Blood, Journal Year: 2023, Volume and Issue: 142(13), P. 1143 - 1155
Published: June 9, 2023
Language: Английский
Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(11), P. 1620 - 1653
Published: Nov. 1, 2022
The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue the processor cell, together with nucleus other they constitute mitochondrial information processing system (MIPS). In a three-step process, (1) sense respond to both endogenous environmental inputs through morphological functional remodeling; (2) integrate network-based physical interactions diffusion mechanisms; (3) produce output signals tune functions systemically regulate physiology. This input-to-output transformation allows metabolic, biochemical, neuroendocrine, local or systemic enhance organismal adaptation. An explicit focus on signal transduction emphasizes role communication in biology. framework also opens new avenues understand how mediate inter-organ processes underlying human health.
Language: Английский
Citations
320
Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(6), P. 424 - 442
Published: Feb. 16, 2024
Language: Английский
Citations
266
Trends in Cell Biology, Journal Year: 2023, Volume and Issue: 33(12), P. 1077 - 1087
Published: July 3, 2023
Language: Английский
Citations
216
Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 24(5), P. 312 - 333
Published: Dec. 21, 2022
Language: Английский
Citations
113
Molecular Cell, Journal Year: 2023, Volume and Issue: 83(7), P. 1030 - 1042
Published: March 27, 2023
Language: Английский
Citations
110
Trends in cancer, Journal Year: 2023, Volume and Issue: 9(5), P. 381 - 396
Published: Feb. 24, 2023
Language: Английский
Citations
105
Nature Cell Biology, Journal Year: 2024, Volume and Issue: 26(9), P. 1447 - 1457
Published: Feb. 29, 2024
Language: Английский
Citations
71
Nature Cell Biology, Journal Year: 2024, Volume and Issue: 26(9), P. 1434 - 1446
Published: June 20, 2024
Language: Английский
Citations
69
Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103211 - 103211
Published: May 30, 2024
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark ferroptosis uncontrolled overwhelming peroxidation polyunsaturated fatty acids contained membrane phospholipids, which eventually leads to rupture the plasma membrane. unique that it essentially spontaneous, uncatalyzed chemical process based on perturbed iron redox homeostasis contributing process, but nonetheless modulated by many metabolic nodes impinge cells' susceptibility ferroptosis. Among affecting sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets treatment numerous currently incurable diseases. Herein, current members Germany-wide research consortium focusing research, well key external experts who made seminal contributions this rapidly growing exciting field gathered provide comprehensive, state-of-the-art review Specific topics include: basic mechanisms, vivo relevance, specialized methodologies, tools, potential contribution disease etiopathology progression. We hope article will not only established scientists newcomers with an overview multiple facets ferroptosis, also encourage additional efforts characterize further molecular pathways modulating ultimate goal develop novel pharmacotherapies tackle associated - or caused
Language: Английский
Citations
62
Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(11), P. 799 - 813
Published: Sept. 25, 2023
Language: Английский
Citations
61