bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
Aminoacyl-tRNA
synthetases
(aaRSs)
are
essential
for
translation,
as
they
charge
tRNA
molecules
with
their
corresponding
amino
acids.
Alterations
in
aaRSs
can
significantly
disrupt
both
cytosolic
and
mitochondrial
translation.
Through
a
forward
genetic
screen
unfolded
protein
response
(UPR
mt
)
activators
C.
elegans
,
we
identified
missense
mutation
(P447V)
the
previously
uncharacterized
gene
Y105E8A.20,
which
encodes
dually
localized
methionine
synthetase
(MetRS).
Here,
characterize
UPR
induction
by
call
mars-2
demonstrate
that
P447V
allele
is
loss-of-function
mutation.
Furthermore,
show
impaired
activity
mitochondria
triggers
.
This
strain
provides
valuable
tool
studying
translation
understanding
how
involved
homeostasis.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(1), С. 380 - 380
Опубликована: Янв. 4, 2025
Plant
secondary
metabolites
(PSMs)
are
a
diverse
group
of
bioactive
compounds,
including
flavonoids,
polyphenols,
saponins,
and
terpenoids,
which
have
been
recognised
for
their
critical
role
in
modulating
cellular
functions.
This
review
provides
comprehensive
analysis
the
effects
PSMs
on
mitochondrial
health,
with
particular
emphasis
therapeutic
potential.
Emerging
evidence
shows
that
these
improve
function
by
reducing
oxidative
stress,
promoting
biogenesis,
regulating
key
processes
such
as
apoptosis
mitophagy.
Mitochondrial
dysfunction,
hallmark
many
pathologies,
neurodegenerative
disorders,
cardiovascular
diseases,
metabolic
syndrome,
has
shown
to
benefit
from
protective
PSMs.
Recent
studies
show
can
dynamics,
stabilise
membranes,
enhance
bioenergetics,
offering
significant
promise
prevention
treatment
mitochondrial-related
diseases.
The
molecular
mechanisms
underlying
effects,
modulation
signalling
pathways
direct
interactions
proteins,
discussed.
integration
into
strategies
is
highlighted
promising
avenue
improving
efficacy
while
minimising
side
commonly
associated
synthetic
drugs.
also
highlights
need
future
research
elucidate
specific
roles
individual
synergistic
within
complex
plant
matrices,
may
further
optimise
utility.
Overall,
this
work
valuable
insights
health
potential
natural
agents
targeting
dysfunction.
Cell Metabolism,
Год журнала:
2024,
Номер
36(9), С. 1963 - 1978
Опубликована: Авг. 23, 2024
SummaryOxidative
phosphorylation
(OXPHOS)
occurs
through
and
across
the
inner
mitochondrial
membrane
(IMM).
Mitochondrial
membranes
contain
a
distinct
lipid
composition,
aided
by
biosynthetic
machinery
localized
in
IMM
class-specific
transporters
that
limit
traffic
out
of
mitochondria.
This
unique
composition
appears
to
be
essential
for
functions
mitochondria,
particularly
OXPHOS,
its
effects
on
direct
lipid-to-protein
interactions,
properties,
cristae
ultrastructure.
review
highlights
biological
significance
lipids,
with
particular
spotlight
role
lipids
bioenergetics.
We
describe
pathways
biosynthesis
provide
evidence
their
roles
physiology,
implications
human
disease,
mechanisms
which
they
regulate
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 8, 2024
Abstract
Inflammatory
infiltration
of
synovial
M1
macrophages,
high
levels
ROS,
and
NO
exacerbate
osteoarthritis
(OA)
progression.
The
PdZn/Co
SA
‐NC
nanozymes,
which
are
highly
ordered
PdZn
intermetallic
nanoparticles
loaded
with
Co
single
atom
N‐doped
carbon‐rich
in
multi‐level
pores,
an
attempt
to
serve
as
SOD
CAT
mimicking
nanozymes
for
OA
therapy
is
designed.
nanozymes'
electron
transfer
dual
active
site
sufficient
exposure
enhances
free
radical
adsorption
lower
reaction
energies,
accelerating
SOD‐like,
CAT‐like,
GPx‐like
catalyzed
reactions,
outperforming
PdZn/NC
alone.
Furthermore,
exhibit
favorable
biocompatibility,
reduce
macrophage
oxidative
stress
OA,
alleviate
hypoxia,
restore
mitochondrial
function,
regulate
energy
metabolism,
increase
antioxidant
factors,
inflammatory
thus
effectively
mitigating
the
progression
OA.
Mechanistically,
downregulate
M1‐type
phenotypic
markers
like
IL‐1β
by
regulating
purine
metabolism.
offer
a
novel
approach
treating
stress‐related
diseases.
Redox Biology,
Год журнала:
2024,
Номер
77, С. 103406 - 103406
Опубликована: Окт. 22, 2024
Cerebral
ischemia-reperfusion
injury
(CIRI)
refers
to
a
secondary
brain
that
occurs
when
blood
supply
is
restored
ischemic
tissue
and
one
of
the
leading
causes
adult
disability
mortality.
Multiple
pathological
mechanisms
are
involved
in
progression
CIRI,
including
neuronal
oxidative
stress
mitochondrial
dysfunction.
Isoliquiritigenin
(ISL)
has
been
preliminarily
reported
have
potential
neuroprotective
effects
on
rats
subjected
cerebral
insult.
However,
protective
ISL
not
elucidated.
This
study
aims
further
investigate
ISL-mediated
neuroprotection
elucidate
underlying
molecular
mechanism.
The
findings
indicate
treatment
significantly
alleviated
middle
artery
occlusion
(MCAO)-induced
infarction,
neurological
deficits,
histopathological
damage,
apoptosis
mice.
In
vitro,
effectively
mitigated
reduction
cell
viability,
Na
Journal of Inflammation Research,
Год журнала:
2025,
Номер
Volume 18, С. 115 - 126
Опубликована: Янв. 1, 2025
Abstract:
Diabetic
periodontitis
is
a
common
oral
complication
of
diabetes
characterized
by
progressive
destruction
periodontal
tissues.
Recent
evidence
suggests
that
mitochondrial
dysfunction
plays
crucial
role
in
the
pathogenesis
and
progression
this
condition.
This
review
aims
to
systematically
summarize
potential
mechanisms
diabetic
periodontitis.
We
first
explore
relationship
between
dysfunction,
then
analyze
specific
manifestations
periodontitis,
including
morphological
changes,
energy
metabolism
disorders,
increased
oxidative
stress,
enhanced
apoptosis.
further
delve
into
connections
pathogenic
such
as
exacerbated
inflammatory
responses,
decreased
tissue
repair
capacity,
autophagy
dysregulation.
Finally,
we
discuss
therapeutic
targets
based
on
function,
antioxidant
strategies,
mitochondria-targeted
drugs,
regulators.
also
propose
future
research
directions,
emphasizing
need
for
in-depth
exploration
molecular
mechanisms,
development
new
diagnostic
markers
personalized
treatment
approaches.
provides
insights
understanding
offers
theoretical
basis
developing
targeted
prevention
strategies
improve
health
patients.
Keywords:
inflammation,
Bioconjugate Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Herein,
a
water-soluble,
ultrabright,
near-infrared
(NIR)
fluorescent,
mechanically
interlocked
molecules
(MIMs)-peptide
bioconjugate
is
designed
with
dual
targeting
capabilities.
Cancer
cell
surface
overexpressed
α
