Chemical transformation of xenobiotics by the human gut microbiota

Science, Год журнала: 2017, Номер 356(6344)

Опубликована: Июнь 23, 2017

The human gut microbiota makes key contributions to the metabolism of ingested compounds (xenobiotics), transforming hundreds dietary components, industrial chemicals, and pharmaceuticals into metabolites with altered activities, toxicities, lifetimes within body. chemistry microbial xenobiotic is often distinct from that host enzymes. Despite their important consequences for biology, microbes, genes, enzymes involved in are poorly understood. Linking these transformations elucidating biological effects undoubtedly challenging. However, recent studies demonstrate integrating traditional emerging technologies can enable progress toward this goal. Ultimately, a molecular understanding will guide personalized medicine nutrition, inform toxicology risk assessment, improve drug discovery development.

Язык: Английский

---

Butyrate: A Double-Edged Sword for Health?

Advances in Nutrition, Год журнала: 2018, Номер 9(1), С. 21 - 29

Опубликована: Янв. 1, 2018

Язык: Английский

---

The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome

Nutrients, Год журнала: 2020, Номер 12(4), С. 1107 - 1107

Опубликована: Апрель 16, 2020

The relationship between diet and the diversity function of intestinal microbiome its importance for human health is currently subject many studies. type proportion microorganisms found in intestines can determine energy balance host. Intestinal perform important functions, one which participation metabolic processes, e.g., production short-chain fatty acids—SCFAs (also called volatile acids). These acids represent main carbon flow from to host microbiome. Maintaining necessary maintain host's normal prevent diseases. results studies confirm beneficial effect probiotic on produced metabolites, including SCFAs. aim this review summarize what known effects probiotics by gut microbes. In addition, mechanism formation properties these metabolites discussed verified test confirming effectiveness nutrition modulating SCFAs presented.

Язык: Английский

---

Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

Journal of Gastroenterology, Год журнала: 2016, Номер 52(1), С. 1 - 8

Опубликована: Июль 23, 2016

Язык: Английский

---

The intestinal microbiota fuelling metabolic inflammation

Nature reviews. Immunology, Год журнала: 2019, Номер 20(1), С. 40 - 54

Опубликована: Авг. 6, 2019

Язык: Английский

---