Photoclick and Release for Spatiotemporally Localized Theranostics of Single Cells via In Situ Generation of 1,3‐Diaryl‐1H‐benzo[f]indazole‐4,9‐dione DOI Open Access
Baolin Li,

Sitong Li,

Cefei Zhang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Bioorthogonal click‐release chemistry is a cutting‐edge tool for exploring and manipulating biomolecule functions in native biological systems. However, it challenging to achieve the precise regulation or therapy of individual cells via strategies driven by proximity thermodynamics. Herein, we propose novel photoclick‐release approach based on photo‐induced cycloaddition between 4,4′‐bis( N ‐arylsydnone) C ‐bithienyl‐diarylsydnone 2‐arylamino‐naphthoquinone irradiation with 405 485 nm light. It constructs 1,3‐diaryl‐1 H ‐benzo[ f ]indazole‐4,9‐dione (BIZON) as pharmacophore while releases an arylamine fluorescence turn‐on probing. Both photoclick reagents were tailored connecting triphenyl phosphonium delivery motif enrichment mitochondria live cells. This enables intracellular release under control We then discovered that situ photo‐generated BIZON capable photosensitizing upon 520 light produce singlet oxygen inside aerobic conditions. Therefore, realized wash‐free tracking subsequent anti‐cancer efficacy at single‐cell resolution using global illumination, which provides foundation wavelength‐gated theranostics.

Language: Английский

A multifunctional ROS cascade nanoplatform enables common prosperity of O2 and H2O2 for magnetic targeting and fluorescence imaging-guided photodynamic/chemodynamic therapy DOI

Linshan Jia,

Zimeng Zhou,

Xiaotong Li

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 506, P. 160178 - 160178

Published: Jan. 1, 2025

Language: Английский

Citations

1
A Microneedle Patch Delivers Mitochondria‐ and Lysosomes‐ Dual Targeting Prodrug‐Like Photosensitizers with Regulated Photoactivity for Precise Photodynamic Therapy DOI Open Access
Zheng Liu,

Zhimin Tang,

Ying Yin

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Antitumor photodynamic therapy (PDT) faces huge challenges as selectivity and phototoxic damage, requiring delivery photosensitizers (PSs) to specifically accumulate in tumors even organelle, avoid the damage during delivery. Herein, a microneedle patch (AIE-mito-TPP@MN) containing mitochondria- lysosomes- dual targeting prodrug-like PSs (AIE-mito-TPP/AlPcSNa4) that is self-assembled by mitochondria-targeted aggregation-induced-emission molecule (AIE-mito-TPP) lysosome-targeted aluminum phthalocyanine tetrasulfonate (AlPcSNa4), developed achieve cancer-cell-organelle-specific for precise PDT with high low damage. AIE-mito-TPP/AlPcSNa4 displays activity via regulated photoactivity reduce caused "always on" PSs. Meanwhile, AIE-mito-TPP/AlPcSNa4@MN can insert into epidermis rapid tumor lesion, enhance selective accumulation cells. The higher lysosomal acidity cells facilitates disassembly promotes targeting. Under light irradiation, impairs mitochondrial function induce deeper apoptosis at dose (≈6 µg), presenting greater therapeutic efficacy than AIE-mito-TPP@MN, AlPcSNa4@MN, or intravenous injection. Moreover, presents good biocompatibility lower normal cells, well of Therefore, organelle-targeting possesses great potential selectivity.

Language: Английский

Citations

0
Cascade-recharged macrophage-biomimetic ruthenium-based nanobattery for enhanced photodynamic-induced immunotherapy DOI Creative Commons

Guoyu Xia,

Zhongxiong Fan, Qi Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 4, 2025

Photodynamic-induced immunotherapy (PDI) is often hampered by low reactive oxygen species (ROS) yield, intra-tumor hypoxia, high glutathione (GSH) concentration, and immunosuppressive microenvironment. In view of this, a ruthenium (Ru)-based nanobattery (termed as IRD) with cascade-charged (O2), ROS, photodynamic-induced coordination-driven self-assembly transition-metal Ru, photosensitizer indocyanine green (ICG), organic ligand dithiobispropionic acid (DTPA). Then, IRD camouflaged macrophage membranes to obtain IRD@M) targeting immune evasion capabilities. Upon intravenous administration, IRD@M core-shell structure, nano diameter, good stability can specifically hoard in tumor location internalize into cells. disassembly triggered GSH, the released Ru³⁺ not only catalyzes conversion endogenous hydrogen peroxide (H₂O₂) O₂ alleviate hypoxia reduce expression hypoxia-inducible factor-1α (HIF-1α), but also generates hydroxyl radicals (·OH) elevate intracellular ROS levels. This process significantly enhances photodynamic therapy (PDT) efficacy ICG. Meanwhile, DTPA downregulate overexpressed GSH elimination deriving from PDT exchange reaction thiol-disulfide bond. It found that alleviating hypoxic microenvironment synergistically efficacy, which turn cascades recharge subsequent response, improving activating systemic tumor-specific immunity. Notably, vitro vivo experimental results jointly confirm such cascade-recharged macrophage-biomimetic Ru-based achieve an obvious while minimized side effect. Taken together, this work highlights promising strategy for simple, flexible, effective immunogenic cell death (ICD) agents within PDI.

Language: Английский

Citations

0
Recent advances in nanomaterials for integrated phototherapy and immunotherapy DOI Creative Commons
Zhuqing Sun, Nannan Wang, Yelin Wu

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216608 - 216608

Published: March 27, 2025

Language: Английский

Citations

0
Optimizing mitochondrial-targeting groups of positively-charged BODIPY nanoparticles for enhanced photodynamic therapy DOI
Huixuan Qi,

Ruobing Qu,

Jiaping Shen

et al.

Materials Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 8(23), P. 3898 - 3905

Published: Jan. 1, 2024

1-Methylimidazole-modified BODIPY nanoprobes were developed for highly efficient mitochondrial targeting and enhanced photo dynamic therapy.

Language: Английский

Citations

1
Photoclick and Release for Spatiotemporally Localized Theranostics of Single Cells via In Situ Generation of 1,3‐Diaryl‐1H‐benzo[f]indazole‐4,9‐dione DOI
Baolin Li,

Sitong Li,

Cefei Zhang

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Bioorthogonal click‐release chemistry is a cutting‐edge tool for exploring and manipulating biomolecule functions in native biological systems. However, it challenging to achieve the precise regulation or therapy of individual cells via strategies driven by proximity thermodynamics. Herein, we propose novel photoclick‐release approach based on photo‐induced cycloaddition between 4,4′‐bis( N ‐arylsydnone) C ‐bithienyl‐diarylsydnone 2‐arylamino‐naphthoquinone irradiation with 405 485 nm light. It constructs 1,3‐diaryl‐1 H ‐benzo[ f ]indazole‐4,9‐dione (BIZON) as pharmacophore while releases an arylamine fluorescence turn‐on probing. Both photoclick reagents were tailored connecting triphenyl phosphonium delivery motif enrichment mitochondria live cells. This enables intracellular release under control We then discovered that situ photo‐generated BIZON capable photosensitizing upon 520 light produce singlet oxygen inside aerobic conditions. Therefore, realized wash‐free tracking subsequent anti‐cancer efficacy at single‐cell resolution using global illumination, which provides foundation wavelength‐gated theranostics.

Language: Английский

Citations

0
Photoclick and Release for Spatiotemporally Localized Theranostics of Single Cells via In Situ Generation of 1,3‐Diaryl‐1H‐benzo[f]indazole‐4,9‐dione DOI Open Access
Baolin Li,

Sitong Li,

Cefei Zhang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Bioorthogonal click‐release chemistry is a cutting‐edge tool for exploring and manipulating biomolecule functions in native biological systems. However, it challenging to achieve the precise regulation or therapy of individual cells via strategies driven by proximity thermodynamics. Herein, we propose novel photoclick‐release approach based on photo‐induced cycloaddition between 4,4′‐bis( N ‐arylsydnone) C ‐bithienyl‐diarylsydnone 2‐arylamino‐naphthoquinone irradiation with 405 485 nm light. It constructs 1,3‐diaryl‐1 H ‐benzo[ f ]indazole‐4,9‐dione (BIZON) as pharmacophore while releases an arylamine fluorescence turn‐on probing. Both photoclick reagents were tailored connecting triphenyl phosphonium delivery motif enrichment mitochondria live cells. This enables intracellular release under control We then discovered that situ photo‐generated BIZON capable photosensitizing upon 520 light produce singlet oxygen inside aerobic conditions. Therefore, realized wash‐free tracking subsequent anti‐cancer efficacy at single‐cell resolution using global illumination, which provides foundation wavelength‐gated theranostics.

Language: Английский

Citations

0