Maximally efficient prediction in the early fly visual system may support evasive flight maneuvers DOI Creative Commons
Siwei Wang, Idan Segev, Alexander Borst

и другие.

PLoS Computational Biology, Год журнала: 2021, Номер 17(5), С. e1008965 - e1008965

Опубликована: Май 20, 2021

The visual system must make predictions to compensate for inherent delays in its processing. Yet little is known, mechanistically, about how prediction aids natural behaviors. Here, we show that despite a 20-30ms intrinsic processing delay, the vertical motion sensitive (VS) network of blowfly achieves maximally efficient prediction. This enables fly fine-tune complex, yet brief, evasive flight maneuvers according initial ego-rotation at time detection threat. Combining rich database behavioral recordings with detailed compartmental modeling VS network, further has axonal gap junctions are critical optimal During maneuvers, subpopulation directly innervates neck motor center can convey predictive information fly’s future ego-rotation, potentially crucial ongoing control. These results suggest novel sensory-motor pathway links sensory behavior.

Язык: Английский

A connectome and analysis of the adult Drosophila central brain DOI Creative Commons
Louis K. Scheffer, C. Shan Xu, Michał Januszewski

и другие.

eLife, Год журнала: 2020, Номер 9

Опубликована: Сен. 3, 2020

The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction brain fruit fly Drosophila melanogaster . Improved include procedures to prepare, image, align, segment, find synapses in, proofread such data sets. define cell types, refine computational compartments, provide an exhaustive atlas examples many them novel. detailed consisting neurons their chemical most central brain. make public simplify access, reducing effort needed answer circuit questions, linking defined by our analysis with genetic reagents. Biologically, we examine distributions connection strengths, motifs on different scales, electrical consequences compartmentalization, evidence that maximizing packing density is important criterion in evolution fly’s

Язык: Английский

Процитировано

978
A functionally ordered visual feature map in the Drosophila brain DOI Creative Commons
Nathan C Klapoetke, Aljoscha Nern, Edward M. Rogers

и другие.

Neuron, Год журнала: 2022, Номер 110(10), С. 1700 - 1711.e6

Опубликована: Март 14, 2022

Topographic maps, the systematic spatial ordering of neurons by response tuning, are common across species. In Drosophila, lobula columnar (LC) neuron types project from optic lobe to central brain, where each forms a glomerulus in distinct position. However, advantages this glomerular arrangement unclear. Here, we examine functional and relationships 10 glomeruli using single-neuron calcium imaging. We discover novel detectors for objects smaller than lens resolution (LC18) complex line motion (LC25). find that spatially clustered selectivity looming versus drifting object ordered size tuning form topographic visual feature map. Furthermore, connectome analysis shows downstream integrate sparse subsets possible combinations, which biased encoding similar features. LC thus an explicit example topographically organized facilitate circuit integration.

Язык: Английский

Процитировано

77
Generating parallel representations of position and identity in the olfactory system DOI Creative Commons
István Taisz, Erika Donà, Daniel Münch

и другие.

Cell, Год журнала: 2023, Номер 186(12), С. 2556 - 2573.e22

Опубликована: Май 25, 2023

In Drosophila, a dedicated olfactory channel senses male pheromone, cis-vaccenyl acetate (cVA), promoting female courtship while repelling males. Here, we show that separate cVA-processing streams extract qualitative and positional information. cVA sensory neurons respond to concentration differences in 5-mm range around male. Second-order projection encode the angular position of by detecting inter-antennal concentration, which are amplified through contralateral inhibition. At third circuit layer, identify 47 cell types with diverse input-output connectivity. One population responds tonically flies, second is tuned looming, integrates taste coincidentally promote mating. The separation features resembles mammalian what where visual streams; together multisensory integration, this enables behavioral responses appropriate specific ethological contexts.

Язык: Английский

Процитировано

43
State-dependent decoupling of sensory and motor circuits underlies behavioral flexibility in Drosophila DOI
Jan M. Ache, Shigehiro Namiki, Allen S. Lee

и другие.

Nature Neuroscience, Год журнала: 2019, Номер 22(7), С. 1132 - 1139

Опубликована: Июнь 10, 2019

Язык: Английский

Процитировано

98
OFF-transient alpha RGCs mediate looming triggered innate defensive response DOI Creative Commons
Fei Wang, Elizabeth Li,

Lei De

и другие.

Current Biology, Год журнала: 2021, Номер 31(11), С. 2263 - 2273.e3

Опубликована: Апрель 2, 2021

Язык: Английский

Процитировано

57
Neuronal circuits integrating visual motion information in Drosophila melanogaster DOI Creative Commons
Kazunori Shinomiya, Aljoscha Nern, Ian A. Meinertzhagen

и другие.

Current Biology, Год журнала: 2022, Номер 32(16), С. 3529 - 3544.e2

Опубликована: Июль 14, 2022

The detection of visual motion enables sophisticated animal navigation, and studies on flies have provided profound insights into the cellular circuit bases this neural computation. fly's directionally selective T4 T5 neurons encode ON OFF motion, respectively. Their axons terminate in one four retinotopic layers lobula plate, where each layer encodes directions motion. Although input circuitry has been studied detail, synaptic connectivity circuits integrating T4/T5 signals is largely unknown. Here, we report a 3D electron microscopy reconstruction, wherein comprehensively identified T4/T5's partners revealing diverse set new cell types attributing patterns to known types. Our reconstruction explains how ON- OFF-motion pathways converge. cells that project same connect common comprise core motif together with bilayer interneurons, detailing basis for computing opponency. We discovered likely by vertical horizontal from upstream neurons. Finally, identify substantial projections lobula, extending suggesting shape feature there. describe enrich anatomical experimental computations analyses vision bring us closer understanding complete sensory-motor pathways.

Язык: Английский

Процитировано

55
Neural Circuits Underlying Behavioral Flexibility: Insights From Drosophila DOI Creative Commons
Anita V. Devineni, Kristin M. Scaplen

Frontiers in Behavioral Neuroscience, Год журнала: 2022, Номер 15

Опубликована: Янв. 6, 2022

Behavioral flexibility is critical to survival. Animals must adapt their behavioral responses based on changes in the environmental context, internal state, or experience. Studies Drosophila melanogaster have provided insight into neural circuit mechanisms underlying flexibility. Here we discuss how behavior modulated by and learning. We describe general principles of organization modulation that underlie flexibility, are likely extend other species.

Язык: Английский

Процитировано

41
Synaptic gradients transform object location to action DOI Creative Commons
Mark Dombrovski,

Martin Y. Peek,

Jin-Yong Park

и другие.

Nature, Год журнала: 2023, Номер 613(7944), С. 534 - 542

Опубликована: Янв. 4, 2023

Abstract To survive, animals must convert sensory information into appropriate behaviours 1,2 . Vision is a common sense for locating ethologically relevant stimuli and guiding motor responses 3–5 How circuitry converts object location in retinal coordinates to movement direction body remains largely unknown. Here we show through behaviour, physiology, anatomy connectomics Drosophila that visuomotor transformation occurs by conversion of topographic maps formed the dendrites feature-detecting visual projection neurons (VPNs) 6,7 synaptic weight gradients VPN outputs onto central brain neurons. We demonstrate how this gradient motif transforms anteroposterior looming stimulus fly’s directional escape. Specifically, discover two postsynaptic looming-responsive type promote opposite takeoff directions. Opposite these from VPNs different field regions localized threats correctly oriented escapes. For second type, graded along dorsoventral axis. generalizes across all 20 primary cell types most often arises without axon topography. Synaptic may thus be general mechanism conveying spatial features directed outputs.

Язык: Английский

Процитировано

36
Visual processing in the fly, from photoreceptors to behavior DOI Creative Commons
Timothy A. Currier, Michelle M. Pang, Thomas R. Clandinin

и другие.

Genetics, Год журнала: 2023, Номер 224(2)

Опубликована: Май 2, 2023

Abstract Originally a genetic model organism, the experimental use of Drosophila melanogaster has grown to include quantitative behavioral analyses, sophisticated perturbations neuronal function, and detailed sensory physiology. A highlight these developments can be seen in context vision, where pioneering studies have uncovered fundamental generalizable principles processing. Here we begin with an overview vision-guided behaviors common methods for probing visual circuits. We then outline anatomy physiology brain regions involved processing, beginning at periphery ending descending motor control. Areas focus contrast motion detection optic lobe, circuits feature selectivity, computations support spatial navigation, contextual associative learning. Finally, look future fly neuroscience discuss promising topics further study.

Язык: Английский

Процитировано

35
Single-cell type analysis of wing premotor circuits in the ventral nerve cord ofDrosophila melanogaster DOI Creative Commons
Erica Ehrhardt, Samuel C. Whitehead, Shigehiro Namiki

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июнь 1, 2023

To perform most behaviors, animals must send commands from higher-order processing centers in the brain to premotor circuits that reside ganglia distinct brain, such as mammalian spinal cord or insect ventral nerve cord. How these are functionally organized generate great diversity of animal behavior remains unclear. An important first step unraveling organization is identify their constituent cell types and create tools monitor manipulate with high specificity assess function. This possible tractable fly. a toolkit, we used combinatorial genetic technique (split-GAL4) 195 sparse driver lines targeting 198 individual These included wing haltere motoneurons, modulatory neurons, interneurons. Using combination behavioral, developmental, anatomical analyses, systematically characterized targeted our collection. Taken together, resources results presented here form powerful toolkit for future investigations neural connectivity while linking them behavioral outputs.

Язык: Английский

Процитировано

24