Опубликована: Янв. 1, 2024
Язык: Английский
Food Hydrocolloids, Год журнала: 2024, Номер 159, С. 110610 - 110610
Опубликована: Сен. 6, 2024
Язык: Английский
Процитировано
6
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
Abstract Diseases caused by bacterial infections place a significant burden on global public health. Sonodynamic therapy (SDT), as an emerging antibacterial treatment, faces clinical challenges due to the non‐polar nature of most sonosensitizers. To address this, acid‐responsive zinc‐porphyrin‐based sonosensitizer (Zn‐TCPP) is developed via simple thermal reaction, which then coated with phenylboronic acid‐modified hyaluronic acid (B‐HA), fabricate B‐HA@Zn‐TCPP. While in mildly acidic microenvironment mimicking infected wound site, released B‐HA@Zn‐TCPP achieves effective SDT activity. The disruption membrane and levels intracellular reactive oxygen species (ROS) verified that inhibition rate can reach 99% within 5 min, without any development resistance after 15 consecutive generations culture. Additionally, under ultrasound (US) ‐mediated cavitation, exhibits excellent penetration into biofilms, achieving 90.04% bactericidal for bacteria biofilms. In vivo studies further demonstrated effectively accelerate healing wounds 98.65% 9 days. Therefore, novel offers viable strategy overcome limitations traditional sonosensitizers infections.
Язык: Английский
Процитировано
0
Bioactive Materials, Год журнала: 2025, Номер 48, С. 474 - 492
Опубликована: Фев. 27, 2025
Язык: Английский
Процитировано
0
Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 17
Опубликована: Март 5, 2025
Periodontitis is a chronic inflammatory disease induced by the microbiome, leading to destruction of periodontal structures and potentially resulting in tooth loss. Using local drug delivery systems as an adjunctive therapy scaling root planning periodontitis promising strategy. However, this administration method's effectiveness constrained complexity environment. Nanomaterials have demonstrated significant potential antibacterial treatment periodontitis, attributed their controllable size, shape, surface charge, high design flexibility, reactivity, specific area. In review, we summarize complex microenvironment difficulties explicitly reviewing application strategies nanomaterials with unique properties distinct periodontitis. Furthermore, review discusses limitations current research, proposes feasible solutions, explores prospects for using context.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162255 - 162255
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123577 - 123577
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
ACS Omega, Год журнала: 2024, Номер 9(40), С. 41636 - 41650
Опубликована: Сен. 25, 2024
This work addresses the problem of converting waste methane, a significant greenhouse gas, using customized nickel-zeolite catalysts to produce profitable syngas. The investigation employs 5 wt % Ni on various zeolite supports with Si/Al ratios ranging from 13 25. Comprehensive characterization methods, including temperature-programmed reduction, N
Язык: Английский
Процитировано
3
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 10, 2024
Over the past two decades, iron-based metal-organic frameworks (Fe-MOFs) have attracted significant research interest in biomedicine due to their low toxicity, tunable degradability, substantial drug loading capacity, versatile structures, and multimodal functionalities. Despite great potential, transition of Fe-MOFs-based composites from laboratory clinical products remains challenging. This review evaluates key properties that distinguish Fe-MOFs other MOFs highlights recent advances synthesis routes, surface engineering, shaping technologies. In particular, it focuses on applications biosensing, antimicrobial, anticancer therapies. addition, emphasizes need develop scalable, environmentally friendly, cost-effective production methods for additional meet specific requirements various biomedical applications. ability combine therapies, hurdles still remain, including a deeper understanding therapeutic mechanisms potential risks resistance overdose. Systematically addressing these challenges could significantly enhance prospects potentially facilitate integration into mainstream practice.
Язык: Английский
Процитировано
3
Analytica Chimica Acta, Год журнала: 2024, Номер 1338, С. 343589 - 343589
Опубликована: Дек. 25, 2024
Язык: Английский
Процитировано
3
Aggregate, Год журнала: 2024, Номер unknown
Опубликована: Сен. 28, 2024
Abstract Persistent biofilm infections pose a critical health threat with their relentless presence and amplified antibiotic resistance. Traditional antibacterial photodynamic therapy can inhibit bacteria extracellularly but struggles to control formation virulence. Thus, there is an urgent need develop photosensitizers, such as ultra‐small gold nanoclusters (AuNCs), that penetrate biofilms internalize into bacteria. However, AuNCs still face the challenge of insufficient reactive oxygen species (ROS) production limited near‐infrared light absorption. This study develops model indocyanine green (ICG)‐sensitized atomic‐precision size effect. approach achieved absorption while inhibiting radiation transitions, thereby regulating generation ROS. Notably, different‐sized (Au 10 NCs, Au 15 25 NCs) yielded varied ROS types, resulting from different energy level distributions electron transfer rates. ICG‐Au NCs treatment efficacy 99.94% against Staphylococcus aureus in vitro significantly accelerated wound healing vivo. Moreover, this highlights unique role ICG‐AuNCs suppressing quorum sensing, virulence, ABC transporters compared larger counterparts. strategy demonstrates effect paves way for innovative approaches infection control.
Язык: Английский
Процитировано
2