Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 12, 2024
Abstract
The
treatment
of
diabetic
wounds
remains
a
major
clinical
challenge
owing
to
bacterial
infection,
defects
in
angiogenesis,
and
the
corresponding
inhibition
cell
activity
extracellular
matrix
deposition.
In
this
study,
core-shell-type
nanosystem
was
developed
using
graphdiyne
(GDY)
nanoparticles
covered
with
gelatin
investigate
its
effects
on
wound
healing.
were
loaded
transforming
growth
factor
β
(TGF-β)
via
electrostatic
self-assembly
promote
angiogenesis
migration.
photothermal
GDY
applied
achieve
controllable
drug
release
antibacterial
properties.
This
could
rapidly
TGF-β
after
irradiation
by
near-infrared
rays
(NIR)
without
damaging
biological
activities.
associated
observed
30
seconds
nanoparticles,
temperature
set
at
safe
range
(<49.6
°C).
Besides,
gels
possessed
good
biocompatibility
promoted
migration
vitro.
After
implantation,
hydrogels
group
showed
higher
healing
rate
than
control
mouse
models
14
days
exhibited
evident
tissue
regeneration,
including
study
presents
method
for
fabricating
dressings
an
effective
NIR-response
strategy
designing
drug-delivery
nanosystems
cellular
factors.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 3, 2024
Abstract
Multifunctional
responsive
hydrogels
hold
significant
promise
for
diabetic
foot
ulcer
(DFU)
treatment,
though
their
complex
design
and
manufacturing
present
challenges.
This
study
introduces
a
novel
supramolecular
guanosine‐phenylboronic‐chlorogenic
acid
(GBC)
hydrogel
developed
using
dynamic
covalent
strategy.
The
forms
through
guanosine
quadruplex
assembly
in
the
presence
of
potassium
ions
chlorogenic
(CA)
linkage
via
borate
bonds.
GBC
exhibit
pH
glucose
responsiveness,
releasing
more
under
acidic
high
conditions
due
to
bond
dissociation
G‐quadruplex
(G4)
disintegration.
Experimental
results
indicate
that
good
self‐healing,
shear‐thinning,
injectability,
swelling
properties.
Both
vitro
vivo
studies
demonstrate
hydrogel's
biocompatibility,
ability
eliminate
bacteria
reactive
oxygen
species
(ROS),
facilitate
macrophage
polarization
from
M1
phenotype
M2
(decreasing
CD86
expression
increasing
CD206
expression),
anti‐inflammatory
effects
(reducing
TNF‐α
IL‐10
promote
angiogenesis
(increasing
VEGF,
CD31,
α‐SMA
expression).
Thus,
accelerate
DFU
healing
enhance
tissue
remodeling
collagen
deposition.
work
provides
new
approach
developing
expedite
healing.
Theranostics,
Год журнала:
2025,
Номер
15(5), С. 1760 - 1786
Опубликована: Янв. 2, 2025
Smart
biomaterials
with
active
environmental
responsiveness
have
attracted
widespread
attention
in
recent
years.
Previous
studies
on
bioactive
glass
(BG)
mainly
focused
the
property
of
bioactivity,
while
little
has
been
paid
to
smart
response
BG.
Herein,
we
propose
concept
Bioactive
Glass
Composites
(SBGC)
which
are
capable
actively
responding
endogenous
disease
microenvironment
or
exogenous
physical
stimuli,
thereby
enabling
treatment
tissue
defect
sites
and
ultimately
promoting
regeneration.
In
this
review,
characteristics
SBGC
different
internal
external
environments
described.
Subsequently,
applications
complex
repair
tumors,
infections,
diabetes
reviewed.
By
deeply
analyzing
progress
fields,
review
will
point
out
direction
for
research
next-generation
