Copper(I) Complexes With Phenanthroline‐Functionalized NHC Ligands Achieve Effective Anticancer Activity via Mitochondrial and Endoplasmic Reticulum Stress DOI
Chao Chen,

Y Zheng,

Hong Rao

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 39(1)

Published: Sept. 17, 2024

ABSTRACT Copper complexes exhibit promising anticancer properties, which can be further promoted by suitable ligands. In this study, we synthesized and investigated the effects of three copper(I) with N‐heterocyclic carbene (NHC) ligands derived from phenanthroline‐functionalized imidazole salts. The synthesis these NHC‐copper(I) ( Cu1 ‐ Cu3 ) was meticulously characterized using NMR elemental analysis; their crystal structures were delineated X‐ray diffraction. Our findings illustrate unique geometric configurations complexes: features a dinuclear arrangement off‐linear geometry; Cu2 are bi‐copper core stabilized two phenanthroline‐modified Crucially, in vitro cytotoxic evaluations revealed that possess suitability activity. Among them, exhibited enhanced cytotoxicity activity, achieving half‐maximal inhibitory concentration (IC 50 4.36 ± 0.25 μM colon cancer cell line HCT‐116, markedly surpassing efficacy cisplatin. Subsequent investigations elucidated notably increases intracellular reactive oxygen species (ROS) levels induces mitochondrial membrane depolarization endoplasmic reticulum stress, leading to oxidative stress‐mediated apoptosis cells.

Language: Английский

Bioactive Layered Double Hydroxides for Synergistic Sonodynamic/Cuproptosis Anticancer Therapy with Elicitation of the Immune Response DOI
Wei Tang, Jie Wu, Li Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(15), P. 10495 - 10508

Published: April 1, 2024

Sonodynamic therapy (SDT) has promising application prospects in tumor therapy. However, SDT does not eradicate metastatic tumors. Herein, Cu-substituted ZnAl ternary layered double hydroxide nanosheets (ZCA NSs) were developed as both sonosensitizers and copper nanocarriers for synergistic SDT/cuproptosis cancer An optimized electronic structure more conducive to the sonodynamic process was obtained from ZCA NSs via Jahn–Teller effect induced by introduction of Cu2+, synthesized regulated intricate microenvironment (TME) depleting endogenous glutathione (GSH) amplify oxidative stress further enhanced performance. Furthermore, cuproptosis evoked intracellular overload Cu2+ amplified SDT, leading irreversible proteotoxicity. In vitro results showed that such synergetic triggered immunogenic cell death (ICD) promoted maturation dendritic cells (DCs). as-synthesized NS-mediated thoroughly eradicated vivo solid tumors simultaneously elicited antitumor immunity suppress lung liver metastasis. Overall, this work established a nanoplatform with satisfactory immunity.

Language: Английский

Citations

38
Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review DOI Creative Commons

Sara Abdolmaleki,

Alireza Aliabadi, Samad Khaksar

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(4)

Published: April 25, 2024

Abstract Copper is a necessary micronutrient for maintaining the well-being of human body. The biological activity organic ligands, especially their anticancer activity, often enhanced when they coordinate with copper(I) and (II) ions. its compounds are capable inducing tumor cell death through various mechanisms action, including activation apoptosis signaling pathways by reactive oxygen species (ROS), inhibition angiogenesis, induction cuproptosis, paraptosis. Some copper complexes currently being evaluated in clinical trials ability to map hypoxia cancers, locally advanced rectal cancer bulky tumors. Several studies have shown that nanoparticles can be used as effective agents chemodynamic therapy, phototherapy, hyperthermia, immunotherapy. Despite promising copper-based compounds, use subject certain limitations. Elevated concentrations may promote growth, metastasis affecting cellular processes.

Language: Английский

Citations

24
Copper(II) Complexes with 2,2′:6′,2″-Terpyridine Derivatives Displaying Dimeric Dichloro−μ–Bridged Crystal Structure: Biological Activities from 2D and 3D Tumor Spheroids to In Vivo Models DOI Creative Commons
Katarzyna Choroba, B. Machura, Karol Erfurt

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(7), P. 5813 - 5836

Published: March 22, 2024

Eight 2,2′:6′,2″-terpyridines, substituted at the 4′-position with aromatic groups featuring variations in π-conjugation, ring size, heteroatoms, and methoxy groups, were employed to enhance antiproliferative potential of [Cu2Cl2(R-terpy)2](PF6)2. Assessing cytotoxicity A2780 (ovarian carcinoma), HCT116 (colorectal HCT116DoxR carcinoma resistant doxorubicin) normal primary fibroblasts revealed that Cu(II) complexes 4-quinolinyl, 4-methoxy-1-naphthyl, 2-furanyl, 2-pyridynyl substituents showed superior therapeutic cells significantly reduced (42–129× lower). Besides their cytotoxicity, are able increase intracellular ROS interfere cell cycle progression, leading death by apoptosis autophagy. Importantly, they demonstrated antimetastatic antiangiogenic properties without vivo toxicity. In accordance nuclear accumulation, cleave pDNA interact bovine serum albumin, which is a good indication ability for internalization transport toward tumor cells.

Language: Английский

Citations

12
Biocompatible Copper-Based Nanocomposites for Combined Cancer Therapy DOI

Yibo Song,

Kok Bing Tan, Shu‐Feng Zhou

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(6), P. 3673 - 3692

Published: May 8, 2024

Copper (Cu) and Cu-based nanomaterials have received tremendous attention in recent years because of their unique physicochemical properties good biocompatibility the treatment various diseases, especially cancer. To date, researchers designed fabricated a variety integrated nanocomplexes with distinctive nanostructures applied them cancer therapy, mainly including chemotherapy, radiotherapy (RT), photothermal therapy (PTT), chemodynamic (CDT), photodynamic (PDT), cuproptosis-mediated etc. Due to limited effect single method, development composite diagnostic nanosystems that integrate PTT, CDT, PDT, other treatments is great significance offers potential for next generation anticancer nanomedicines. In view rapid field this review focuses on current state research nanomaterials, followed by discussion combined therapy. Moreover, challenges future prospects clinical translation are proposed provide some insights into design nanotherapeutic platforms.

Language: Английский

Citations

9
Current roles of metals in arming sonodynamic cancer therapy DOI

Zhuoli Chen,

Xianbo Wu, Jinzhe Liang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 521, P. 216169 - 216169

Published: Aug. 24, 2024

Language: Английский

Citations

8
Antiviral and antibacterial efficacy of nanocomposite amorphous carbon films with copper nanoparticles DOI
Shahd Bakhet, Asta Tamulevičienė, Andrius Vasiliauskas

et al.

Applied Surface Science, Journal Year: 2024, Volume and Issue: 670, P. 160642 - 160642

Published: July 4, 2024

Language: Английский

Citations

7
NIR-IIb fluorescence antiangiogenesis copper nano-reaper for enhanced synergistic cancer therapy DOI Creative Commons
Wenling Li,

Huan Xin,

Wenjuan Gao

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 19, 2024

The formation of blood vessel system under a relatively higher Cu

Language: Английский

Citations

4
Three Birds with One Stone: Copper Ions Assisted Synergistic Cuproptosis/Chemodynamic/Photothermal Therapy by a Three‐Pronged Approach DOI

Mengyao Chen,

Chang Xu, Chunhui Wang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(29)

Published: July 4, 2024

Copper is indispensable to organisms, while its homeostatic imbalance may interference normal cellular physiological processes and even induce cell death. Artificially regulating copper content provides a viable strategy activate antineoplastic effect. In light of this, ions homeostasis perturbator (CuP-CL) with cinnamaldehyde (Cin) packaging thermosensitive liposome coating reported. Following laser exposure, the doping Cu

Language: Английский

Citations

4
Structure-dependent aggregation and ROS-generation in aqueous media of new cationic copper(I) complexes based on 1,5,3,7-diazadiphosphacyclooctanes DOI
Bulat A. Faizullin, Yulia S. Spiridonova, Kirill V. Kholin

et al.

Inorganica Chimica Acta, Journal Year: 2024, Volume and Issue: unknown, P. 122382 - 122382

Published: Sept. 1, 2024

Language: Английский

Citations

4
Nanoenhanced‐Cuproptosis Results From the Synergy of Calcium Overload and GSH Depletion with the Increasing of Intracellular Ca/Mn/Cu Ions DOI Creative Commons

Shiwei Liu,

Wennan Yan,

Wenyue Zhang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract Cuproptosis is a newly discovered copper‐dependent form of cell death. Intracellular glutathione (GSH) acts as copper chelator to inhibit cuproptosis, so the reduction GSH concentration conducive enhancing cuproptosis cells. In order reduce content and interfere with mitochondrial metabolism, strategy based on calcium overload depletion enhance proposed in this study. Containing manganese (Mn) (Cu) elements, CaCO 3 nanoparticles (NPs) are modified MCF‐7 aptamer (CaCO /Mn/Cu@lip‐Apt). When entering cell, /Mn/Cu@lip‐Apt decomposed released Mn* (Mn 2+ /Mn 3+ 4+ ), Cu Ca . The high valence Mn ion can effectively consume produce which catalyzed H 2 O reactive oxygen species (ROS), while reducing concentration. production ROS promoted influx exogenous large accumulation led intracellular overload, resulting dysfunction metabolism disorders. , turn triggered cuproptosis. This showed excellent antitumor effects provided new way study disease treatment.

Language: Английский

Citations

0