International Journal of Biological Macromolecules, Год журнала: 2024, Номер 281, С. 136375 - 136375
Опубликована: Окт. 9, 2024
Язык: Английский
Nano-Micro Letters, Год журнала: 2024, Номер 17(1)
Опубликована: Ноя. 27, 2024
Abstract Bioactive molecules have shown great promise for effectively regulating various bone formation processes, rendering them attractive therapeutics regeneration. However, the widespread application of bioactive is limited by their low accumulation and short half-lives in vivo. Hydrogels emerged as ideal carriers to address these challenges, offering potential prolong retention times at lesion sites, extend vivo mitigate side effects, avoid burst release, promote adsorption under physiological conditions. This review systematically summarizes recent advances development molecule-loaded hydrogels regeneration, encompassing applications cranial defect repair, femoral periodontal regeneration with underlying diseases. Additionally, this discusses current strategies aimed improving release profiles through stimuli-responsive delivery, carrier-assisted sequential delivery. Finally, elucidates existing challenges future directions hydrogel encapsulated field
Язык: Английский
Процитировано
10
ACS Applied Polymer Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 10, 2025
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 294, С. 139418 - 139418
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
1
Bioactive Materials, Год журнала: 2025, Номер 49, С. 486 - 501
Опубликована: Март 20, 2025
Язык: Английский
Процитировано
1
Reactive and Functional Polymers, Год журнала: 2024, Номер 196, С. 105821 - 105821
Опубликована: Янв. 5, 2024
Язык: Английский
Процитировано
4
Small, Год журнала: 2025, Номер unknown
Опубликована: Фев. 21, 2025
Abstract As the global population ages, an increasing number of elderly people are experiencing weakened bone regenerative capabilities, resulting in slower repair processes and associated risks various complications. This review outlines research progress on biomaterials that promote through immunotherapy. examines how manufacturing technologies such as 3D printing, electrospinning, microfluidic technology contribute to enhancing therapeutic effects these biomaterials. Following this, it provides detailed introductions anti‐osteoporosis drug delivery systems, injectable hydrogels, nanoparticles, engineered exosomes, well tissue engineering materials coatings used immunomodulation. Moreover, critically analyzes current limitations biomaterial‐mediated immunotherapy explores future directions for material‐mediated aims inspire new approaches broaden perspectives addressing challenges aging by exploring innovative strategies.
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 32, С. 101687 - 101687
Опубликована: Март 20, 2025
Repairing bone defects in inflammatory conditions remains a significant clinical challenge. An ideal scaffold material for such situations should enable minimally invasive implantation and integrate capabilities immunomodulation, anti-infection therapy, enhanced regeneration. In this study, we developed injectable calcitriol@polydopamine@gelatin methacryloyl hydrogel microspheres (CAL@PDA@GMs) using microfluidic technology. This system facilitates the sustained release of calcitriol, which features excellent biocompatibility biodegradability, promotes osteogenesis, scavenges excessive reactive oxygen species (ROS), induces polarization macrophages from M1 to M2 phenotype, thereby mitigating lipopolysaccharide (LPS)-induced inflammation. These mechanisms work synergistically create an optimal immune microenvironment regeneration conditions. RNA sequencing (RNA-Seq) analyses revealed that immunomodulation is achieved by regulating macrophage phenotypes, inhibiting nuclear transcription factor-kappa B (NF-κB) ROS signaling pathways, reducing secretion pro-inflammatory cytokines. study proposes novel method enhance tissue remediating damaged presents potential therapeutic strategy large-scale injuries.
Язык: Английский
Процитировано
0
Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 127515 - 127515
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Biomaterials Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Optimizing the physicochemical properties of engineered bone implants enhances osseointegration and promotes regeneration by regulating local immune responses.
Язык: Английский
Процитировано
0
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 26, 2025
Abstract Native extracellular matrix exhibits multiscale groove and ridge structures that continuously change, such as collagen fibril‐based nanogrooves in bone tissue, regulate cellular responses. However, dynamic switching between nanostructures at the molecular level has not been demonstrated. Herein, materials capable of groove‐ridge tens‐of‐nanometers scale are developed by flexibly conjugating RGD‐magnetically activatable nanoridges (MANs) to non‐magnetic with independently tuned widths comparable sizes integrin‐presenting filopodia modulating hydrophobicity bicontinuous microemulsion, allowing for cyclic modulation RGD accessibility adhesion. Nanogrooves medium width restrict “groove” state which RGD‐MANs buried, is reversed magnetically raising them protrude form “ridge” fully exposes RGDs. This reversibly stimulates integrin recruitment, focal adhesion complex assembly, mechanotransduction, differentiation stem cells vivo. first demonstration molecular‐level exhibit unprecedented switchability nanostructures. Versatile tuning width, height, pitch, shape intricate nanogroove remote manipulability can enlighten understanding molecular‐scale cell–ligand interactions cell engineering‐based treatment aging, injuries, stress‐related diseases.
Язык: Английский
Процитировано
0