Silver N-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents DOI Creative Commons
Jessica Ceramella, Alessia Catalano, Annaluisa Mariconda

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 18(1), P. 9 - 9

Published: Dec. 25, 2024

The strict connections/interactions between microbial infections and cancer are nowadays widely accepted. Hence, the dual (or multiple) targeting of is an essential issue to be addressed. In this context, metal complexes have gained considerable importance effectiveness in medicinal chemistry. Particularly, N-heterocyclic carbene (NHC) with transition metals emerged as very promising compounds. Among myriad NHC–metal complexes, those bearing silver will subject review. Numerous Ag(I)-NHC revealed high antibacterial and/or anticancer properties, even higher than reference drugs. Herein, we summarize most recent studies while also discussing proposed mechanism action offering interesting remark about research field. Literature databases (PubMed/MEDLINE, Scopus, Google Scholar) were used sources search literature, referring last five years.

Language: Английский

Quinizarin Gold(I) N‐Heterocyclic Carbene Complexes with Synergistic Activity Against Anthracycline‐Resistant Leukaemia Cells: Synthesis and Biological Activity Studies DOI Creative Commons
Axel Steinbrueck,

Matthew L. Reback,

Christoph Rumancev

et al.

Chemistry - A European Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

New, asymmetric quinizarin-Au(I)-NHC complexes were designed, isolated, and fully characterised including by single crystal X-ray crystallography. Cytotoxicity studies showed effective growth inhibition in HeLa cervical cancer cells with IC

Language: Английский

Citations

0
Heteroleptic (NHC/MIC) Biscarbene Ag(I) and Au(I) Complexes: Synthesis, Characterization and Catalytic Applications DOI Open Access

Francisco J. Ruiz‐Mendoza,

Emmanuel Campos‐Dominguez,

M. Guadalupe Torres‐Salazar

et al.

ChemPlusChem, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

A series of hetero-biscarbene silver(I) and gold(I) complexes the general formula [NHC-M-MIC]PF6 (NHC=imidazol-2-ylidene, MIC=1,2,3-triazol-5-ylidene) have been prepared via treatment NHC-M-Cl precursors in reaction with an situ generated mesoionic carbene (MIC). The new heteroleptic fully characterized including NMR spectroscopy, elemental analysis, melting points single crystal X-ray diffraction. derivatives were employed successfully solvent free KA2 (ketone-alkyne-amine) coupling for preparation a quaternary carbon-containing propargyl amines while, biscarbenes, demonstrated good performance A3 (aldehyde, amine, alkyne) benzylic oxidation processes under low catalyst loadings.

Language: Английский

Citations

0
Electrochemical [3+3] Annulation of Phenol and Hydrazone: Synthesis of 1,3,4-Oxadiazines DOI
Jiahui Zhang, Yang‐Yang Hu,

Yuge Ran

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

A novel [3+3] cyclization reaction between phenol and hydrazone was successfully developed under electrochemically driven conditions. This provided access to a diverse array of 1,3,4-oxadiazinane compounds in consistently high yields, reaching up 87%. Notably, the exhibited remarkable tolerance toward broad spectrum both substrates, underscoring its versatility. Moreover, protocol distinguished itself by exceptional atom step economy, facilitating efficient construction functionalized 1,3,4-oxadiazines. The synthetic utility this approach further exemplified scalability, as demonstrated gram-scale reactions, substrate scope.

Language: Английский

Citations

0
Recent Developments in the Antimicrobial Efficacy of Coinage Metal (Cu, Ag, and Au) N‐Heterocyclic Carbene Complexes DOI Creative Commons
Ngonidzashe Ruwizhi, Thishana Singh, Bernard O. Owaga

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(14)

Published: April 1, 2025

Abstract N ‐heterocyclic carbenes (NHCs) are a class of compounds known for their biological activities which the presence therapeutic metal can enhance. The discovery cisplatin as an effective anticancer metallodrug led to research into other metal‐based drugs, not only but applications such antimicrobial, antirheumatic, and antidiabetic. Since metallic silver has been have antimicrobial efficacy, Ag(I)‐NHC complexes developed enhance efficacy both NHC. In this study, we present current review activity several azolium salts corresponding NHC coinage metals (Ag, Au, Cu in order importance). We fully analyzed discussed efficacies when benchmarked against commercially available drugs. Also highlighted where studies based on structure‐activity relationships, included variations wingtip ‐substituents ligands changes type, number oxidation state ions complex.

Language: Английский

Citations

0
A Review on Chemistry and Methods of Synthesis of 1,2,4‐Triazole Derivatives DOI Open Access
Searitha Couto Rodrigues, Raphael Silva Moratório de Moraes, Gabriel Tavares de Almeida Pinto

et al.

The Chemical Record, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Abstract This review provides a comprehensive overview of research on 1,2,4‐triazoles conducted over the last fifteen years. 1,2,4‐Triazoles are highly significant in pharmaceutical industry, with numerous compounds from this class used clinically as antifungal, antiviral, antibacterial, anti‐inflammatory, and antitubercular agents. Beyond their relevance, also explores role material science agriculture. In science, gaining prominence, particularly development energetic materials (EMs), due to exceptional properties such thermal stability, coordination ability, performance comparable well‐known explosives. Their applications extend polymers, corrosion inhibitors, metal‐organic frameworks (MOFs), they play functional for sensors, catalysis, energy storage. Additionally, addresses general aspects synthetic methodologies functionalization construction 1,2,4‐triazole ring. Synthetic methods discussed include metalation synthesis, cyclization hydrazine derivatives, multicomponent reactions, amides amidines, microwave‐assisted synthesis. Given significance triazole scaffold, its synthesis has garnered considerable attention wide‐ranging across various industrial sectors.

Language: Английский

Citations

2
Selective Metal‐Coordinated Nanodrugs Based on Thiazine Moiety for Anticancer Therapeutics: Spectroscopic, Theoretical, and Molecular Docking Studies DOI
R. Fouad,

Mohammed A.N. Mahdi,

Omima M.I. Adly

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

ABSTRACT The current study involved production, comprehensive structural analysis, and physicochemical characterizing of two distinctive complexes namely, Cu( TBH ) Zn( ); donor ligand: N′‐(1‐(3,6‐dihydro‐4‐hydroxy‐2,6‐dioxo‐2H‐1,3‐thiazin‐5‐yl)ethylidene)‐2‐hydroxybenzohydrazide) using a wide range analytical methods, including elemental UV–Vis, FT‐IR, 1 HNMR spectrometry, molar conductivity magnetic susceptibility measurements, thermal analysis. According to the findings, chelation can occur through O, N, O atoms monoanionic chelator for generating mono‐nuclear chelates with tetrahedral geometry Cu (II) octahedral Zn (II). anticarcinogenic ability its coordinated compounds against human liver cancer (HepG‐2) was investigated. complex found have selective promising anticancer activity cell line, lower IC 50 (liver carcinoma line) higher (normal values than other produced standard drugs. Utilizing DFT computations, molecular structures were verified, offering detailed understanding their quantum chemical characteristics. A quantitative structure–activity relationship (QSAR) model, which illustrates association between DFT‐computed descriptors biological activities pIC , also created multiple linear regression (MLR) on synthesized as medicines. Additionally, there are no issues compounds' oral bioavailability according (ROF) Lipinski's rule five. Furthermore, docking studies CDK2 kinase been performed validate findings. our novel nanodrug exhibits considerable cytotoxic activity, prompting further into pharmacological profile exploring potential in drug development.

Language: Английский

Citations

1
When Chirality Makes the Difference: The Case of Novel Enantiopure N-Heterocyclic Carbene–Gold and –Silver Complexes DOI Creative Commons

Maria Marra,

Annaluisa Mariconda, Domenico Iacopetta

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5262 - 5262

Published: Nov. 7, 2024

-heterocyclic carbene (NHC)-gold and -silver complexes have attracted the interest of scientific community because their multiple applications versatility in being chemically modified order to improve biological properties. However, most these contain one or more chiral centers, been obtained studied as racemic mixture. In particular, concerning interesting medicinal properties, many questions about how chirality may influence properties still remain unanswered. Aiming at a better understanding, herein series enantiopure NHC-gold was synthesized, characterized biologically evaluated different vitro systems. The individuated exerted based on complexed metal specific configuration, with (

Language: Английский

Citations

1
Synthesis and Catalytic Application of Ru(II) Complexes Supported by Zwitterionic Triazol(in)ium-5-dithiocarboxylates (MIC·CS2) and Isothiocyanates (MIC·CSNPh) DOI

Amador Flores‐Ávila,

Emmanuel Campos‐Dominguez,

Adi J. Martínez-Martell

et al.

Organometallics, Journal Year: 2024, Volume and Issue: 43(22), P. 2926 - 2934

Published: Nov. 8, 2024

In recent years, NHC-derived zwitterions [NHC·CS(X)] (X = S and NR) have gained a great deal of attention owing to their various applications in fields such as organic synthesis, organometallics, more recently catalysis. this work, we report that the reaction free triarylated triazol-5-ylidenes (MIC) with equimolar amounts dithiocarboxylate isothiocyanate derivatives allows for preparation series MIC·SC2 MIC·CSNAr good yields. Their potential ligands transition metals was demonstrated by synthesis ruthenium(II) complexes general formulas [RuCl(p-cymene)(MIC·CS2)]PF6 [RuCl(p-cymene)(MIC·CNSAr)]PF6. The ruthenium were fully characterized NMR spectroscopy, X-ray crystallography, TGA, elemental analysis. new successfully applied catalysts transfer hydrogenation aldehydes ketones showing efficiency under low catalyst loadings providing excellent conversions.

Language: Английский

Citations

1
Recent advances of Schiff base metal complexes as potential anticancer agents DOI
Lin Lv, Tianpeng Zheng,

Lu Tang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 525, P. 216327 - 216327

Published: Nov. 20, 2024

Language: Английский

Citations

1
Negative effect and removal of trace amounts of 1,3-dialkylimidazolium ionic liquids in samples from biorefineries DOI Creative Commons
Anna F. Lehrhofer, Yuko Yoneda, Tran Thi Hoai

et al.

Cellulose, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Ionic liquids (ILs), based on 1,3-dialkylimidazolium cations, are frequently used solvent components or auxiliaries for various types of biomass in biorefinery approaches. Unless washing and sample preparation have been carried out very carefully, analytical samples often contain residual traces such ionic liquids. These residues can compromise the quality physicochemical analyses, as was demonstrated monosaccharide analysis after hydrolysis by gas chromatography, high-performance thin-layer ion chromatography (IC), even damage equipment, chromatographic capillaries IC electrodes. We suggest a simple procedure—short stirring with solid elemental sulfur adsorbed alumina scavenger—as pretreatment to remove interfering imidazolium IL traces. The chemistry underlying this is conversion cation corresponding, water-insoluble, neutral, volatile 1,3-dialkylimidazole-2-thiones. Given negative effect impurities, minor extension one short additional step appears be small price pay an unperturbed instrument-safe analysis. Graphical abstract

Language: Английский

Citations

1