YTHDC1 Regulates the Migration, Invasion, Proliferation, and Apoptosis of Rheumatoid Fibroblast-Like Synoviocytes DOI Creative Commons

Zhi‐wei Feng,

Chen-fei Yang,

Hefang Xiao

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Окт. 29, 2024

Rheumatoid arthritis (RA), a chronic autoimmune condition, is characterized by persistent synovial inflammation, bone degradation, and progressive joint deterioration. Despite considerable research efforts, the precise molecular mechanism underlying RA remains elusive. This investigation aims to elucidate potential role of N6-methyladenosine (m

Язык: Английский

RNA m6A modification in ferroptosis: implications for advancing tumor immunotherapy DOI Creative Commons

Jun-Xiao Shi,

Zhichao Zhang, Hao-zan Yin

и другие.

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Сен. 28, 2024

Язык: Английский

Процитировано

7
Epigenetic Mechanisms in Osteoporosis: Exploring the Power of m6A RNA Modification DOI Creative Commons
Shuo Tian,

Yagang Song,

Lin Guo

и другие.

Journal of Cellular and Molecular Medicine, Год журнала: 2025, Номер 29(1)

Опубликована: Янв. 1, 2025

ABSTRACT Osteoporosis, recognised as a metabolic disorder, has emerged significant burden on global health. Although available treatments have made considerable advancements, they remain inadequately addressed. In recent years, the role of epigenetic mechanisms in skeletal disorders garnered substantial attention, particularly concerning m 6 A RNA modification. is most prevalent dynamic and reversible modification eukaryotes, mediating various processes mRNAs, including splicing, structural conversion, translation, translocation degradation serves crucial component Research increasingly validated that plays vital proliferation, differentiation, migration, invasion,and repair bone marrow mesenchymal stem cells (BMSCs), osteoblasts osteoclasts, all which impact whole process osteoporosis pathogenesis. Continuous efforts been to target regulators natural products derived from traditional medicine, exhibit multiple biological activities such anti‐inflammatory anticancer effects, valuable resources for drug discovery. This paper elaborates methylation its regulatory osteoporosis, emphasising implications diagnosis treatment, thereby providing theoretical references.

Язык: Английский

Процитировано

0
Regulation of protein arginine methyltransferase in osteoporosis: a narrative review DOI Creative Commons
Ruiming Wen, Ruiqi Huang, Mingbo Yang

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Апрель 24, 2025

Osteoporosis (OP), a systemic bone disease characterised by increased fragility and susceptibility to fracture, is mainly caused decline in mineral density (BMD) quality an imbalance between formation resorption. Protein arginine methyltransferases (PRMTs) are epigenetic factors post-translational modification (PTM) enzymes participating various biological processes, including mRNA splicing, DNA damage repair, transcriptional regulation, cell signalling. They act catalysing the transfer of residues and, thus, have become therapeutic targets for OP. In-depth studies found that these also play key roles matrix protein metabolism, skeletal proliferation differentiation, signal pathway regulation regulate formation, resorption balance, or both jointly maintain health stability. However, expression changes mechanisms action multiple members PRMT family differ Therefore, this paper discusses functions, action, influencing PRMTs OP, which expected provide new understanding pathogenesis Furthermore, we present theoretical support development more precise effective treatment strategies as well further study molecular PRMTs.

Язык: Английский

Процитировано

0
Unraveling Key m6A Modification Regulators Signatures in Postmenopausal Osteoporosis through Bioinformatics and Experimental Verification DOI Creative Commons

Zhi‐wei Feng,

Hefang Xiao,

Xingwen Wang

и другие.

Orthopaedic Surgery, Год журнала: 2024, Номер 16(6), С. 1418 - 1433

Опубликована: Апрель 24, 2024

Bone marrow mesenchymal stem cells (BMSCs) show significant potential for osteogenic differentiation. However, the underlying mechanisms of capability in osteoporosis-derived BMSCs (OP-BMSCs) remain unclear. This study aims to explore impact YTHDF3 (YTH N6-methyladenosine RNA binding protein 3) on traits OP-BMSCs and identify therapeutic targets boost their bone formation ability.

Язык: Английский

Процитировано

3
YTHDC1 Regulates the Migration, Invasion, Proliferation, and Apoptosis of Rheumatoid Fibroblast-Like Synoviocytes DOI Creative Commons

Zhi‐wei Feng,

Chen-fei Yang,

Hefang Xiao

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Окт. 29, 2024

Rheumatoid arthritis (RA), a chronic autoimmune condition, is characterized by persistent synovial inflammation, bone degradation, and progressive joint deterioration. Despite considerable research efforts, the precise molecular mechanism underlying RA remains elusive. This investigation aims to elucidate potential role of N6-methyladenosine (m

Язык: Английский

Процитировано

0