Cellular & Molecular Biology Letters,
Год журнала:
2024,
Номер
29(1)
Опубликована: Апрель 12, 2024
Abstract
T
cell
immunity
is
central
to
contemporary
cancer
and
autoimmune
therapies,
encompassing
immune
checkpoint
blockade
adoptive
therapies.
Their
diverse
characteristics
can
be
reprogrammed
by
different
challenges
dependent
on
antigen
stimulation
levels,
metabolic
conditions,
the
degree
of
inflammation.
cell-based
therapeutic
strategies
are
gaining
widespread
adoption
in
oncology
treating
inflammatory
conditions.
Emerging
researches
reveal
that
clustered
regularly
interspaced
palindromic
repeats–associated
protein
9
(CRISPR–Cas9)
genome
editing
has
enabled
cells
more
adaptable
specific
microenvironments,
opening
door
advanced
therapies
preclinical
clinical
trials.
CRISPR–Cas9
edit
both
primary
engineered
cells,
including
CAR-T
TCR-T,
vivo
vitro
regulate
differentiation
activation
states.
This
review
first
provides
a
comprehensive
summary
role
its
applications
studies
for
We
also
explore
application
CRISPR
screen
high-throughput
technology
anticipate
current
limitations
CRISPR–Cas9,
off-target
effects
delivery
challenges,
envisioned
improvements
related
technologies
disease
screening,
diagnosis,
treatment.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2022,
Номер
41(1)
Опубликована: Сен. 12, 2022
Abstract
Elesclomol
is
an
anticancer
drug
that
targets
mitochondrial
metabolism.
In
the
past,
elesclomol
was
recognized
as
inducer
of
oxidative
stress,
but
now
it
has
also
been
found
to
suppress
cancer
by
inducing
cuproptosis.
Elesclomol’s
activity
determined
dependence
on
The
metabolism
stem
cells,
cells
resistant
platinum
drugs,
proteasome
inhibitors,
molecularly
targeted
and
with
inhibited
glycolysis
significantly
enhanced.
exhibited
tremendous
toxicity
all
three
kinds
cells.
Elesclomol's
highly
dependent
its
transport
extracellular
copper
ions,
a
process
involved
in
discovery
cuproptosis
perfected
specific
suppressor
mechanism
elesclomol.
For
some
time,
failed
yield
favorable
results
oncology
clinical
trials,
safety
application
confirmed.
Research
progress
relationship
between
elesclomol,
provides
possibility
explore
reapplication
clinic.
New
trials
should
selectively
target
types
high
attempt
combine
platinum,
or
inhibitors.
Herein,
particular
will
be
presented,
which
may
shed
light
better
tumor
treatment.
Experimental Hematology and Oncology,
Год журнала:
2022,
Номер
11(1)
Опубликована: Апрель 23, 2022
During
the
course
of
tumorigenesis
and
subsequent
metastasis,
malignant
cells
gradually
diversify
become
more
heterogeneous.
Consequently,
tumor
mass
might
be
infiltrated
by
diverse
immune-related
components,
including
cytokine/chemokine
environment,
cytotoxic
activity,
or
immunosuppressive
elements.
This
immunological
heterogeneity
is
universally
presented
spatially
varies
temporally
along
with
evolution
therapeutic
intervention
across
almost
all
solid
tumors.
The
anti-tumor
immunity
shows
a
profound
association
progression
disease
responsiveness
to
treatment,
particularly
in
realm
immunotherapy.
Therefore,
an
accurate
understanding
essential
for
development
effective
therapies.
Facilitated
multi-regional
-omics
sequencing,
single
cell
longitudinal
liquid
biopsy
approaches,
recent
studies
have
demonstrated
potential
investigate
complexity
tumors
its
clinical
relevance
Here,
we
aimed
review
mechanism
underlying
immune
microenvironment.
We
also
explored
how
assessments
facilitate
personalized
Endocrine Reviews,
Год журнала:
2022,
Номер
44(1), С. 117 - 141
Опубликована: Июнь 16, 2022
The
immune
system
functions
in
a
sexually
dimorphic
manner,
with
females
exhibiting
more
robust
responses
than
males.
However,
how
female
sex
hormones
affect
function
normal
homeostasis
and
autoimmunity
is
poorly
understood.
In
this
review,
we
discuss
estrogens
innate
adaptive
cell
activity
dysregulation
of
estrogen
signaling
underlies
the
pathobiology
some
autoimmune
diseases
cancers.
potential
roles
major
circulating
estrogens,
each
3
receptors
(ERα,
ERβ,
G-protein
coupled
receptor)
regulation
different
cells
are
considered.
This
provides
framework
for
discussion
impact
ER
modulators
(aromatase
inhibitors,
selective
receptor
modulators,
downregulators)
on
immunity.
Synthesis
information
timely
given
considerable
interest
late
defining
mechanistic
basis
sex-biased
responses/outcomes
patients
cancers
treated
checkpoint
blockade.
It
will
also
be
instructive
respect
to
further
development
that
modulate
immunity
therapeutically
useful
manner.
Acta Pharmaceutica Sinica B,
Год журнала:
2021,
Номер
11(6), С. 1400 - 1411
Опубликована: Фев. 11, 2021
A
major
mitochondrial
enzyme
for
protecting
cells
from
acetaldehyde
toxicity
is
aldehyde
dehydrogenase
2
(ALDH2).
The
correlation
between
ALDH2
dysfunction
and
tumorigenesis/growth/metastasis
has
been
widely
reported.
Either
low
or
high
expression
contributes
to
tumor
progression
varies
among
different
types.
Furthermore,
the
ALDH2∗2
polymorphism
(rs671)
most
common
single
nucleotide
(SNP)
in
Asia.
Epidemiological
studies
associate
with
tumorigenesis
progression.
This
study
summarizes
essential
functions
potential
mechanisms
occurrence,
progression,
treatment
of
tumors
various
types
cancer.
Our
indicates
that
a
therapeutic
target
cancer
therapy.
Briefings in Bioinformatics,
Год журнала:
2022,
Номер
23(2)
Опубликована: Фев. 14, 2022
Abstract
Mass
spectrometry-based
proteomic
technique
has
become
indispensable
in
current
exploration
of
complex
and
dynamic
biological
processes.
Instrument
development
largely
ensured
the
effective
production
data,
which
necessitates
commensurate
advances
statistical
framework
to
discover
optimal
signature.
Current
mainly
emphasizes
generalizability
identified
signature
predicting
independent
data
but
neglects
reproducibility
among
signatures
from
independently
repeated
trials
on
different
sub-dataset.
These
problems
seriously
restricted
wide
application
molecular
biology
other
related
directions.
Thus,
it
is
crucial
enable
generalizable
reproducible
discovery
with
subsequent
indication
phenotype
association.
However,
no
such
tool
been
developed
available
yet.
Herein,
an
online
tool,
POSREG,
was
therefore
constructed
identify
for
a
set
data.
It
works
by
(i)
identifying
good
aggregating
them
ensemble
feature
ranking
learning,
(ii)
assessing
acquire
(iii)
indicating
association
discovered
POSREG
unique
its
capacity
discovering
simultaneously
optimizing
generalizability.
now
accessible
free
charge
without
any
registration
or
login
requirement
at
https://idrblab.org/posreg/
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Фев. 16, 2022
Despite
advances
in
genomic
classification
of
breast
cancer,
current
clinical
tests
and
treatment
decisions
are
commonly
based
on
protein
level
information.
Formalin-fixed
paraffin-embedded
(FFPE)
tissue
specimens
with
extended
outcomes
widely
available.
Here,
we
perform
comprehensive
proteomic
profiling
300
FFPE
cancer
surgical
specimens,
75
each
PAM50
subtype,
from
patients
diagnosed
2008-2013
(n
=
178)
1986-1992
122)
linked
outcomes.
These
two
cohorts
analyzed
separately,
quantify
4214
proteins
across
all
samples.
Within
the
aggressive
PAM50-classified
basal-like
cases,
reveals
groups
one
having
characteristic
immune
hot
expression
features
highly
favorable
survival.
Her2-Enriched
cases
separate
into
heterogeneous
differing
by
extracellular
matrix,
lipid
metabolism,
immune-response
features.
88
triple-negative
cancers,
four
clusters
display
basal-immune
hot,
cold,
mesenchymal,
luminal
disparate
survival
Our
analysis
characterizes
heterogeneity
a
clinically-applicable
manner,
identifies
potential
biomarkers
therapeutic
targets,
provides
resource
for
classification.
Clinical Proteomics,
Год журнала:
2023,
Номер
20(1)
Опубликована: Авг. 26, 2023
Abstract
Mass
spectrometry
(MS)-based
proteomics
have
been
increasingly
implemented
in
various
disciplines
of
laboratory
medicine
to
identify
and
quantify
biomolecules
a
variety
biological
specimens.
MS-based
is
continuously
expanding
widely
applied
biomarker
discovery
for
early
detection,
prognosis
markers
treatment
response
prediction
monitoring.
Furthermore,
making
these
advanced
tests
more
accessible
affordable
will
the
greatest
healthcare
benefit.
This
review
article
highlights
new
paradigms
clinical
has
created
microbiology
laboratories,
cancer
research
diagnosis
metabolic
disorders.
The
technique
preferred
over
conventional
methods
disease
detection
therapy
monitoring
its
combined
advantages
multiplexing
capacity,
remarkable
analytical
specificity
sensitivity
low
turnaround
time.
Despite
achievements
development
adoption
number
practices,
are
expected
undergo
transition
from
bench
bedside
near
future.
provides
insights
trials
recent
progresses
(mainly
covering
literature
NCBI
database)
application
laboratories.
