YTHDC1 Regulates the Migration, Invasion, Proliferation, and Apoptosis of Rheumatoid Fibroblast-Like Synoviocytes DOI Creative Commons

Zhi‐wei Feng,

Chen-fei Yang,

Hefang Xiao

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 29, 2024

Rheumatoid arthritis (RA), a chronic autoimmune condition, is characterized by persistent synovial inflammation, bone degradation, and progressive joint deterioration. Despite considerable research efforts, the precise molecular mechanism underlying RA remains elusive. This investigation aims to elucidate potential role of N6-methyladenosine (m

Language: Английский

RNA m6A modification in ferroptosis: implications for advancing tumor immunotherapy DOI Creative Commons

Jun-Xiao Shi,

Zhichao Zhang, Hao-zan Yin

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 28, 2024

Language: Английский

Citations

7
Epigenetic Mechanisms in Osteoporosis: Exploring the Power of m6A RNA Modification DOI Creative Commons
Shuo Tian,

Yagang Song,

Lin Guo

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(1)

Published: Jan. 1, 2025

ABSTRACT Osteoporosis, recognised as a metabolic disorder, has emerged significant burden on global health. Although available treatments have made considerable advancements, they remain inadequately addressed. In recent years, the role of epigenetic mechanisms in skeletal disorders garnered substantial attention, particularly concerning m 6 A RNA modification. is most prevalent dynamic and reversible modification eukaryotes, mediating various processes mRNAs, including splicing, structural conversion, translation, translocation degradation serves crucial component Research increasingly validated that plays vital proliferation, differentiation, migration, invasion,and repair bone marrow mesenchymal stem cells (BMSCs), osteoblasts osteoclasts, all which impact whole process osteoporosis pathogenesis. Continuous efforts been to target regulators natural products derived from traditional medicine, exhibit multiple biological activities such anti‐inflammatory anticancer effects, valuable resources for drug discovery. This paper elaborates methylation its regulatory osteoporosis, emphasising implications diagnosis treatment, thereby providing theoretical references.

Language: Английский

Citations

0
Regulation of protein arginine methyltransferase in osteoporosis: a narrative review DOI Creative Commons
Ruiming Wen, Ruiqi Huang, Mingbo Yang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: April 24, 2025

Osteoporosis (OP), a systemic bone disease characterised by increased fragility and susceptibility to fracture, is mainly caused decline in mineral density (BMD) quality an imbalance between formation resorption. Protein arginine methyltransferases (PRMTs) are epigenetic factors post-translational modification (PTM) enzymes participating various biological processes, including mRNA splicing, DNA damage repair, transcriptional regulation, cell signalling. They act catalysing the transfer of residues and, thus, have become therapeutic targets for OP. In-depth studies found that these also play key roles matrix protein metabolism, skeletal proliferation differentiation, signal pathway regulation regulate formation, resorption balance, or both jointly maintain health stability. However, expression changes mechanisms action multiple members PRMT family differ Therefore, this paper discusses functions, action, influencing PRMTs OP, which expected provide new understanding pathogenesis Furthermore, we present theoretical support development more precise effective treatment strategies as well further study molecular PRMTs.

Language: Английский

Citations

0
Unraveling Key m6A Modification Regulators Signatures in Postmenopausal Osteoporosis through Bioinformatics and Experimental Verification DOI Creative Commons

Zhi‐wei Feng,

Hefang Xiao,

Xingwen Wang

et al.

Orthopaedic Surgery, Journal Year: 2024, Volume and Issue: 16(6), P. 1418 - 1433

Published: April 24, 2024

Bone marrow mesenchymal stem cells (BMSCs) show significant potential for osteogenic differentiation. However, the underlying mechanisms of capability in osteoporosis-derived BMSCs (OP-BMSCs) remain unclear. This study aims to explore impact YTHDF3 (YTH N6-methyladenosine RNA binding protein 3) on traits OP-BMSCs and identify therapeutic targets boost their bone formation ability.

Language: Английский

Citations

3
YTHDC1 Regulates the Migration, Invasion, Proliferation, and Apoptosis of Rheumatoid Fibroblast-Like Synoviocytes DOI Creative Commons

Zhi‐wei Feng,

Chen-fei Yang,

Hefang Xiao

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 29, 2024

Rheumatoid arthritis (RA), a chronic autoimmune condition, is characterized by persistent synovial inflammation, bone degradation, and progressive joint deterioration. Despite considerable research efforts, the precise molecular mechanism underlying RA remains elusive. This investigation aims to elucidate potential role of N6-methyladenosine (m

Language: Английский

Citations

0