Journal of Inorganic Biochemistry, Год журнала: 2024, Номер 258, С. 112639 - 112639
Опубликована: Июнь 13, 2024
Язык: Английский
Advanced Materials, Год журнала: 2024, Номер 36(35)
Опубликована: Июнь 27, 2024
Cuproptosis is a novel copper-dependent programmed cell death. The efficacy of cuproptosis highly dependent on intracellular copper accumulation and counteracted by high level glutathione (GSH) in tumor cells. Here, this work develops self-amplified nanoparticles (Cel-Cu NP) using celastrol (Cel), natural product isolated from medical plant. In Cel-Cu NP, Cel serves as versatile ionophore, exhibiting an ideal coordination capacity toward ions without compromising the induction. Notably, can simultaneously scavenge GSH content to amplify cuproptosis. Moreover, further activates immunogenic death (ICD) elicit robust immune response. Combining with checkpoint blockade, NP effectively eradicates metastatic tumors mouse lung metastasis model. This study provides efficient nanomedicine inducing for immunotherapy.
Язык: Английский
Процитировано
42
Chemical Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 16, 2025
Vanadium is a transition metal with important industrial, technological, biological, and biomedical applications widespread in the environment living beings. The different reactions that vanadium compounds (VCs) undergo presence of proteins, nucleic acids, lipids metabolites under mild physiological conditions are reviewed. In present naturally or through anthropogenic sources, latter having an environmental impact caused by dispersion VCs atmosphere aquifers. has versatile chemistry interconvertible oxidation states, variable coordination number geometry, ability to form polyoxidovanadates various nuclearity structures. If VC added water-containing it can hydrolysis, ligand-exchange, redox, other types changes, determined speciation vanadium. Importantly, solution likely differ from introduced into system varies concentration. Here, hydrolytic ligand-exchange chemical reactions, influence pH, concentration, salt, specific solutes, biomolecules, on described. One our goals this work highlight need for assessment speciation, so beneficial toxic species might be identified mechanisms action elucidated.
Язык: Английский
Процитировано
3
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11775 - 11775
Опубликована: Ноя. 1, 2024
We discussed and summarized the latest data from global literature on action of polyphenolic antioxidants their metal complexes. The review also includes a summary outcomes theoretical computations our many years experimental experience. employed various methods, including spectroscopy (FT-IR, FT-Raman, NMR, UV/Vis), X-ray diffraction, thermal analysis, quantum calculations, biological assays (DPPH, ABTS, FRAP, cytotoxicity, genotoxicity tests). According to research, number position hydroxyl groups in aromatic rings, as well delocalization electron charge conjugated double bonds, have major impact antioxidant effectiveness studied compounds. Another important factor is complexation, whereby high ionic potential metals (e.g., Fe(III), Cr(III), Cu(II)) enhance properties by stabilizing charge, while low Ag(I), Hg(II), Pb(II)) reduce efficacy disrupting distribution. However, we observed no simple correlation between capacity. This paper gives insights that will aid identifying new, effective antioxidants, which are vital for nutrition prevention neurodegenerative illnesses. Our results outline connections activity molecular structure, offering foundation methodical design antioxidants. shows detail how use complementary methods assess electronic systems ligands. approach moves beyond traditional "trial error" method, allowing more efficient rational development future
Язык: Английский
Процитировано
12
Pharmaceuticals, Год журнала: 2023, Номер 17(1), С. 12 - 12
Опубликована: Дек. 21, 2023
Repurposing drugs by uncovering new indications for approved accelerates the process of establishing treatments and reduces high costs drug discovery development. Metal complexes with clinically allow further opportunities in cancer therapy—many vanadium compounds have previously shown antitumor effects, which makes a suitable metal to complex therapeutic drugs, potentially improving their efficacy treatment. In this review, covering last 25 years research field, we identified non-oncology-approved as ligands obtain different complexes. Metformin-decavanadate, vanadium-bisphosphonates, vanadyl(IV) non-steroidal anti-inflammatory cetirizine imidazole-based oxidovanadium(IV) complexes, each has parent known medicinal properties indications, all showed potential novel anticancer treatments. Nevertheless, precise mechanisms action these against are still not fully understood.
Язык: Английский
Процитировано
17
Chemistry - A European Journal, Год журнала: 2023, Номер 29(68)
Опубликована: Авг. 16, 2023
Two new series of complexes with pyridine-containing Schiff bases, [VV O(SALIEP)L] and O(Cl-SALIEP)L] (SALIEP=N-(salicylideneaminato)-2-(2-aminoethylpyridine; Cl-SALIEP=N-(5-chlorosalicylideneaminato)-2-(2-aminoethyl)pyridine, L=catecholato(2-) ligand) have been synthesized. Characterization by 1 H 51 V NMR UV-Vis spectroscopies confirmed that: 1) most form two major geometric isomers in solution, O(SALIEP)(DTB)] (DTB=3,5-di-tert-butylcatecholato(2-)) forms that equilibrate solution; 2) tert-butyl substituents were necessary to stabilize the reduced VIV species (EPR spectroscopy cyclic voltammetry). The pyridine moiety within base ligands significantly changed their chemical properties unsubstituted catecholate compared parent HSHED (N-(salicylideneaminato)-N'-(2-hydroxyethyl)-1,2-ethanediamine) complexes. Immediate reduction occurred for unsubstituted-catecholato VV on dissolution DMSO. By contrast, improved hydrolytic stability O(HSHED)(DTB)]. had moderate cell culture media. There was significant cellular uptake intact complex T98G (human glioblastoma) cells very good anti-proliferative activity (IC50 6.7±0.9 μM, 72 h), which approximately five times higher than non-cancerous human line, HFF-1 34±10 μM). This made a potential drug candidate treatment advanced gliomas intracranial injection.
Язык: Английский
Процитировано
15
Frontiers in Chemical Biology, Год журнала: 2025, Номер 4
Опубликована: Фев. 3, 2025
Introduction Catechol moieties are common in natural bioactive molecules, and their ability to bind metal ions is widely explored both naturally with siderophores the development of metal-based drugs. The reactivities biology activities a sterically hindered model catechol compound, 3,5-di- tert -butylcatechol (dtbH 2 ) its oxidation product -butyl- o -quinone (dtbQ), were studied cell culture medium understand better medicinal roles this class molecules. Methods Anti-proliferative dtbH dtbQ fresh aged solutions molecules two human cancer lines, T98G (glioblastoma) A549 (lung carcinoma). Electrospray mass spectrometry UV/Vis spectroscopy used study buffer medium, presence absence glutathione imidazole. Results Discussion showed high anti-proliferative activity (IC 50 < 10 μM 72 h assays) lines added ions. was observed when freshly while pre-incubation for 24 reduced 5-10-fold. This deactivation avoided biological reductant, (GSH), at physiologically relevant intracellular concentration (5.0 mM). These results explained by speciation studies (UV/Vis spectrometry) aqueous buffers, or organic solvents GSH. that redox equilibrium established between dtbQ, latter rapidly coupling GSH an oxidative manner. resultant adduct likely be responsible toxicity GSH-rich cells via oxygen-dependent radical chain reactions. Deactivation due reactions nucleophiles, such as amino acids, followed formation polymeric species. reported V(V)-catecholato complexes can combination efficient cellular uptake rapid decomposition thiol-rich environment active V(V) /dtbQ adducts thiols (mainly GSH). Slower thiol-poor extracellular environments. data show crucial not only but also ligands dissociates.
Язык: Английский
Процитировано
0
Journal of Inorganic Biochemistry, Год журнала: 2025, Номер 268, С. 112915 - 112915
Опубликована: Апрель 8, 2025
Язык: Английский
Процитировано
0
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Ноя. 22, 2024
Pancreatic cancer (PC) is a highly aggressive malignancy with rising mortality rates globally. Its diagnosis often challenging due to its asymptomatic nature in the early stages. Consequently, most patients receive poor prognosis, low survival within 5 years, as disease typically detected at an advanced stage, complicating effective treatment. Flavonoids, especially those derived from traditional Chinese herbal medicines, have attracted considerable attention for their potent anti-PC properties. This review highlights therapeutic potential of these bioactive compounds, which modulate key biological pathways, making them promising candidates PC intervention. Their mechanisms action include regulation autophagy, apoptosis, cell growth, epithelial-mesenchymal transition, and oxidative stress, well enhancing chemotherapeutic sensitivity, exerting antiangiogenic effects, potentially boosting immunomodulatory responses. The demonstrated benefits natural compounds management spurred extensive academic interest. Beyond role anti-cancer agents, flavonoids may provide both preventive advantages PC, resonating core principles medicine prevention holistic
Язык: Английский
Процитировано
3
New Journal of Chemistry, Год журнала: 2024, Номер 48(19), С. 8556 - 8568
Опубликована: Янв. 1, 2024
Replacement of phen in [VO(Narg) 2 ] induces greater π electronic delocalization, thus improving antioxidant action. However, due to its lipophilic character, cellular uptake V is increased, leading enhanced pro-oxidant and anticancer effects.
Язык: Английский
Процитировано
1
Опубликована: Апрель 23, 2024
En este trabajo de tesis se presentó la síntesis, caracterización fisicoquímica y evaluación algunas propiedades biológicas complejos coordinación obtenidos a partir compuestos bioactivos con biometales. Los fueron estudiados diferentes técnicas analiticas como: análisis elemental, espectrometría absorción atómica, termogravimétrico (TGA), espectroscopía infrarroja por transformada Fourier (FTIR), paramagnética electrónica (EPR), espectrofotometría electrónica, resonancia magnética nuclear (RMN), conductividad molar fluorescencia. Respecto su actividad biológica, en primer lugar, presentaron tres flavanona glicosilada naringina el catión oxidovanadio(IV), para esta serie evaluó antioxidante frente radicales libres como superóxido, hidroxilo, peroxilo DPPH, también anticancerígena células derivadas adenocarcinoma pulmón humano (A549) sus mecanismos acción generación especies reactivas oxígeno (EROs), depleción del endógeno glutatión (GSH), cambio potencial membrana mitocondrial, vanadio intracelular. Además estudió interacción proteína plasmática albúmina sérica bovina. segundo estudio un compuesto obtenido medicamento antihipertensivo olmesartán Zn(II), este, antihipertensiva in vivo empleando ratas espontáneamente hipertensas (SHR), además, evaluaron los efectos sobre hipertrofia cardíaca, fibrosis cardíaca función ecocardiografía transtorácica, determinaciones ex vivo, igual modo, efecto estrés oxidativo oxígeno, niveles daño medido ácido tiobarbitúrico (TBARs). Este mostró cómo complejación metales interés biológico cationes V(IV) Zn(II) supone una estrategia prometedora diseño nuevos farmacológico mejorado respecto partida. Además, modulación estado redox enfoque alentador tratamiento enfermedades crónicas cáncer o hipertensión, las cuales tienen común desequilibrios naturaleza.
Процитировано
0