Gels,
Journal Year:
2024,
Volume and Issue:
10(1), P. 43 - 43
Published: Jan. 5, 2024
The
care
and
rehabilitation
of
acute
chronic
wounds
have
a
significant
social
economic
impact
on
patients
global
health.
This
burden
is
primarily
due
to
the
adverse
effects
infections,
prolonged
recovery,
associated
treatment
costs.
Chronic
can
be
treated
with
variety
approaches,
which
include
surgery,
negative
pressure
wound
therapy,
dressings,
hyperbaric
oxygen
therapy.
However,
each
these
strategies
has
an
array
limitations.
existing
dry
dressings
lack
functionality
in
promoting
healing
exacerbating
pain
by
adhering
wound.
Hydrogels,
are
commonly
polymer-based
swell
water,
been
proposed
as
potential
remedies
their
ability
provide
moist
environment
that
facilitates
healing.
Their
unique
composition
enables
them
absorb
exudates,
exhibit
shape
adaptability,
modified
incorporate
active
compounds
such
growth
factors
antibacterial
compounds.
review
provides
updated
discussion
leading
natural
synthetic
hydrogels
utilized
healing,
details
latest
advancements
hydrogel
technology,
explores
alternate
approaches
this
field.
Search
engines
Scopus,
PubMed,
Science
Direct,
Web
were
advances
applications
over
last
fifteen
years.
Advanced Healthcare Materials,
Journal Year:
2022,
Volume and Issue:
11(13)
Published: April 15, 2022
Conventional
wound
closure
and
dressing
are
two
crucial,
time-consuming
but
isolated
principles
in
care.
Even
though
tissue
adhesive
opens
a
new
era
for
closure,
the
method
biomaterial
that
can
simultaneously
achieve
noninvasive
promote
healing
highly
appreciated.
Herein,
novel
supramolecular
poly(N-isopropylacrylamide)
hybrid
hydrogel
composed
of
quaternized
chitosan-graft-β-cyclodextrin,
adenine,
polypyrrole
nanotubes
via
host-guest
interaction
hydrogen
bonds
is
developed.
The
demonstrates
thermal
contraction
47%
remaining
area
after
2
h
at
37
℃
adhesion
5.74
kPa,
which
essential
multiple
mechanical
biological
properties
including
suitable
properties,
self-healing,
on-demand
removal,
antioxidant,
hemostasis,
photothermal/intrinsic
antibacterial
activity
(higher
99%
killing
ratio
within
5
min
irradiation).
In
both
full-thickness
skin
incision
excision
models,
reveals
significant
24
post-surgery.
acute
methicillin-resistant
Staphylococcus
aureus-infected
assays,
wounds
treated
with
demonstrate
enhanced
rapid
rate,
mild
inflammatory
response,
advanced
angiogenesis,
well-arranged
collagen
fibers.
Altogether,
results
indicate
promising
synchronously
healing.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
32(12)
Published: Dec. 1, 2021
Abstract
Due
to
the
moist
environment
and
inevitable
movement,
efficient
wound
closure
healing
of
vulnerable
joint
skin
remains
a
great
challenge.
Herein,
poly(γ‐glutamic
acid)‐crosslinked
amino‐functionalized
PEGylated
poly(glycerol
sebacate)
(γ‐PGA/PEGS‐NH
2
)
adhesive
hydrogel
is
reported.
PEGS‐NH
γ‐PGA
not
only
forms
covalent
amide
bonds
with
biological
tissue
surfaces
achieve
strong
adhesion
but
also
establishes
stable
chemically
crosslinked
network
in
bulk
hydrogels
resist
deformation.
Furthermore,
bioinspired
gallic
acid‐modified
chitosan
(CS‐GA)
introduced
enhance
via
multiple
hydrogen
establish
dynamic
physically
dissipate
energy.
Consequently,
this
strongly
adheres
tissue,
showing
an
six
times
higher
than
that
fibrin
glue
comparable
cyanoacrylate
glue.
Moreover,
benefiting
from
high
mechanical
resilience
effective
energy
dissipation,
200
cycles
loading–unloading
tests
conducted
under
state
full‐thickness
rat
incision
model
applied
on
nape
further
confirmed
desirable
performance.
Combining
above
ideal
features
their
good
injectability
shape‐adaptability
complex
contours,
such
are
demonstrated
be
promising
candidates
for
physiological
environment.
ACS Applied Materials & Interfaces,
Journal Year:
2021,
Volume and Issue:
14(20), P. 23002 - 23021
Published: Dec. 28, 2021
Although
reactive
oxygen
species
(ROS)
are
essential
for
cellular
processes,
excessive
ROS
could
be
a
major
cause
of
various
inflammatory
diseases
because
the
oxidation
proteins,
DNA,
and
membrane
lipids.
It
has
recently
been
suggested
that
amount
thus
regulated
to
treat
such
physiological
disorders.
A
ROS-scavenging
hydrogel
is
promising
candidate
therapeutic
applications
its
high
biocompatibility,
3D
matrix,
ability
modified.
Approaches
conferring
antioxidant
properties
normal
hydrogels
include
embedding
catalytic
nanoparticles,
modifying
polymer
chains
with
ROS-adsorbing
organic
moieties,
incorporating
ROS-labile
linkers
in
backbones.
Such
can
used
wound
healing,
cardiovascular
diseases,
bone
repair,
ocular
neurodegenerative
eliminate
oxidative
stress,
accelerate
regeneration
process,
show
synergetic
effects
other
drugs
or
molecules.
In
this
review,
mechanisms
by
which
generated
scavenged
body
outlined,
levels
resulting
stress
on
described.
Next,
mechanism
scavenging
explained
depending
agents
embedded
within
hydrogel.
Lastly,
recent
achievements
development
inflammation-associated
presented.
Biomaterials Science,
Journal Year:
2022,
Volume and Issue:
10(15), P. 4058 - 4076
Published: Jan. 1, 2022
Multifunctional
wound
dressings
or
smart
with
pro-angiogenic
function,
antibacterial
properties,
anti-inflammatory/antioxidant
activity
and
tissue
adhesion
for
chronic
repair.
ACS Materials Letters,
Journal Year:
2023,
Volume and Issue:
5(7), P. 1787 - 1830
Published: May 26, 2023
Due
to
the
good
reliability
and
long-term
stability,
self-healing
hydrogels
have
emerged
as
promising
soft
materials
for
tissue
engineering,
smart
wearable
sensors,
bioelectronics,
energy
storage
devices.
The
mechanism
depends
on
reversible
chemical
or
physical
cross-linking
interactions.
Self-healing
with
fascinating
features
(including
mechanical
performances,
biocompatibility,
conductivity,
antibacterial
ability,
responsiveness,
etc.)
are
being
designed
developed
according
practical
application
requirements.
In
this
review,
recent
progress
in
their
synthesis
strategies
multiple
applications
is
summarized.
Their
involve
processes
a
combination
of
two.
include
flexible
strain
supercapacitors,
actuators,
adhesives,
wound
healing,
drug
delivery,
tumor
treatment,
3D
printing,
etc.
Finally,
current
challenges,
future
development,
opportunities
discussed.
