Advanced Materials,
Год журнала:
2023,
Номер
35(38)
Опубликована: Июнь 4, 2023
Abstract
With
the
promotion
of
nanochemistry
research,
large
numbers
nanomaterials
have
been
applied
in
vivo
to
produce
desirable
cytotoxic
substances
response
endogenous
or
exogenous
stimuli
for
achieving
disease‐specific
therapy.
However,
performance
is
a
critical
issue
that
difficult
improve
and
optimize
under
biological
conditions.
Defect‐engineered
nanoparticles
become
most
researched
hot
materials
biomedical
applications
recently
due
their
excellent
physicochemical
properties,
such
as
optical
properties
redox
reaction
capabilities.
Importantly,
can
be
easily
adjusted
by
regulating
type
concentration
defects
without
requiring
other
complex
designs.
Therefore,
this
tutorial
review
focuses
on
defect
engineering
briefly
discusses
classification,
introduction
strategies,
characterization
techniques.
Several
representative
defective
are
especially
discussed
order
reveal
relationship
between
properties.
A
series
disease
treatment
strategies
based
engineered
summarized.
By
summarizing
design
application
nanomaterials,
simple
but
effective
methodology
provided
researchers
therapeutic
effects
nanomaterial‐based
platforms
from
science
perspective.
Advanced Materials,
Год журнала:
2023,
Номер
35(25)
Опубликована: Янв. 12, 2023
Abstract
Emerging
piezocatalysts
have
demonstrated
their
remarkable
application
potential
in
diverse
medical
fields.
In
addition
to
ultrahigh
catalytic
activities,
inherent
and
unique
charge‐carrier‐releasing
properties
can
be
used
initiate
various
redox
reactions,
displaying
bright
prospects
for
future
applications.
Triggered
by
mechanical
energy,
piezocatalytic
materials
release
electrons/holes,
catalyze
reactions
of
substrates,
or
intervene
biological
processes
promote
the
production
effector
molecules
purposes,
such
as
decontamination,
sterilization,
therapy.
Such
a
piezocatalysis
is
termed
medicine
(PCM)
herein.
To
pioneer
novel
technologies,
especially
therapeutic
modalities,
this
review
provides
an
overview
state‐of‐the‐art
research
progress
medicine.
First,
principle
preparation
methodologies
piezoelectric
are
introduced.
Then,
comprehensive
summary
applications
tumor
treatment,
antisepsis,
organic
degradation,
tissue
repair
regeneration,
biosensing
provided.
Finally,
main
challenges
perspectives
discussed
proposed,
expecting
fuel
development
emerging
scientific
discipline.
ACS Nano,
Год журнала:
2023,
Номер
17(8), С. 7901 - 7910
Опубликована: Апрель 13, 2023
The
regulation
of
electrostatic
electric
fields
through
electrical
stimulation
is
an
efficient
method
to
increase
the
catalytic
activity
nanozymes
and
improve
therapeutic
effect
nanozyme
therapy.
Piezoelectric
materials,
which
are
capable
generating
a
built-in
field
under
ultrasound
(US),
not
only
but
also
enable
piezoelectric
sonodynamic
therapy
(SDT).
In
this
study,
sonosensitizer
based
on
Hf-based
metal–organic
framework
(UIO-66)
Au
nanoparticles
(NPs)
was
produced.
Under
US
irradiation,
UIO-66
can
generate
inside
promotes
electron–hole
separation
produces
reactive
oxygen
species
(ROS).
introduction
NPs
facilitated
electron
transfer,
inhibited
recombination
pairs
improved
properties
UIO-66.
value
constant
(d33)
increased
from
71
122
pmV–1
after
deposition
NPs.
addition,
intrinsic
catalase
peroxidase
activities
were
2-fold
induced
exposure.
vivo
in
vitro
experiments
revealed
that
proposed
kill
cancer
cells
inhibit
tumor
growth
mice
enhanced
SDT
sensitizer
work
proved
be
candidate
used
for
multiple
modalities
Advanced Materials,
Год журнала:
2023,
Номер
36(3)
Опубликована: Окт. 16, 2023
Abstract
Piezoelectric,
pyroelectric,
and
ferroelectric
materials
are
considered
unique
biomedical
due
to
their
dielectric
crystals
asymmetric
centers
that
allow
them
directly
convert
various
primary
forms
of
energy
in
the
environment,
such
as
sunlight,
mechanical
energy,
thermal
into
secondary
electricity
chemical
energy.
These
possess
exceptional
conversion
ability
excellent
catalytic
properties,
which
have
led
widespread
usage
within
fields.
Numerous
applications
demonstrated
great
potential
with
these
materials,
including
disease
treatment,
biosensors,
tissue
engineering.
For
example,
piezoelectric
used
stimulate
cell
growth
bone
regeneration,
while
pyroelectric
applied
skin
cancer
detection
imaging.
Ferroelectric
even
found
use
neural
implants
record
electrical
activity
brain.
This
paper
reviews
relationship
between
ferroelectric,
piezoelectric,
effects
fundamental
principles
different
reactions.
It
also
highlights
preparation
methods
three
significant
progress
made
applications.
The
review
concludes
by
presenting
key
challenges
future
prospects
for
efficient
catalysts
based
on
nanomaterials
Progress in Materials Science,
Год журнала:
2023,
Номер
138, С. 101161 - 101161
Опубликована: Июль 16, 2023
Piezocatalysis,
an
evolving
catalytic
technology
built
on
the
piezoelectric
properties
of
catalysts,
breaks
down
barrier
between
mechanical
energy
and
chemical
energy.
The
potential
difference
that
arises
from
deformation
a
material
is
commonly
termed
'piezopotential'.
Piezopotential
has
been
demonstrated
to
facilitate
manipulation
band
structure
and/or
charge
carrier
separation.
Despite
significant
efforts
design
materials
understand
mechanism
piezoelectrically
enhanced
chemistry
through
semiconductor
physics,
there
remains
opportunity
review
relationships
performance
piezo/ferroelectric
properties.
Herein,
we
provide
comprehensive
summary
mechanisms
correlated
physical
in
field
piezocatalysis.
A
fundamental
understanding
structural
based
solid-state
physics
can
be
used
shed
light
future
development
In
addition,
types
materials,
strategies
for
catalysis
efficiency
enhancement,
up-to-date
applications
environment
remediation,
renewable
conversion,
biomedicine
biotechnology
are
discussed.
Finally,
perspectives
designing
developing
highly
active
piezocatalysts
using
guidelines
physicochemical
proposed.
Abstract
With
the
development
of
engineered
nanomaterials
and
nanomedicines,
utilization
to
generate
excessive
reactive
oxygen
species
under
exogenous
ultrasound
(US)
irradiation
for
realizing
disease
therapy,
namely
sonodynamic
therapy
(SDT),
has
attracted
widespread
attention.
Compared
with
traditional
photodynamic
US
shows
deeper
tissue
penetration
reach
deep‐seated
location.
However,
high‐efficiency
sonosensitizers
remains
one
gravest
challenges
in
current
related
research
future
clinical
application.
Latterly,
benefiting
from
piezotronic
piezo‐phototronic
effects,
novel
based
on
piezoelectric
semiconductor
(PS)
have
exhibited
inspiring
application
prospects
SDT.
In
this
review,
we
outline
structures
physicochemical
properties
PS
that
potential
applications
SDT,
introduce
presumed
mechanisms
Then,
latest
progress
as
cancer
antibacterial
are
summarized.
Finally,
existing
trends
field
prospected.
Abstract
Piezocatalysis
is
an
emerging
technique
that
holds
great
promise
for
the
conversion
of
ubiquitous
mechanical
energy
into
electrochemical
through
piezoelectric
effect.
However,
energies
in
natural
environment
(such
as
wind
energy,
water
flow
and
noise)
are
typically
tiny,
scattered,
featured
with
low
frequency
power.
Therefore,
a
high
response
to
these
tiny
critical
achieving
piezocatalytic
performance.
In
comparison
nanoparticles
or
1D
materials,
2D
materials
possess
characteristics
such
flexibility,
easy
deformation,
large
surface
area,
rich
active
sites,
showing
more
future
practical
applications.
this
review,
state‐of‐the‐art
research
progresses
on
their
applications
piezocatalysis
provided.
First,
detailed
description
offered.
Then
comprehensive
summary
presented
examines
various
fields,
including
environmental
remediation,
small‐molecule
catalysis,
biomedicine.
Finally,
main
challenges
prospects
discussed.
It
expected
review
can
fuel
application
piezocatalysis.
Abstract
Bone
defects
are
encountered
substantially
in
clinical
practice,
and
bionic
scaffolds
represent
a
promising
solution
for
repairing
bone
defects.
However,
it
is
difficult
to
fabricate
with
structures
reconstruct
the
microenvironment
fulfill
satisfying
repair
effects.
In
this
review
article,
we
first
discuss
various
strategies
design
construction
of
promote
defect
repair,
especially
including
structural
scaffold
integration
bioactive
substances
together
application
external
stimuli.
We
then
roles
artificial
intelligence
medical
imaging
aiding
treatment.
Finally,
point
out
challenges
future
outlooks
developing
multifunctional
scaffolds,
aiming
provide
insights
improving
regeneration
efficacy
accelerating
translation.
Materials Today Bio,
Год журнала:
2023,
Номер
19, С. 100559 - 100559
Опубликована: Янв. 21, 2023
With
the
widespread
prevalence
of
drug-resistant
pathogens,
traditional
antibiotics
have
limited
effectiveness
and
do
not
yield
desired
outcomes.
Recently,
alternative
antibacterial
therapies
based
on
ultrasound
(US)
been
explored
to
overcome
crisis
bacterial
pathogens.
Antimicrobial
sonodynamic
therapy
(aSDT)
offers
an
excellent
solution
that
relies
US
irradiation
produce
reactive
oxygen
species
(ROS)
achieve
antibiotic-free
mediated
antimicrobial
effects.
In
addition,
aSDT
possesses
advantage
superior
tissue
penetrability
compared
light
irradiation,
demonstrating
great
feasibility
in
treating
deep
infections.
Although
existing
conventional
sonosensitizers
can
ROS
for
activity,
some
limitations,
such
as
low
penetration
rate,
nonspecific
distribution
poor
production
under
hypoxic
conditions,
result
suboptimal
sterilization
aSDT.
emerging
nanosonosensitizers
enormous
advantages
high-performance
agents
aSDT,
which
deficiencies
described
above.
Thus,
nanosonosensitizer-mediated
has
a
bright
future
management
This
review
classifies
current
available
provides
overview
mechanisms,
biomedical
applications,
recent
advances
perspectives
