combined
(CDT/HPTT).
It
revealed
the
first
time
that
coupling
distance
between
IR‐FE
ferrocene
proportional
photoinduced
electron
transfer
(PET),
aqueous
environment
favorable
PET
generation.
The
part
of
Cyclic‐RGDfK
(cRGDfk)
peptides
can
target
benefit
endocytosis
nanoparticles.
high‐concentration
glutathione
(GSH)
in
TME
will
separate
molecule
by
GSH‐sensitive
trisulfide
bond,
realizing
light‐up
trimodal
synergistic
CDT/HPTT/gas
(GT).
In
addition,
accumulation
hydroxyl
radicals
(•OH)
down‐regulation
peroxidase
4
(GPX4)
produce
excessive
harmful
lipid
hydroperoxides,
ultimately
leading
ferroptosis.
Abstract
Herein,
a
dual‐sensitizer
prodrug,
named
pro‐THPC,
has
been
designed
to
function
as
both
photosensitizer
and
sonosensitizer
prodrug
for
precise
antitumor
combination
therapy
with
minimized
skin
phototoxicity.
Pro‐THPC
could
be
activated
by
glutathione
(GSH)
release
the
dual‐sensitizer,
THPC,
which
simultaneously
switches
on
fluorescence
emission
combined
capabilities
of
photodynamic
(PDT)
sonodynamic
(SDT).
is
further
formulated
into
nanoparticles
(NPs)
water
dispersity
enable
in
vivo
applications.
In
imaging
shows
that
pro‐THPC
NPs
group
exhibits
significantly
higher
tumor‐to‐normal
tissue
ratio
(
T
/
N
)
=
5.2
±
0.55)
compared
“always
on”
THPC
2.9
0.47)
co‐administrated
GSH
synthesis
inhibitor
(buthionine
sulfoximine,
BSO)
3.2
0.63).
addition,
generation
dual‐sensitizer's
reactive
oxygen
species
(ROS)
effectively
confined
within
tumor
tissues
due
relatively
strong
correlation
between
ROS
emission.
studies
demonstrate
remarkable
efficacy
eradicate
tumors
through
PDT
SDT
while
reducing
