Folia Medica,
Journal Year:
2024,
Volume and Issue:
66(6), P. 876 - 883
Published: Dec. 31, 2024
Introduction
:
Antimicrobial
photodynamic
therapy
(aPDT)
utilizes
light-sensitive
materials
to
inactivate
pathogens.
Indocyanine
green
(ICG)
is
an
FDA-approved
photosensitizer
known
for
its
effective
photo-thermal
and
photo-chemical
properties.
Aim
This
study
evaluates
the
efficacy
of
ICG-based
aPDT
in
eliminating
reactive
species
compared
methylene
blue
(MtB)
using
electron
paramagnetic
resonance
(EPR)
spectroscopy.
Materials
methods
Solid
samples
ICG
MtB
were
prepared
at
0.33%
concentrations.
Solutions
irradiated
with
lasers
810
nm
630
nm,
respectively.
EPR
spectroscopy
measured
oxygen
(ROS)
nitrogen
(RNS).
Spin-trapping
agents
assessed
alkyl
radicals,
superoxide,
singlet
oxygen.
Results
demonstrated
higher
scavenging
activity
ROS/RNS
MtB.
Under
PDT,
significantly
enhanced
reduction
photooxidative
stress
markers
vitro.
Conclusions
combined
more
than
reducing
ROS/RNS,
indicating
potential
antimicrobial
applications.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 10, 2025
Abstract
Diseases
caused
by
bacterial
infections
place
a
significant
burden
on
global
public
health.
Sonodynamic
therapy
(SDT),
as
an
emerging
antibacterial
treatment,
faces
clinical
challenges
due
to
the
non‐polar
nature
of
most
sonosensitizers.
To
address
this,
acid‐responsive
zinc‐porphyrin‐based
sonosensitizer
(Zn‐TCPP)
is
developed
via
simple
thermal
reaction,
which
then
coated
with
phenylboronic
acid‐modified
hyaluronic
acid
(B‐HA),
fabricate
B‐HA@Zn‐TCPP.
While
in
mildly
acidic
microenvironment
mimicking
infected
wound
site,
released
B‐HA@Zn‐TCPP
achieves
effective
SDT
activity.
The
disruption
membrane
and
levels
intracellular
reactive
oxygen
species
(ROS)
verified
that
inhibition
rate
can
reach
99%
within
5
min,
without
any
development
resistance
after
15
consecutive
generations
culture.
Additionally,
under
ultrasound
(US)
‐mediated
cavitation,
exhibits
excellent
penetration
into
biofilms,
achieving
90.04%
bactericidal
for
bacteria
biofilms.
In
vivo
studies
further
demonstrated
effectively
accelerate
healing
wounds
98.65%
9
days.
Therefore,
novel
offers
viable
strategy
overcome
limitations
traditional
sonosensitizers
infections.
Nanomedicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 17
Published: March 5, 2025
Periodontitis
is
a
chronic
inflammatory
disease
induced
by
the
microbiome,
leading
to
destruction
of
periodontal
structures
and
potentially
resulting
in
tooth
loss.
Using
local
drug
delivery
systems
as
an
adjunctive
therapy
scaling
root
planning
periodontitis
promising
strategy.
However,
this
administration
method's
effectiveness
constrained
complexity
environment.
Nanomaterials
have
demonstrated
significant
potential
antibacterial
treatment
periodontitis,
attributed
their
controllable
size,
shape,
surface
charge,
high
design
flexibility,
reactivity,
specific
area.
In
review,
we
summarize
complex
microenvironment
difficulties
explicitly
reviewing
application
strategies
nanomaterials
with
unique
properties
distinct
periodontitis.
Furthermore,
review
discusses
limitations
current
research,
proposes
feasible
solutions,
explores
prospects
for
using
context.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(40), P. 41636 - 41650
Published: Sept. 25, 2024
This
work
addresses
the
problem
of
converting
waste
methane,
a
significant
greenhouse
gas,
using
customized
nickel-zeolite
catalysts
to
produce
profitable
syngas.
The
investigation
employs
5
wt
%
Ni
on
various
zeolite
supports
with
Si/Al
ratios
ranging
from
13
25.
Comprehensive
characterization
methods,
including
temperature-programmed
reduction,
N
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Over
the
past
two
decades,
iron-based
metal-organic
frameworks
(Fe-MOFs)
have
attracted
significant
research
interest
in
biomedicine
due
to
their
low
toxicity,
tunable
degradability,
substantial
drug
loading
capacity,
versatile
structures,
and
multimodal
functionalities.
Despite
great
potential,
transition
of
Fe-MOFs-based
composites
from
laboratory
clinical
products
remains
challenging.
This
review
evaluates
key
properties
that
distinguish
Fe-MOFs
other
MOFs
highlights
recent
advances
synthesis
routes,
surface
engineering,
shaping
technologies.
In
particular,
it
focuses
on
applications
biosensing,
antimicrobial,
anticancer
therapies.
addition,
emphasizes
need
develop
scalable,
environmentally
friendly,
cost-effective
production
methods
for
additional
meet
specific
requirements
various
biomedical
applications.
ability
combine
therapies,
hurdles
still
remain,
including
a
deeper
understanding
therapeutic
mechanisms
potential
risks
resistance
overdose.
Systematically
addressing
these
challenges
could
significantly
enhance
prospects
potentially
facilitate
integration
into
mainstream
practice.
