Proteobacteria: microbial signature of dysbiosis in gut microbiota

Trends in biotechnology, Год журнала: 2015, Номер 33(9), С. 496 - 503

Опубликована: Июль 22, 2015

Язык: Английский

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The Human Intestinal Microbiome in Health and Disease

New England Journal of Medicine, Год журнала: 2016, Номер 375(24), С. 2369 - 2379

Опубликована: Дек. 14, 2016

The large majority of studies on the role microbiome in pathogenesis disease are correlative and preclinical; several have influenced clinical practice.

Язык: Английский

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Human Genetics Shape the Gut Microbiome

Cell, Год журнала: 2014, Номер 159(4), С. 789 - 799

Опубликована: Ноя. 1, 2014

Язык: Английский

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The gut microbiota influences blood-brain barrier permeability in mice

Science Translational Medicine, Год журнала: 2014, Номер 6(263)

Опубликована: Ноя. 19, 2014

The intestinal microbiota helps to maintain the integrity of blood-brain barrier in fetal and adult mice.

Язык: Английский

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Diet–microbiota interactions as moderators of human metabolism

Nature, Год журнала: 2016, Номер 535(7610), С. 56 - 64

Опубликована: Июль 5, 2016

Язык: Английский

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Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

Science, Год журнала: 2013, Номер 339(6123), С. 1084 - 1088

Опубликована: Янв. 18, 2013

Microbial exposures and sex hormones exert potent effects on autoimmune diseases, many of which are more prevalent in women. We demonstrate that early-life microbial determine hormone levels modify progression to autoimmunity the nonobese diabetic (NOD) mouse model type 1 diabetes (T1D). Colonization by commensal microbes elevated serum testosterone protected NOD males from T1D. Transfer gut microbiota adult immature females altered recipient's microbiota, resulting metabolomic changes, reduced islet inflammation autoantibody production, robust T1D protection. These were dependent androgen receptor activity. Thus, community alters regulates disease fate individuals with high genetic risk.

Язык: Английский

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Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

Molecular Psychiatry, Год журнала: 2016, Номер 21(6), С. 786 - 796

Опубликована: Апрель 12, 2016

Язык: Английский

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MicrobiomeAnalyst: a web-based tool for comprehensive statistical, visual and meta-analysis of microbiome data

Nucleic Acids Research, Год журнала: 2017, Номер 45(W1), С. W180 - W188

Опубликована: Апрель 12, 2017

The widespread application of next-generation sequencing technologies has revolutionized microbiome research by enabling high-throughput profiling the genetic contents microbial communities. How to analyze resulting large complex datasets remains a key challenge in current studies. Over past decade, powerful computational pipelines and robust protocols have been established enable efficient raw data processing annotation. focus shifted toward downstream statistical analysis functional interpretation. Here, we introduce MicrobiomeAnalyst, user-friendly tool that integrates recent progress statistics visualization techniques, coupled with novel knowledge bases, comprehensive common outputs produced from MicrobiomeAnalyst contains four modules - Marker Data Profiling module offers various options for community profiling, comparative prediction based on 16S rRNA marker gene data; Shotgun supports exploratory analysis, metabolic network shotgun metagenomics or metatranscriptomics Taxon Set Enrichment Analysis helps interpret taxonomic signatures via enrichment against >300 taxon sets manually curated literature public databases; finally, Projection Public allows users visually explore their reference pattern discovery biological insights. is freely available at http://www.microbiomeanalyst.ca.

Язык: Английский

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Microbiota in health and diseases

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Апрель 23, 2022

Abstract The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery. Depending on the localized regions, can be classified into gut, oral, respiratory, skin microbiota. microbial communities are symbiosis with host, contributing to homeostasis regulating immune function. However, dysbiosis lead dysregulation bodily functions including cardiovascular (CVDs), cancers, respiratory diseases, etc. In this review, we discuss current knowledge how links host or pathogenesis. We first summarize research healthy conditions, gut-brain axis, colonization resistance modulation. Then, highlight pathogenesis disease development progression, primarily associated community composition, modulation response, induction chronic inflammation. Finally, introduce clinical approaches that utilize for treatment, such as fecal transplantation.

Язык: Английский

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Dysbiosis and the immune system

Nature reviews. Immunology, Год журнала: 2017, Номер 17(4), С. 219 - 232

Опубликована: Март 6, 2017

Язык: Английский

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