Visual
systems
can
exploit
spatial
correlations
in
the
visual
scene
by
using
retinotopy,
organizing
principle
which
neighboring
cells
encode
locations.
However,
retinotopy
is
often
lost,
such
as
when
pathways
are
integrated
with
other
sensory
modalities.
How
information
processed
outside
of
strictly
brain
areas?
Here,
we
focused
on
looming
responsive
LC6
Drosophila,
a
population
whose
dendrites
collectively
cover
field,
but
axons
form
single
glomerulus-a
structure
without
obvious
retinotopic
organization-in
central
brain.
We
identified
multiple
cell
types
downstream
glomerulus
and
found
that
they
more
strongly
respond
to
different
portions
unexpectedly
preserving
information.
Through
EM
reconstruction
all
synaptic
inputs
glomerulus,
circuits
within
enable
readout
features
contralateral
suppression-mechanisms
transform
for
behavioral
control.
Flexible
behaviors
over
long
timescales
are
thought
to
engage
recurrent
neural
networks
in
deep
brain
regions,
which
experimentally
challenging
study.
In
insects,
circuit
dynamics
a
region
called
the
central
complex
(CX)
enable
directed
locomotion,
sleep,
and
context-
experience-dependent
spatial
navigation.
We
describe
first
complete
electron
microscopy-based
connectome
of
Neuron,
Год журнала:
2022,
Номер
110(10), С. 1700 - 1711.e6
Опубликована: Март 14, 2022
Topographic
maps,
the
systematic
spatial
ordering
of
neurons
by
response
tuning,
are
common
across
species.
In
Drosophila,
lobula
columnar
(LC)
neuron
types
project
from
optic
lobe
to
central
brain,
where
each
forms
a
glomerulus
in
distinct
position.
However,
advantages
this
glomerular
arrangement
unclear.
Here,
we
examine
functional
and
relationships
10
glomeruli
using
single-neuron
calcium
imaging.
We
discover
novel
detectors
for
objects
smaller
than
lens
resolution
(LC18)
complex
line
motion
(LC25).
find
that
spatially
clustered
selectivity
looming
versus
drifting
object
ordered
size
tuning
form
topographic
visual
feature
map.
Furthermore,
connectome
analysis
shows
downstream
integrate
sparse
subsets
possible
combinations,
which
biased
encoding
similar
features.
LC
thus
an
explicit
example
topographically
organized
facilitate
circuit
integration.
Current Biology,
Год журнала:
2024,
Номер
34(4), С. 808 - 824.e6
Опубликована: Янв. 30, 2024
Many
motor
control
systems
generate
multiple
movements
using
a
common
set
of
muscles.
How
are
premotor
circuits
able
to
flexibly
diverse
movement
patterns?
Here,
we
characterize
the
neuronal
that
drive
distinct
courtship
songs
Drosophila
melanogaster.
Male
flies
vibrate
their
wings
toward
females
produce
two
different
song
modes—pulse
and
sine
song—which
signal
species
identity
male
quality.
Using
cell-type-specific
genetic
reagents
connectome,
provide
cellular
synaptic
map
in
ventral
nerve
cord
these
examine
how
activating
or
inhibiting
each
cell
type
within
affects
song.
Our
data
reveal
circuit
is
organized
into
nested
feedforward
pathways
with
extensive
reciprocal
feedback
connections.
The
larger
network
produces
pulse
song,
more
complex
ancestral
form.
A
subset
this
simpler
recent
Such
organization
may
be
feature
which
evolution
has
layered
increasing
flexibility
onto
basic
pattern.
Aggressive
social
interactions
are
used
to
compete
for
limited
resources
and
regulated
by
complex
sensory
cues
the
organism's
internal
state.
While
both
sexes
exhibit
aggression,
its
neuronal
underpinnings
understudied
in
females.
Here,
we
identify
a
population
of
sexually
dimorphic
aIPg
neurons
adult
Drosophila
melanogaster
central
brain
whose
optogenetic
activation
increased,
genetic
inactivation
reduced,
female
aggression.
Analysis
GAL4
lines
identified
an
unbiased
screen
increased
chasing
behavior
revealed
involvement
another
neuron,
pC1d,
implicated
pC1d
as
core
nodes
regulating
Connectomic
analysis
demonstrated
that
interconnected
suggest
may
exert
part
their
effect
gating
flow
visual
information
descending
neurons.
Our
work
reveals
important
regulatory
components
circuitry
underlies
aggressive
provides
tools
manipulation.
