Supramolecular Thermo‐Contracting Adhesive Hydrogel with Self‐Removability Simultaneously Enhancing Noninvasive Wound Closure and MRSA‐Infected Wound Healing

Advanced Healthcare Materials, Год журнала: 2022, Номер 11(13)

Опубликована: Апрель 15, 2022

Conventional wound closure and dressing are two crucial, time-consuming but isolated principles in care. Even though tissue adhesive opens a new era for closure, the method biomaterial that can simultaneously achieve noninvasive promote healing highly appreciated. Herein, novel supramolecular poly(N-isopropylacrylamide) hybrid hydrogel composed of quaternized chitosan-graft-β-cyclodextrin, adenine, polypyrrole nanotubes via host-guest interaction hydrogen bonds is developed. The demonstrates thermal contraction 47% remaining area after 2 h at 37 ℃ adhesion 5.74 kPa, which essential multiple mechanical biological properties including suitable properties, self-healing, on-demand removal, antioxidant, hemostasis, photothermal/intrinsic antibacterial activity (higher 99% killing ratio within 5 min irradiation). In both full-thickness skin incision excision models, reveals significant 24 post-surgery. acute methicillin-resistant Staphylococcus aureus-infected assays, wounds treated with demonstrate enhanced rapid rate, mild inflammatory response, advanced angiogenesis, well-arranged collagen fibers. Altogether, results indicate promising synchronously healing.

Язык: Английский

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Injectable Double‐Crosslinked Adhesive Hydrogels with High Mechanical Resilience and Effective Energy Dissipation for Joint Wound Treatment

Advanced Functional Materials, Год журнала: 2021, Номер 32(12)

Опубликована: Дек. 1, 2021

Abstract Due to the moist environment and inevitable movement, efficient wound closure healing of vulnerable joint skin remains a great challenge. Herein, poly(γ‐glutamic acid)‐crosslinked amino‐functionalized PEGylated poly(glycerol sebacate) (γ‐PGA/PEGS‐NH 2 ) adhesive hydrogel is reported. PEGS‐NH γ‐PGA not only forms covalent amide bonds with biological tissue surfaces achieve strong adhesion but also establishes stable chemically crosslinked network in bulk hydrogels resist deformation. Furthermore, bioinspired gallic acid‐modified chitosan (CS‐GA) introduced enhance via multiple hydrogen establish dynamic physically dissipate energy. Consequently, this strongly adheres tissue, showing an six times higher than that fibrin glue comparable cyanoacrylate glue. Moreover, benefiting from high mechanical resilience effective energy dissipation, 200 cycles loading–unloading tests conducted under state full‐thickness rat incision model applied on nape further confirmed desirable performance. Combining above ideal features their good injectability shape‐adaptability complex contours, such are demonstrated be promising candidates for physiological environment.

Язык: Английский

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ROS-Scavenging Therapeutic Hydrogels for Modulation of the Inflammatory Response

ACS Applied Materials & Interfaces, Год журнала: 2021, Номер 14(20), С. 23002 - 23021

Опубликована: Дек. 28, 2021

Although reactive oxygen species (ROS) are essential for cellular processes, excessive ROS could be a major cause of various inflammatory diseases because the oxidation proteins, DNA, and membrane lipids. It has recently been suggested that amount thus regulated to treat such physiological disorders. A ROS-scavenging hydrogel is promising candidate therapeutic applications its high biocompatibility, 3D matrix, ability modified. Approaches conferring antioxidant properties normal hydrogels include embedding catalytic nanoparticles, modifying polymer chains with ROS-adsorbing organic moieties, incorporating ROS-labile linkers in backbones. Such can used wound healing, cardiovascular diseases, bone repair, ocular neurodegenerative eliminate oxidative stress, accelerate regeneration process, show synergetic effects other drugs or molecules. In this review, mechanisms by which generated scavenged body outlined, levels resulting stress on described. Next, mechanism scavenging explained depending agents embedded within hydrogel. Lastly, recent achievements development inflammation-associated presented.

Язык: Английский

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Physical dynamic double-network hydrogels as dressings to facilitate tissue repair

Nature Protocols, Год журнала: 2023, Номер 18(11), С. 3322 - 3354

Опубликована: Сен. 27, 2023

Язык: Английский

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Advancements in gelatin-based hydrogel systems for biomedical applications: A state-of-the-art review

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 127143 - 127143

Опубликована: Окт. 2, 2023

Язык: Английский

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Multifunctional hydrogel with reactive oxygen species scavenging and photothermal antibacterial activity accelerates infected diabetic wound healing

Acta Biomaterialia, Год журнала: 2022, Номер 155, С. 199 - 217

Опубликована: Ноя. 17, 2022

Язык: Английский

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Construction of multifunctional wound dressings with their application in chronic wound treatment

Biomaterials Science, Год журнала: 2022, Номер 10(15), С. 4058 - 4076

Опубликована: Янв. 1, 2022

Multifunctional wound dressings or smart with pro-angiogenic function, antibacterial properties, anti-inflammatory/antioxidant activity and tissue adhesion for chronic repair.

Язык: Английский

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Design the molecule structures to achieve functional advantages of hydrogel wound dressings: Advances and strategies

Composites Part B Engineering, Год журнала: 2022, Номер 247, С. 110313 - 110313

Опубликована: Окт. 4, 2022

Язык: Английский

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Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing

Composites Part B Engineering, Год журнала: 2023, Номер 266, С. 110985 - 110985

Опубликована: Сен. 9, 2023

Язык: Английский

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Self-Healing Hydrogels: From Synthesis to Multiple Applications

ACS Materials Letters, Год журнала: 2023, Номер 5(7), С. 1787 - 1830

Опубликована: Май 26, 2023

Due to the good reliability and long-term stability, self-healing hydrogels have emerged as promising soft materials for tissue engineering, smart wearable sensors, bioelectronics, energy storage devices. The mechanism depends on reversible chemical or physical cross-linking interactions. Self-healing with fascinating features (including mechanical performances, biocompatibility, conductivity, antibacterial ability, responsiveness, etc.) are being designed developed according practical application requirements. In this review, recent progress in their synthesis strategies multiple applications is summarized. Their involve processes a combination of two. include flexible strain supercapacitors, actuators, adhesives, wound healing, drug delivery, tumor treatment, 3D printing, etc. Finally, current challenges, future development, opportunities discussed.

Язык: Английский

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