Evaluation of indocyanine green antimicrobial photodynamic therapy in radical species elimination: an in vitro study DOI Creative Commons
Mihail Z Tanev, Georgi Tomov, Kostadin G Georgiev

et al.

Folia Medica, Journal Year: 2024, Volume and Issue: 66(6), P. 876 - 883

Published: Dec. 31, 2024

Introduction : Antimicrobial photodynamic therapy (aPDT) utilizes light-sensitive materials to inactivate pathogens. Indocyanine green (ICG) is an FDA-approved photosensitizer known for its effective photo-thermal and photo-chemical properties. Aim This study evaluates the efficacy of ICG-based aPDT in eliminating reactive species compared methylene blue (MtB) using electron paramagnetic resonance (EPR) spectroscopy. Materials methods Solid samples ICG MtB were prepared at 0.33% concentrations. Solutions irradiated with lasers 810 nm 630 nm, respectively. EPR spectroscopy measured oxygen (ROS) nitrogen (RNS). Spin-trapping agents assessed alkyl radicals, superoxide, singlet oxygen. Results demonstrated higher scavenging activity ROS/RNS MtB. Under PDT, significantly enhanced reduction photooxidative stress markers vitro. Conclusions combined more than reducing ROS/RNS, indicating potential antimicrobial applications.

Language: Английский

Gelatin-based composite film integrated with nanocellulose and extract-metal complex derived from coffee leaf for sustainable and active food packaging DOI

Fangfei Sun,

Juan Zhao, Shan Peng

et al.

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 159, P. 110610 - 110610

Published: Sept. 6, 2024

Language: Английский

Citations

8

Acid‐Responsive Bacteria‐Targeted Zinc‐Porphyrin Based Sonosensitizer with Enhancing Antibacterial Efficacy and Biofilm Eradication for Infected Wounds Healing DOI Open Access

Xingjun Zhao,

Jiaxin Li, Peng Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract Diseases caused by bacterial infections place a significant burden on global public health. Sonodynamic therapy (SDT), as an emerging antibacterial treatment, faces clinical challenges due to the non‐polar nature of most sonosensitizers. To address this, acid‐responsive zinc‐porphyrin‐based sonosensitizer (Zn‐TCPP) is developed via simple thermal reaction, which then coated with phenylboronic acid‐modified hyaluronic acid (B‐HA), fabricate B‐HA@Zn‐TCPP. While in mildly acidic microenvironment mimicking infected wound site, released B‐HA@Zn‐TCPP achieves effective SDT activity. The disruption membrane and levels intracellular reactive oxygen species (ROS) verified that inhibition rate can reach 99% within 5 min, without any development resistance after 15 consecutive generations culture. Additionally, under ultrasound (US) ‐mediated cavitation, exhibits excellent penetration into biofilms, achieving 90.04% bactericidal for bacteria biofilms. In vivo studies further demonstrated effectively accelerate healing wounds 98.65% 9 days. Therefore, novel offers viable strategy overcome limitations traditional sonosensitizers infections.

Language: Английский

Citations

0

Advanced biomaterials for targeting mature biofilms in periodontitis therapy DOI
Jie Tao,

Yirong Sun,

Guoliang Wang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 474 - 492

Published: Feb. 27, 2025

Language: Английский

Citations

0

Design and application of antimicrobial nanomaterials in the treatment of periodontitis DOI
Chunlin Wang,

Yujun Yang,

Ning Wang

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: March 5, 2025

Periodontitis is a chronic inflammatory disease induced by the microbiome, leading to destruction of periodontal structures and potentially resulting in tooth loss. Using local drug delivery systems as an adjunctive therapy scaling root planning periodontitis promising strategy. However, this administration method's effectiveness constrained complexity environment. Nanomaterials have demonstrated significant potential antibacterial treatment periodontitis, attributed their controllable size, shape, surface charge, high design flexibility, reactivity, specific area. In review, we summarize complex microenvironment difficulties explicitly reviewing application strategies nanomaterials with unique properties distinct periodontitis. Furthermore, review discusses limitations current research, proposes feasible solutions, explores prospects for using context.

Language: Английский

Citations

0

Mild photothermal-driven nanorobots for infected wound healing through effective photodynamic therapy and wound microenvironment remodeling DOI Creative Commons
Xiaomeng Hao, Jinmei Wu, Ming Luo

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162255 - 162255

Published: April 1, 2025

Language: Английский

Citations

0

Hesperidin-loaded self-assembled supramolecular hydrogel based on quaternized chitosan as efficient photothermal antibacterial dressing for MRSA-infected wound healing DOI
Yamin Xiong, Yi Hao,

Linlin Ding

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123577 - 123577

Published: April 1, 2025

Language: Английский

Citations

0

Multifunctional nanocomposite-driven microneedles enabling bacteria capturing, detecting, and killing for precision treatment of acne with varying severities DOI
Huaan Li, Hanqi Li,

Yuwei Kou

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163339 - 163339

Published: May 1, 2025

Language: Английский

Citations

0

Response Surface Methodology for Ni-Zeolite Catalyst Optimization in Syngas Production DOI Creative Commons
Yousef Mohammed Alanazi, Ahmed S. Al‐Fatesh, Fahad S. Al‐Mubaddel

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(40), P. 41636 - 41650

Published: Sept. 25, 2024

This work addresses the problem of converting waste methane, a significant greenhouse gas, using customized nickel-zeolite catalysts to produce profitable syngas. The investigation employs 5 wt % Ni on various zeolite supports with Si/Al ratios ranging from 13 25. Comprehensive characterization methods, including temperature-programmed reduction, N

Language: Английский

Citations

3

Iron‐MOFs for Biomedical Applications DOI Creative Commons
Zhihao Yu, Mathilde Lepoitevin, Christian Serre

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Over the past two decades, iron-based metal-organic frameworks (Fe-MOFs) have attracted significant research interest in biomedicine due to their low toxicity, tunable degradability, substantial drug loading capacity, versatile structures, and multimodal functionalities. Despite great potential, transition of Fe-MOFs-based composites from laboratory clinical products remains challenging. This review evaluates key properties that distinguish Fe-MOFs other MOFs highlights recent advances synthesis routes, surface engineering, shaping technologies. In particular, it focuses on applications biosensing, antimicrobial, anticancer therapies. addition, emphasizes need develop scalable, environmentally friendly, cost-effective production methods for additional meet specific requirements various biomedical applications. ability combine therapies, hurdles still remain, including a deeper understanding therapeutic mechanisms potential risks resistance overdose. Systematically addressing these challenges could significantly enhance prospects potentially facilitate integration into mainstream practice.

Language: Английский

Citations

3

A multifunctional biosensor for selective identification, sensitive detection and efficient photothermal sterilization of Salmonella typhimurium and Staphylococcus aureus DOI

Huasong Dai,

Yingyue Zhang,

Wenshi Zhao

et al.

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1338, P. 343589 - 343589

Published: Dec. 25, 2024

Language: Английский

Citations

3