Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(29)
Опубликована: Март 20, 2024
Abstract
Chronic
diabetic
wounds
pose
significant
challenges
due
to
uncontrolled
bacterial
infections,
prolonged
inflammation,
and
impaired
angiogenesis.
The
rapid
advancement
of
photo‐responsive
antibacterial
therapy
shows
promise
in
addressing
these
complex
issues,
particularly
utilizing
2D
heterojunction
materials,
which
offer
unique
properties.
Herein,
an
situ
sprayed
Bi/BiOCl
0D/2D
composite
fibrin
gel
with
the
characteristics
formation
effective
near‐infrared
activation
is
designed
for
treatment
non‐healing
diabetes‐infected
wounds.
can
provide
protective
shielding
skin
tissues
promote
endothelial
cell
proliferation,
vascularization,
heterojunction,
its
localized
surface
plasmon
resonance
(LSPR),
overcome
wide
bandgap
limitation
BiOCl,
enhancing
generation
local
heat
reactive
oxygen
species
under
irradiation.
This
facilitates
elimination
reduced
supporting
accelerated
healing
study
underscores
potential
LSPR‐enhanced
heterojunctions
as
advanced
wound
therapies
chronic
ACS Omega,
Год журнала:
2023,
Номер
8(24), С. 21391 - 21409
Опубликована: Июнь 7, 2023
Biofilm-associated
infections
have
emerged
as
a
significant
public
health
challenge
due
to
their
persistent
nature
and
increased
resistance
conventional
treatment
methods.
The
indiscriminate
usage
of
antibiotics
has
made
us
susceptible
range
multidrug-resistant
pathogens.
These
pathogens
show
reduced
susceptibility
intracellular
survival.
However,
current
methods
for
treating
biofilms,
such
smart
materials
targeted
drug
delivery
systems,
not
been
found
effective
in
preventing
biofilm
formation.
To
address
this
challenge,
nanotechnology
provided
innovative
solutions
formation
by
clinically
relevant
Recent
advances
nanotechnological
strategies,
including
metallic
nanoparticles,
functionalized
dendrimers,
polymeric
cyclodextrin-based
delivery,
solid
lipid
polymer
conjugates,
liposomes,
may
provide
valuable
technological
against
infectious
diseases.
Therefore,
it
is
imperative
conduct
comprehensive
review
summarize
the
recent
advancements
limitations
advanced
nanotechnologies.
present
Review
encompasses
summary
agents,
mechanisms
that
lead
formation,
impact
on
human
health.
In
nutshell,
offers
survey
managing
infections.
A
detailed
presentation
how
these
strategies
improve
control
prevent
key
objective
mechanisms,
applications,
prospects
nanotechnologies
better
understanding
Progress in Materials Science,
Год журнала:
2024,
Номер
144, С. 101292 - 101292
Опубликована: Апрель 6, 2024
The
prevalence
of
multidrug-resistant
(MDR)
bacterial
infections
has
emerged
as
a
serious
threat
to
clinical
treatment
and
global
human
health,
become
one
the
most
important
challenges
in
therapy.
Hence,
there
is
an
urgent
need
develop
safe,
effective,
new
antibacterial
strategies
based
on
multifunctional
nanomaterials
for
accurate
detection
MDR
infections.
Chemodynamic
therapy
(CDT)
emerging
therapeutic
strategy
that
uses
Fenton/Fenton-like
metal-based
nanocatalysts
convert
hydrogen
peroxide
(H2O2)
into
hydroxyl
radicals
(OH)
destroy
Despite
enormous
potential
CDT,
single
CDT
limitations
such
low
catalytic
efficacy
insufficient
production
H2O2.
In
this
regard,
can
be
combined
with
other
strategies,
photothermal
(PTT),
which
effectively
enhanced
by
PTT
heating
effect.
Thus,
rational
combination
nanoplatform
been
demonstrated
highly
efficient
achieving
better
This
review
summarizes
discusses
latest
advances
photothermal-enhanced
(PT/CDT)
infection
theranostics
well
advantages,
challenges,
future
research
directions
applications,
will
inspire
development
PT/CDT
Antibiotic-resistant
bacteria
often
cause
lethal
infections
in
both
the
surficial
and
deep
organs
of
humans.
Failure
antibiotics
resistant
leads
to
more
effective
alternative
therapies,
like
spatiotemporally
controllable
piezodynamic
therapy
(PZDT)
with
penetration.
Currently,
PZDT
demands
further
investigation
for
improved
treatment
outcomes
corresponding
therapeutic
mechanisms.
Herein,
a
nanocomposite
cloaked
is
reported
biomimetic
coating
TLR-upregulated
macrophage
membrane
targeted
against
MRSA-induced
skin
wound
infection
osteomyelitis,
representing
models,
respectively.
To
boost
efficacy,
crystal
defect
engineering
applied
by
impregnating
Fe2+
into
bismuth
oxy-iodide
nanosheets
increase
defects.
This
results
significantly
higher
piezoelectric
coefficient
than
previous
reports,
contributing
an
amplified
reactive
oxygen
species
generation
bacterial
killing.
More
importantly,
notable
effect
not
only
re-programs
macrophages
anti-inflammatory
M2
phenotype
accelerating
healing
but
also
stimulates
opening
piezo-stimulated
Ca2+
channels
boosts
differentiation
mesenchymal
stem
cells
osteoblasts
expediting
bone
tissue
repair
osteomyelitis
model.
Moreover,
Fe-doping
supplements
T2-magnetic
resonance
imaging
real-time
visualization
distribution.
theranostic
system
opens
new
avenue
future
drug-resistant
bacteria-caused
diseases.
Biomaterials Science,
Год журнала:
2023,
Номер
11(15), С. 5108 - 5128
Опубликована: Янв. 1, 2023
This
review
mainly
summarises
the
recent
progress
in
development
of
organic
photosensitizers,
including
porphyrins,
chlorophyll,
phenothiazines,
xanthenes
and
aggregation-induced
emission
for
antimicrobial
photodynamic
therapy.
