Gelatin-based composite film integrated with nanocellulose and extract-metal complex derived from coffee leaf for sustainable and active food packaging

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 159, P. 110610 - 110610

Published: Sept. 6, 2024

Language: Английский

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Acid‐Responsive Bacteria‐Targeted Zinc‐Porphyrin Based Sonosensitizer with Enhancing Antibacterial Efficacy and Biofilm Eradication for Infected Wounds Healing

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract Diseases caused by bacterial infections place a significant burden on global public health. Sonodynamic therapy (SDT), as an emerging antibacterial treatment, faces clinical challenges due to the non‐polar nature of most sonosensitizers. To address this, acid‐responsive zinc‐porphyrin‐based sonosensitizer (Zn‐TCPP) is developed via simple thermal reaction, which then coated with phenylboronic acid‐modified hyaluronic acid (B‐HA), fabricate B‐HA@Zn‐TCPP. While in mildly acidic microenvironment mimicking infected wound site, released B‐HA@Zn‐TCPP achieves effective SDT activity. The disruption membrane and levels intracellular reactive oxygen species (ROS) verified that inhibition rate can reach 99% within 5 min, without any development resistance after 15 consecutive generations culture. Additionally, under ultrasound (US) ‐mediated cavitation, exhibits excellent penetration into biofilms, achieving 90.04% bactericidal for bacteria biofilms. In vivo studies further demonstrated effectively accelerate healing wounds 98.65% 9 days. Therefore, novel offers viable strategy overcome limitations traditional sonosensitizers infections.

Language: Английский

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Advanced biomaterials for targeting mature biofilms in periodontitis therapy

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 474 - 492

Published: Feb. 27, 2025

Language: Английский

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Design and application of antimicrobial nanomaterials in the treatment of periodontitis

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: March 5, 2025

Periodontitis is a chronic inflammatory disease induced by the microbiome, leading to destruction of periodontal structures and potentially resulting in tooth loss. Using local drug delivery systems as an adjunctive therapy scaling root planning periodontitis promising strategy. However, this administration method's effectiveness constrained complexity environment. Nanomaterials have demonstrated significant potential antibacterial treatment periodontitis, attributed their controllable size, shape, surface charge, high design flexibility, reactivity, specific area. In review, we summarize complex microenvironment difficulties explicitly reviewing application strategies nanomaterials with unique properties distinct periodontitis. Furthermore, review discusses limitations current research, proposes feasible solutions, explores prospects for using context.

Language: Английский

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Mild photothermal-driven nanorobots for infected wound healing through effective photodynamic therapy and wound microenvironment remodeling

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162255 - 162255

Published: April 1, 2025

Language: Английский

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Hesperidin-loaded self-assembled supramolecular hydrogel based on quaternized chitosan as efficient photothermal antibacterial dressing for MRSA-infected wound healing

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123577 - 123577

Published: April 1, 2025

Language: Английский

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Response Surface Methodology for Ni-Zeolite Catalyst Optimization in Syngas Production

ACS Omega, Journal Year: 2024, Volume and Issue: 9(40), P. 41636 - 41650

Published: Sept. 25, 2024

This work addresses the problem of converting waste methane, a significant greenhouse gas, using customized nickel-zeolite catalysts to produce profitable syngas. The investigation employs 5 wt % Ni on various zeolite supports with Si/Al ratios ranging from 13 25. Comprehensive characterization methods, including temperature-programmed reduction, N

Language: Английский

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Iron‐MOFs for Biomedical Applications

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Over the past two decades, iron-based metal-organic frameworks (Fe-MOFs) have attracted significant research interest in biomedicine due to their low toxicity, tunable degradability, substantial drug loading capacity, versatile structures, and multimodal functionalities. Despite great potential, transition of Fe-MOFs-based composites from laboratory clinical products remains challenging. This review evaluates key properties that distinguish Fe-MOFs other MOFs highlights recent advances synthesis routes, surface engineering, shaping technologies. In particular, it focuses on applications biosensing, antimicrobial, anticancer therapies. addition, emphasizes need develop scalable, environmentally friendly, cost-effective production methods for additional meet specific requirements various biomedical applications. ability combine therapies, hurdles still remain, including a deeper understanding therapeutic mechanisms potential risks resistance overdose. Systematically addressing these challenges could significantly enhance prospects potentially facilitate integration into mainstream practice.

Language: Английский

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A multifunctional biosensor for selective identification, sensitive detection and efficient photothermal sterilization of Salmonella typhimurium and Staphylococcus aureus

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1338, P. 343589 - 343589

Published: Dec. 25, 2024

Language: Английский

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Enhancing antibacterial photodynamic therapy with NIR‐activated gold nanoclusters: Atomic‐precision size effect on reducing bacterial biofilm formation and virulence

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Abstract Persistent biofilm infections pose a critical health threat with their relentless presence and amplified antibiotic resistance. Traditional antibacterial photodynamic therapy can inhibit bacteria extracellularly but struggles to control formation virulence. Thus, there is an urgent need develop photosensitizers, such as ultra‐small gold nanoclusters (AuNCs), that penetrate biofilms internalize into bacteria. However, AuNCs still face the challenge of insufficient reactive oxygen species (ROS) production limited near‐infrared light absorption. This study develops model indocyanine green (ICG)‐sensitized atomic‐precision size effect. approach achieved absorption while inhibiting radiation transitions, thereby regulating generation ROS. Notably, different‐sized (Au 10 NCs, Au 15 25 NCs) yielded varied ROS types, resulting from different energy level distributions electron transfer rates. ICG‐Au NCs treatment efficacy 99.94% against Staphylococcus aureus in vitro significantly accelerated wound healing vivo. Moreover, this highlights unique role ICG‐AuNCs suppressing quorum sensing, virulence, ABC transporters compared larger counterparts. strategy demonstrates effect paves way for innovative approaches infection control.

Language: Английский

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