Chemical Engineering and Processing - Process Intensification, Год журнала: 2023, Номер 194, С. 109602 - 109602
Опубликована: Ноя. 5, 2023
Язык: Английский
Materials Horizons, Год журнала: 2024, Номер 11(12), С. 2820 - 2855
Опубликована: Янв. 1, 2024
A systematic summary of fabrication technologies, a variety structures and biomedical applications polymeric microspheres.
Язык: Английский
Процитировано
23
European Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 194, С. 106704 - 106704
Опубликована: Янв. 14, 2024
Microparticles have unique benefits in the formulation of multiparticulate and multi-unit type pharmaceutical dosage forms allowing improved drug safety efficacy with favorable pharmacokinetics patient centricity. On other hand, above advantages are served by high well reproducible quality attributes medicinal product where even flexible design controlled processability offer success as possible longer life-cycle for manufacturers. Moreover, specific demands patients can be taken into account, including simplified dosing regimens, dosage, combinations, palatability, ease swallowing. In more than 70 years since first modified-release appeared on market, many new formulations been marketed publications literature. More newer technologies excipients become available producing tailor-made particles micrometer dimensions beyond. All these contributed to fact that sub-units (e.g. minitablets, pellets, microspheres) make up a system vary widely composition properties. Some units mucoadhesive properties others float contribute suitable release profile designed formula whole. Nowadays, there some which able active substance several months (3 or 6 depending treatment). this review, latest developments used long time presented, innovative solutions such applicability 3D printing produce subunits systems. Furthermore, diversity systems, different routes administration also touching ones capable carrying relevant, commercially multiparticle-based medical devices. The versatility size from 1 µm multiplicity promise solid foundation future applications form development.
Язык: Английский
Процитировано
20
Separation and Purification Technology, Год журнала: 2023, Номер 330, С. 125435 - 125435
Опубликована: Окт. 21, 2023
Язык: Английский
Процитировано
32
Fuel, Год журнала: 2023, Номер 361, С. 130604 - 130604
Опубликована: Дек. 20, 2023
Язык: Английский
Процитировано
31
Global Challenges, Год журнала: 2023, Номер 7(9)
Опубликована: Авг. 11, 2023
Abstract The remarkable control function over the functional material formation process enabled by droplet microfluidic emulsification approaches can lead to efficient and one‐step encapsulation of active substances in microparticles, with microparticle characteristics well regulated. In comparison conventional fabrication methods, technology not only construct microparticles various shapes, but also provide excellent templates, which enrich expand application fields microparticles. For instance, intersection disciplines pharmacy, life sciences, others, modifying structure microspheres appending materials be completed preparation as‐prepared polymer particles have great potential a wide range applications for chemical analysis, heavy metal adsorption, detection. This review systematically introduces devices basic principles particle using discusses research high monodispersity, involving plethora types including spherical, nonspherical, Janus type, as core–shell, hole–shell, controllable multicompartment particles. Moreover, this paper exhibits critical analysis current status existing challenges, outlook future development emerging has been discussed.
Язык: Английский
Процитировано
24
Chemical Engineering and Processing - Process Intensification, Год журнала: 2024, Номер 198, С. 109729 - 109729
Опубликована: Март 1, 2024
Язык: Английский
Процитировано
15
Small, Год журнала: 2024, Номер unknown
Опубликована: Июнь 16, 2024
Abstract Stem cell‐related therapeutic technologies have garnered significant attention of the research community for their multi‐faceted applications. To promote effects stem cells, strategies cell microencapsulation in hydrogel microparticles been widely explored, as potential to facilitate oxygen diffusion and nutrient transport alongside ability crucial cell‐cell cell‐matrix interactions. Despite promise, there is an acute shortage automated, standardized, reproducible platforms further research. Microfluidics offers intriguing platform produce cell‐laden (SCHMs) owing its manipulate fluids at micrometer scale well precisely control structure composition microparticles. In this review, typical biomaterials crosslinking methods microfluidic encapsulation cells progress droplet‐based microfluidics fabrication SCHMs are outlined. Moreover, important biomedical applications highlighted, including regenerative medicine, tissue engineering, scale‐up production microenvironmental simulation fundamental studies. Overall, holds tremendous enabling diverse worthy various
Язык: Английский
Процитировано
14
Expert Opinion on Drug Delivery, Год журнала: 2025, Номер unknown, С. 1 - 20
Опубликована: Янв. 7, 2025
Introduction The pursuit of linear dosage in pharmacy is essential for achieving consistent therapeutic release and enhancing patient compliance. This review provides a comprehensive summary zero-order drug delivery systems, with particular focus on reservoir-based systems emanated from different microfabrication technologies.
Язык: Английский
Процитировано
2
Journal of Colloid and Interface Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(13), С. 17195 - 17210
Опубликована: Март 24, 2023
We report a Lego-inspired glass capillary microfluidic device capable of encapsulating both organic and aqueous phase change materials (PCMs) with high reproducibility 100% PCM yield. Oil-in-oil-in-water (O/O/W) water-in-oil-in-water (W/O/W) core-shell double emulsion droplets were formed to encapsulate hexadecane (HD, an PCM) salt hydrate SP21EK (an in UV-curable polymeric shell, Norland Optical Adhesive (NOA). The emulsions consolidated through on-the-fly polymerization, which followed thiol-ene click chemistry for photoinitiation. particle diameters shell thicknesses the microcapsules controlled by manipulating geometry capillaries fluid flow rates. monodispersed exhibited highest encapsulation efficiencies 65.4 44.3% HD SP21EK-based materials, respectively, as determined using differential scanning calorimetry (DSC). thermogravimetric (TGA) analysis confirmed much higher thermal stability encapsulated PCMs compared pure PCMs. Polarization microscopy revealed that could sustain over 100 melting-crystallization cycles without any structural changes. Bifunctional remarkable photocatalytic activity along energy storage performance produced after addition 1 wt % titanium dioxide (TiO2) nanoparticles (NPs) into shell. presence TiO2 NPs was opacity whiteness these quantified dispersive X-ray (EDX) spectroscopy. Young's modulus HD-based estimated micromanipulation increased from 58.5 224 MPa incorporation
Язык: Английский
Процитировано
17