Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 4, 2025
Background
Gastric
cancer
(GC)
is
a
malignant
tumor
with
poor
prognosis.
The
diverse
patterns
of
programmed
cell
death
(PCD)
are
significantly
associated
the
pathogenesis
and
progression
GC,
it
has
potential
to
serve
as
prognostic
drug
sensitivity
indicators
for
GC.
Method
sequencing
data
clinical
characteristics
GC
patients
were
downloaded
from
Cancer
Genome
Atlas
GEO
databases.
LASSO
cox
regression
method
was
used
screen
feature
genes
develop
PCD
score
(PCDS).
Immune
infiltration,
immune
checkpoint
expression,
Tumor
Dysfunction
Exclusion
(TIDE)
algorithm
analysis
explore
immunotherapy
response.
By
integrating
PCDS
characteristics,
we
constructed
validated
nomogram
that
demonstrated
robust
predictive
performance.
Results
We
screened
nine
PCD-related
(SERPINE1,
PLPPR4,
CDO1,
MID2,
NOX4,
DYNC1I1,
PDK4,
MYB,
TUBB2A)
create
PCDS.
found
high
experienced
poorer
prognoses,
identified
an
independent
factor.
Furthermore,
there
significant
difference
in
profile
between
low
groups.
Additionally,
indicated
may
exhibit
resistance
standard
adjuvant
chemotherapy
regimens;
however,
they
benefit
FDA-approved
Dasatinib.
Conclusion
Overall,
confirmed
risk
factor
valuable
predictor
response
patients,
which
provides
new
evidence
application
Advanced Materials,
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 10, 2023
Rapid
advancements
in
materials
science
and
nanotechnology,
intertwined
with
oncology,
have
positioned
photothermal
therapy
(PTT)
as
a
promising
noninvasive
treatment
strategy
for
cancer.
The
breast's
superficial
anatomical
location
aesthetic
significance
render
breast
cancer
particularly
pertinent
candidate
the
clinical
application
of
PTT
following
melanoma.
This
review
comprehensively
explores
research
conducted
on
various
types
nanoparticles
employed
elaborates
their
specific
roles
mechanisms
action.
integration
existing
therapies
is
scrutinized,
underscoring
its
potential
synergistic
outcomes.
Additionally,
underlying
consequential
modifications
to
tumor
microenvironment
after
are
elaborated
from
medical
perspective.
Future
directions
suggested,
an
emphasis
development
integrative
platforms
that
combine
multiple
therapeutic
approaches
optimization
nanoparticle
synthesis
enhanced
efficacy.
goal
push
boundaries
toward
comprehensive,
clinically
applicable
ACS Nano,
Год журнала:
2023,
Номер
17(20), С. 19581 - 19599
Опубликована: Окт. 11, 2023
Transition
metal
elements,
such
as
copper,
play
diverse
and
pivotal
roles
in
oncology.
They
act
constituents
of
metalloenzymes
involved
cellular
metabolism,
function
signaling
molecules
to
regulate
the
proliferation
metastasis
tumors,
are
integral
components
metal-based
anticancer
drugs.
Notably,
recent
research
reveals
that
excessive
copper
can
also
modulate
occurrence
programmed
cell
death
(PCD),
known
cuprotosis,
cancer
cells.
This
modulation
occurs
through
disruption
tumor
metabolism
induction
proteotoxic
stress.
discovery
uncovers
a
mode
interaction
between
transition
metals
proteins,
emphasizing
intricate
link
homeostasis
metabolism.
Moreover,
they
provide
innovative
therapeutic
strategies
for
precise
diagnosis
treatment
malignant
tumors.
At
crossroads
chemistry
oncology,
we
undertake
comprehensive
review
elucidating
molecular
mechanisms
underpinning
cuproptosis.
Additionally,
summarize
current
nanotherapeutic
approaches
target
cuproptosis
an
overview
available
laboratory
clinical
methods
monitoring
this
process.
In
context
emerging
concepts,
challenges,
opportunities,
emphasize
significant
potential
nanotechnology
advancement
field.
Immunity,
Год журнала:
2023,
Номер
56(10), С. 2270 - 2295
Опубликована: Окт. 1, 2023
Immune
evasion
is
a
hallmark
of
cancer,
enabling
tumors
to
survive
contact
with
the
host
immune
system
and
evade
cycle
recognition
destruction.
Here,
we
review
current
understanding
cancer
cell-intrinsic
factors
driving
evasion.
We
focus
on
T
cells
as
key
effectors
anti-cancer
immunity
argue
that
destruction
by
gaining
control
over
pathways
usually
serve
maintain
physiological
tolerance
self.
Using
this
framework,
place
recent
mechanistic
advances
in
into
broad
categories
cell
localization,
antigen
recognition,
acquisition
optimal
effector
function.
discuss
redundancy
involved
identify
knowledge
gaps
must
be
overcome
better
target
evasion,
including
need
for
better,
routinely
available
tools
incorporate
growing
mechanisms
stratify
patients
therapy
trials.
Phytotherapy Research,
Год журнала:
2024,
Номер
38(8), С. 3954 - 3972
Опубликована: Июнь 4, 2024
Driven
by
iron-dependent
lipid
peroxidation,
ferroptosis
is
regulated
p53
and
solute
carrier
family
7
member
11
(SLC7A11)/glutathione/glutathione
peroxidase
4
(GPX4)
axis
in
colorectal
cancer
(CRC).
This
study
aimed
to
investigate
the
influence
of
curcumin
(CUR)
on
CRC.
The
efficacies
CUR
malignant
phenotype
CRC
cells
were
determined
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl
tetrazolium
bromide,
wound
healing,
clonogenic
assays.
effects
evaluated
transmission
electron
microscopy,
lactate
dehydrogenase
release
assay,
Fe
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 1, 2024
Copper
plays
vital
roles
in
numerous
cellular
processes
and
its
imbalance
can
lead
to
oxidative
stress
dysfunction.
Recent
research
has
unveiled
a
unique
form
of
copper-induced
cell
death,
termed
cuproptosis,
which
differs
from
known
death
mechanisms.
This
process
involves
the
interaction
copper
with
lipoylated
tricarboxylic
acid
cycle
enzymes,
causing
protein
aggregation
death.
Recently,
growing
number
studies
have
explored
link
between
cuproptosis
cancer
development.
review
comprehensively
examines
systemic
metabolism
copper,
including
tumor-related
signaling
pathways
influenced
by
copper.
It
delves
into
discovery
mechanisms
connection
various
cancers.
Additionally,
suggests
potential
treatments
using
ionophores
that
induce
combination
small
molecule
drugs,
for
precision
therapy
specific
types.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(26)
Опубликована: Авг. 4, 2023
Abstract
The
application
of
nanomaterials
in
healthcare
has
emerged
as
a
promising
strategy
due
to
their
unique
structural
diversity,
surface
properties,
and
compositional
diversity.
In
particular,
have
found
significant
role
improving
drug
delivery
inhibiting
the
growth
metastasis
tumor
cells.
Moreover,
recent
studies
highlighted
potential
modulating
microenvironment
(TME)
enhancing
activity
immune
cells
improve
therapy
efficacy.
Various
types
are
currently
utilized
carriers,
immunosuppressants,
activators,
immunoassay
reagents,
more
for
immunotherapy.
Necessarily,
used
immunotherapy
can
be
grouped
into
two
categories:
organic
inorganic
nanomaterials.
Though
both
shown
ability
achieve
purpose
immunotherapy,
composition
properties
result
differences
mechanisms
modes
action.
Organic
further
divided
polymers,
cell
membranes,
nanoemulsion‐modified,
hydrogel
forms.
At
same
time,
broadly
classified
nonmetallic
metallic
current
work
aims
explore
action
these
different
prospects
promoting
Abstract
Nanomedicine‐assisted
sonodynamic
therapy
(SDT)
has
emerged
as
one
of
the
most
promising
cancer
therapies
due
to
its
unique
advantages
high
penetration,
non‐radiation,
and
excellent
oxidative
stress
effect,
but
always
suffered
from
self‐protection
mechanism
apoptosis
resistance
characteristics
evolutionarily
mutated
cells.
Regulated
cell
death
(RCD)
received
increasing
attention
in
precision
treatments
because
significant
role
synergistically
sensitizing
reversing
immunosuppressive
microenvironment
during
SDT
nanomedicine‐triggered
immunogenic
death.
Herein,
paradigmatic
research
RCD‐augmented
tumor
immunotherapeutics
are
typically
introduced,
such
autophagy
blockade,
ferroptosis
targeting,
pyroptosis
induction,
necroptosis
initiation,
cuproptosis
actuation,
PANoptosis
trigger,
coordinated
anti‐tumor
mechanisms
discussed
detail.
Multiple
analysis
focusing
on
currently
unsolved
problems
future
development
prospects
RCD‐based
nano‐oncology
medicine
also
prospected
further
strengthen
expand
scope
therapeutic
applications.
