Macromolecular Rapid Communications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 26, 2024
Abstract
Osteoporosis
induces
severe
oxidative
stress
and
disrupts
bone
metabolism,
complicating
the
treatment
of
defects.
Current
therapies
often
have
side
effects
require
lengthy
regeneration
periods.
Hydrogels,
known
for
their
flexible
mechanical
properties
degradability,
are
promising
carriers
drugs
bioactive
factors
in
tissue
engineering.
However,
they
lack
ability
to
regulate
local
pathological
environment
osteoporosis
expedite
repair.
Polyphenols,
with
antioxidative,
anti‐inflammatory,
metabolism‐regulating
properties,
emerged
as
a
solution.
Combining
hydrogels
polyphenols,
polyphenol‐based
can
metabolism
while
providing
support
adhesion,
promoting
osteoporotic
regeneration.
This
review
first
provides
brief
overview
types
polyphenols
mechanisms
facilitating
antioxidant,
modulation
modulating
osteoporosis.
Next,
this
examines
recent
advances
defects,
including
use
angiogenesis,
modulation,
drug
delivery,
stem
cell
therapy.
Finally,
it
highlights
latest
research
on
polyphenol
defect
Overall,
aims
facilitate
clinical
application
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Nov. 27, 2024
Abstract
Bioactive
molecules
have
shown
great
promise
for
effectively
regulating
various
bone
formation
processes,
rendering
them
attractive
therapeutics
regeneration.
However,
the
widespread
application
of
bioactive
is
limited
by
their
low
accumulation
and
short
half-lives
in
vivo.
Hydrogels
emerged
as
ideal
carriers
to
address
these
challenges,
offering
potential
prolong
retention
times
at
lesion
sites,
extend
vivo
mitigate
side
effects,
avoid
burst
release,
promote
adsorption
under
physiological
conditions.
This
review
systematically
summarizes
recent
advances
development
molecule-loaded
hydrogels
regeneration,
encompassing
applications
cranial
defect
repair,
femoral
periodontal
regeneration
with
underlying
diseases.
Additionally,
this
discusses
current
strategies
aimed
improving
release
profiles
through
stimuli-responsive
delivery,
carrier-assisted
sequential
delivery.
Finally,
elucidates
existing
challenges
future
directions
hydrogel
encapsulated
field
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 21, 2025
Abstract
As
the
global
population
ages,
an
increasing
number
of
elderly
people
are
experiencing
weakened
bone
regenerative
capabilities,
resulting
in
slower
repair
processes
and
associated
risks
various
complications.
This
review
outlines
research
progress
on
biomaterials
that
promote
through
immunotherapy.
examines
how
manufacturing
technologies
such
as
3D
printing,
electrospinning,
microfluidic
technology
contribute
to
enhancing
therapeutic
effects
these
biomaterials.
Following
this,
it
provides
detailed
introductions
anti‐osteoporosis
drug
delivery
systems,
injectable
hydrogels,
nanoparticles,
engineered
exosomes,
well
tissue
engineering
materials
coatings
used
immunomodulation.
Moreover,
critically
analyzes
current
limitations
biomaterial‐mediated
immunotherapy
explores
future
directions
for
material‐mediated
aims
inspire
new
approaches
broaden
perspectives
addressing
challenges
aging
by
exploring
innovative
strategies.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
32, P. 101687 - 101687
Published: March 20, 2025
Repairing
bone
defects
in
inflammatory
conditions
remains
a
significant
clinical
challenge.
An
ideal
scaffold
material
for
such
situations
should
enable
minimally
invasive
implantation
and
integrate
capabilities
immunomodulation,
anti-infection
therapy,
enhanced
regeneration.
In
this
study,
we
developed
injectable
calcitriol@polydopamine@gelatin
methacryloyl
hydrogel
microspheres
(CAL@PDA@GMs)
using
microfluidic
technology.
This
system
facilitates
the
sustained
release
of
calcitriol,
which
features
excellent
biocompatibility
biodegradability,
promotes
osteogenesis,
scavenges
excessive
reactive
oxygen
species
(ROS),
induces
polarization
macrophages
from
M1
to
M2
phenotype,
thereby
mitigating
lipopolysaccharide
(LPS)-induced
inflammation.
These
mechanisms
work
synergistically
create
an
optimal
immune
microenvironment
regeneration
conditions.
RNA
sequencing
(RNA-Seq)
analyses
revealed
that
immunomodulation
is
achieved
by
regulating
macrophage
phenotypes,
inhibiting
nuclear
transcription
factor-kappa
B
(NF-κB)
ROS
signaling
pathways,
reducing
secretion
pro-inflammatory
cytokines.
study
proposes
novel
method
enhance
tissue
remediating
damaged
presents
potential
therapeutic
strategy
large-scale
injuries.
Biomaterials Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Optimizing
the
physicochemical
properties
of
engineered
bone
implants
enhances
osseointegration
and
promotes
regeneration
by
regulating
local
immune
responses.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 26, 2025
Abstract
Native
extracellular
matrix
exhibits
multiscale
groove
and
ridge
structures
that
continuously
change,
such
as
collagen
fibril‐based
nanogrooves
in
bone
tissue,
regulate
cellular
responses.
However,
dynamic
switching
between
nanostructures
at
the
molecular
level
has
not
been
demonstrated.
Herein,
materials
capable
of
groove‐ridge
tens‐of‐nanometers
scale
are
developed
by
flexibly
conjugating
RGD‐magnetically
activatable
nanoridges
(MANs)
to
non‐magnetic
with
independently
tuned
widths
comparable
sizes
integrin‐presenting
filopodia
modulating
hydrophobicity
bicontinuous
microemulsion,
allowing
for
cyclic
modulation
RGD
accessibility
adhesion.
Nanogrooves
medium
width
restrict
“groove”
state
which
RGD‐MANs
buried,
is
reversed
magnetically
raising
them
protrude
form
“ridge”
fully
exposes
RGDs.
This
reversibly
stimulates
integrin
recruitment,
focal
adhesion
complex
assembly,
mechanotransduction,
differentiation
stem
cells
vivo.
first
demonstration
molecular‐level
exhibit
unprecedented
switchability
nanostructures.
Versatile
tuning
width,
height,
pitch,
shape
intricate
nanogroove
remote
manipulability
can
enlighten
understanding
molecular‐scale
cell–ligand
interactions
cell
engineering‐based
treatment
aging,
injuries,
stress‐related
diseases.
