Mitochondrial signal transduction

Cell Metabolism, Год журнала: 2022, Номер 34(11), С. 1620 - 1653

Опубликована: Ноя. 1, 2022

The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue the processor cell, together with nucleus other they constitute mitochondrial information processing system (MIPS). In a three-step process, (1) sense respond to both endogenous environmental inputs through morphological functional remodeling; (2) integrate network-based physical interactions diffusion mechanisms; (3) produce output signals tune functions systemically regulate physiology. This input-to-output transformation allows metabolic, biochemical, neuroendocrine, local or systemic enhance organismal adaptation. An explicit focus on signal transduction emphasizes role communication in biology. framework also opens new avenues understand how mediate inter-organ processes underlying human health.

Язык: Английский

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The cell biology of ferroptosis

Nature Reviews Molecular Cell Biology, Год журнала: 2024, Номер 25(6), С. 424 - 442

Опубликована: Фев. 16, 2024

Язык: Английский

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Regulation of ferroptosis by lipid metabolism

Trends in Cell Biology, Год журнала: 2023, Номер 33(12), С. 1077 - 1087

Опубликована: Июль 3, 2023

Язык: Английский

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Pore-forming proteins as drivers of membrane permeabilization in cell death pathways

Nature Reviews Molecular Cell Biology, Год журнала: 2022, Номер 24(5), С. 312 - 333

Опубликована: Дек. 21, 2022

Язык: Английский

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Ferroptosis: A flexible constellation of related biochemical mechanisms

Molecular Cell, Год журнала: 2023, Номер 83(7), С. 1030 - 1042

Опубликована: Март 27, 2023

Язык: Английский

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Cell death, therapeutics, and the immune response in cancer

Trends in cancer, Год журнала: 2023, Номер 9(5), С. 381 - 396

Опубликована: Фев. 24, 2023

Язык: Английский

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A guideline on the molecular ecosystem regulating ferroptosis

Nature Cell Biology, Год журнала: 2024, Номер 26(9), С. 1447 - 1457

Опубликована: Фев. 29, 2024

Язык: Английский

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Mitochondria and cell death

Nature Cell Biology, Год журнала: 2024, Номер 26(9), С. 1434 - 1446

Опубликована: Июнь 20, 2024

Язык: Английский

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Ferroptosis in health and disease

Redox Biology, Год журнала: 2024, Номер 75, С. 103211 - 103211

Опубликована: Май 30, 2024

Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark ferroptosis uncontrolled overwhelming peroxidation polyunsaturated fatty acids contained membrane phospholipids, which eventually leads to rupture the plasma membrane. unique that it essentially spontaneous, uncatalyzed chemical process based on perturbed iron redox homeostasis contributing process, but nonetheless modulated by many metabolic nodes impinge cells' susceptibility ferroptosis. Among affecting sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets treatment numerous currently incurable diseases. Herein, current members Germany-wide research consortium focusing research, well key external experts who made seminal contributions this rapidly growing exciting field gathered provide comprehensive, state-of-the-art review Specific topics include: basic mechanisms, vivo relevance, specialized methodologies, tools, potential contribution disease etiopathology progression. We hope article will not only established scientists newcomers with an overview multiple facets ferroptosis, also encourage additional efforts characterize further molecular pathways modulating ultimate goal develop novel pharmacotherapies tackle associated - or caused

Язык: Английский

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Drug-tolerant persister cells in cancer: the cutting edges and future directions

Nature Reviews Clinical Oncology, Год журнала: 2023, Номер 20(11), С. 799 - 813

Опубликована: Сен. 25, 2023

Язык: Английский

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