Advances in Colloid and Interface Science, Год журнала: 2025, Номер unknown, С. 103496 - 103496
Опубликована: Март 1, 2025
Язык: Английский
Advanced Functional Materials, Год журнала: 2023, Номер 33(26)
Опубликована: Март 25, 2023
Abstract When skin trauma occurs, rapid achievement of the post‐wound closure is required to prevent microbial invasion, inhibit scar formation and promote wound healing. To develop a dressing for accelerating post‐wound‐closure healing, thermo‐responsive tissue‐adhesive hydrogel with interpenetrating polymer networks (IPN) fabricated based on N ‐dimethylbisacrylamide (NIPAM) glutaraldehyde (GTA) cross‐linked hyaluronic acid (HA). Results not only confirm thermo‐stimulated self‐contraction tissue adhesiveness HA‐based IPN (PNI‐HA), which effectively aids via mechanical stretch, but also verify hemocompatibility cytocompatibility PNI‐HA that tend accelerate In vivo, mouse model total defect demonstrates acting as sealant significantly achieves sutureless at early stage then promotes healing by reducing inflammatory cells infiltration, promoting angiogenesis well collagen deposition. These results indicate developed offers candidate serve
Язык: Английский
Процитировано
107
Advanced Functional Materials, Год журнала: 2024, Номер 34(32)
Опубликована: Май 6, 2024
Abstract Conductive hydrogels are gaining significant attention as promising candidates for the fabrication materials flexible electronics. Nevertheless, improving tensile properties, hysteresis, durability, adhesion, and electrochemical properties of these remains challenging. This work reports development a novel semi‐interpenetrating network poly(ionic liquid) hydrogel named PATV, via in situ polymerization acrylamide, N ‐[Tris(hydroxymethyl)methyl] 1‐vinyl‐3‐butylimidazolium tetrafluoroborate. The density functional theory calculations reveal that acts physical cross–linking points to construct hydrogen‐bond networks. Furthermore, networks dissipate energy efficiently quickly, thus stress concentration hysteresis avoided. prepared has low (9%), high (900%), fast response (180 ms), sensitivity (gauge factor = 10.4, pressure 0.14 kPa −1 ), wide sensing range (tensile range: 1–600%, compression 0.1–20 kPa). A multifunctional sensor designed based on enables real‐time, rapid, stable response‐ability detection human movement, facial expression recognition, pronunciation, pulse, handwriting, Morse code encryption. assembled triboelectric nanogenerator displays an excellent harvesting capability, highlighting its potential application self‐powered wearable electronic devices.
Язык: Английский
Процитировано
49
Advanced Functional Materials, Год журнала: 2024, Номер 34(36)
Опубликована: Апрель 27, 2024
Abstract An asymmetrical wound dressing functions akin to human skin by serving as a protective barrier between and its immediate environment. However, significant challenges persist concerning the robust adhesion properties of hydrogels, particularly when applied in emergency hemostasis healing contexts. Herein, study has successfully synthesized hydrogel patches with Janus asymmetric‐adhesion, denoted HGO‐C, exclusively comprised natural polymers. This achievement is realized through assembly adhesive (HGO) non‐adhesive (CGC), thereby amalgamating their distinct functionalities. The component served physical shield safeguarding against contamination, while hydrogel, contacted surface, firmly adhered it, swiftly arresting bleeding facilitating healing. Cytocompatibility tests, hemolysis antibacterial assays, coagulation assays demonstrated excellent biocompatibility, antibacterial, hemostatic HGO‐C. Finally, vivo experiments, including liver hemorrhage assay assay, unequivocally showed rapid enhanced capabilities Consequently, these distinctive patches, derived from polymers characterized asymmetric properties, may have great potential for real‐life usage clinical patients.
Язык: Английский
Процитировано
47
Carbohydrate Polymers, Год журнала: 2024, Номер 334, С. 122064 - 122064
Опубликована: Март 15, 2024
Язык: Английский
Процитировано
32
ACS Nano, Год журнала: 2024, Номер 18(22), С. 14207 - 14217
Опубликована: Май 20, 2024
Abnormal secretion and dysrhythmias of cortisol (CORT) are associated with various diseases such as sleep disorders, depression, chronic fatigue. Wearable devices a cutting-edge technology for point-of-care detection dynamic monitoring CORT inspiring convenience. Herein, we developed minimally invasive skin-worn device the advanced integration both interstitial fluid (ISF) sampling target molecule sensing simultaneous via microneedle-based sensor high sensitivity, excellent efficiency, outstanding reproducibility. In microneedle patch, swellable hydrogel was employed adsorption matrix ISF extraction. Meanwhile, europium metal–organic frameworks (Eu-MOF) wrapped in played vital role recognition quantitative analysis. The wearable label-free Eu-MOF-loaded patch exhibited sensitivity limit reaching 10–9 M selectivity. Molecular dynamics simulation–driven mechanism exploration revealed that strong interface interaction promoted fluorescence quenching Eu-MOF. Moreover, vitro vivo investigation confirmed feasibility reliability method, biocompatibility validated. Overall, sensitive approach based on Eu-MOF (MN) established visible exciting clinical-translational ability.
Язык: Английский
Процитировано
28
Carbohydrate Polymers, Год журнала: 2024, Номер 334, С. 122014 - 122014
Опубликована: Март 4, 2024
Язык: Английский
Процитировано
26
Chemical Engineering Journal, Год журнала: 2024, Номер 493, С. 152513 - 152513
Опубликована: Май 23, 2024
Язык: Английский
Процитировано
22
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(13), С. 15970 - 15980
Опубликована: Март 19, 2024
Despite the rapid development of tissue adhesives, flaws including allergies, poor stability, and indiscriminate double-sided adhesive properties limit their application in medical field. In this work, Janus polyurethane patches were spontaneously prepared by adjusting difference functional group distribution between top bottom sides patch during emulsion drying. Consequently, adhesion was exhibited on surface, while surface can easily adhere to metals, polymers, glasses, tissues. The strength pork skin two surfaces is more than 5 times. quaternary ammonium salt hydrophilic components enable removal absorption water from achieve wet adhesion. Animal experiments have demonstrated that multifunctional promote wound closure healing infected wounds. This facile effective strategy construct provides a promising method for tissue-adhesives.
Язык: Английский
Процитировано
20
Small, Год журнала: 2024, Номер 20(23)
Опубликована: Март 10, 2024
Abstract Wounds in harsh environments can face long‐term inflammation and persistent infection, which slow healing. Wound spray is a product that be rapidly applied to large irregularly dynamic wounds, quickly form protective film situ inhibit external environmental infection. In this study, biodegradable A B combined multi‐functional hydrogel developed with methacrylate‐modified chitosan (CSMA 1st ) ferulic acid (FA) as type raw materials oxidized Bletilla striata polysaccharide (OBSP) materials. The precursor CSMA ‐FA/OBSP (CSOB‐FA formed by the self‐cross‐linking of Schiff base bonds, CSMA‐FA/OBSP (CSOB‐FA) after UV–vis light, so fits wound. Rapid spraying curing provide sufficient flexibility rapidity for wounds has good injectability, adhesive, mechanical strength. rats miniature pigs, shrink promote healing infected enrichment fibrocyte populations. Therefore, multifunctional protect irregular prevent wound infection secondary injury, used safe effective treatment, prospect development.
Язык: Английский
Процитировано
19
International Journal of Biological Macromolecules, Год журнала: 2022, Номер 228, С. 99 - 110
Опубликована: Дек. 21, 2022
Язык: Английский
Процитировано
40