Neurobiology of Disease,
Год журнала:
2023,
Номер
183, С. 106164 - 106164
Опубликована: Май 20, 2023
Phototherapy
is
an
emerging
non-pharmacological
treatment
for
depression,
circadian
rhythm
disruptions,
and
neurodegeneration,
as
well
pain
conditions
including
migraine
fibromyalgia.
However,
the
mechanism
of
phototherapy-induced
antinociception
not
understood.
Here,
using
fiber
photometry
recordings
population-level
neural
activity
combined
with
chemogenetics,
we
found
that
phototherapy
elicits
via
regulation
ventral
lateral
geniculate
body
(vLGN)
located
in
visual
system.
Specifically,
both
green
red
lights
caused
increase
c-fos
vLGN,
light
increased
more.
In
causes
a
large
glutamatergic
neurons,
whereas
GABAergic
neurons.
Green
preconditioning
increases
sensitivity
neurons
to
noxious
stimuli
vLGN
PSL
mice.
produces
by
activating
promotes
nociception
vLGN.
Together,
these
results
demonstrate
different
colors
exert
modulation
effects
regulating
subpopulations
This
may
provide
potential
new
therapeutic
strategies
targets
precise
clinical
neuropathic
pain.
Science,
Год журнала:
2025,
Номер
387(6734), С. 682 - 688
Опубликована: Фев. 6, 2025
Fast
instinctive
responses
to
environmental
stimuli
can
be
crucial
for
survival
but
are
not
always
optimal.
Animals
adapt
their
behavior
and
suppress
reactions,
the
neural
pathways
mediating
such
ethologically
relevant
forms
of
learning
remain
unclear.
We
found
that
posterolateral
higher
visual
areas
(plHVAs)
escapes
from
innate
threats
through
a
top-down
pathway
ventrolateral
geniculate
nucleus
(vLGN).
plHVAs
no
longer
necessary
after
learning;
instead,
learned
relies
on
plasticity
within
vLGN
populations
exert
inhibitory
control
over
escape
responses.
neurons
receiving
input
enhance
threat
during
endocannabinoid-mediated
long-term
suppression
inputs.
thus
reveal
detailed
circuit,
cellular,
synaptic
mechanisms
underlying
experience-dependent
fear
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 2, 2025
Alzheimer's
disease
is
characterized
by
progressive
amyloid
deposition
and
cognitive
decline,
yet
the
pathological
mechanisms
treatments
remain
elusive.
Here
we
report
therapeutic
potential
of
low-intensity
40
hertz
blue
light
exposure
in
a
5xFAD
mouse
model
disease.
Our
findings
reveal
that
treatment
prevents
memory
decline
4-month-old
mice
motivation
loss
14-month-old
mice,
accompanied
restoration
glial
water
channel
aquaporin-4
polarity,
improved
brain
drainage
efficiency,
reduction
hippocampal
lipid
accumulation.
We
further
demonstrate
beneficial
effects
are
mediated
through
activation
vLGN/IGL-Re
visual
circuit.
Notably,
concomitant
use
anti-Aβ
antibody
with
demonstrates
soluble
Aβ
clearance
performance
mice.
These
offer
functional
evidence
on
Aβ-related
pathologies
suggest
its
as
supplementary
strategy
to
augment
efficacy
antibody-based
therapy.
Treatments
for
(AD)
limited.
Here,
authors
show
activates
circuit
boost
glymphatic
drainage,
enhances
memory,
motivation,
therapy
AD.
Frontiers in Neural Circuits,
Год журнала:
2022,
Номер
16
Опубликована: Апрель 29, 2022
The
superior
colliculus
(SC)
is
a
highly
conserved
area
of
the
mammalian
midbrain
that
widely
implicated
in
organisation
and
control
behaviour.
SC
receives
input
from
large
number
brain
areas,
provides
outputs
to
areas.
convergence
divergence
anatomical
connections
with
different
areas
systems
challenges
for
understanding
how
contributes
Recent
work
mouse
has
provided
datasets,
wealth
new
data
experiments
identify
manipulate
cells
within
SC,
their
inputs
outputs,
during
simple
behaviours.
These
offer
an
opportunity
better
understand
roles
plays
these
However,
some
observations
appear,
at
first
sight,
be
contradictory.
Here
we
review
this
recent
hypothesise
framework
which
can
capture
observations,
requires
only
small
change
previous
models.
Specifically,
functional
explained
by
supposing
three
largely
distinct
circuits
support
classes
behaviours–arrest,
turning
towards,
triggering
escape
or
capture.
behaviours
are
hypothesised
supported
optic,
intermediate
deep
layers,
respectively.
Light
modulates
mood
through
various
retina-brain
pathways.
We
showed
that
mice
treated
with
short-term
acute
bright
light
exposure
displayed
anxiety-related
phenotypes
in
a
prolonged
manner
even
after
the
termination
of
exposure.
Such
postexposure
anxiogenic
effect
depended
upon
melanopsin-based
intrinsically
photosensitive
retinal
ganglion
cell
(ipRGC)
activities
rather
than
rod/cone
photoreceptor
inputs.
Chemogenetic
manipulation
specific
central
nuclei
demonstrated
ipRGC-central
amygdala
(CeA)
visual
circuit
played
key
role
this
effect.
The
corticosterone
system
was
likely
to
be
involved
effect,
as
evidenced
by
enhanced
expression
glucocorticoid
receptor
(GR)
protein
CeA
and
bed
nucleus
stria
terminalis
absence
animals
GR
antagonist.
Together,
our
findings
reveal
non-image
forming
specifically
designed
for
"the
delayed"
extinction
anxiety
against
potential
threats,
thus
conferring
survival
advantage.
Neuroscience Bulletin,
Год журнала:
2022,
Номер
39(2), С. 245 - 260
Опубликована: Окт. 19, 2022
Defensive
behaviors
induced
by
innate
fear
or
Pavlovian
conditioning
are
crucial
for
animals
to
avoid
threats
and
ensure
survival.
The
zona
incerta
(ZI)
has
been
demonstrated
play
important
roles
in
learning
memory,
as
well
modulating
auditory-induced
defensive
behavior.
However,
whether
the
neuronal
subtypes
ZI
specific
circuits
can
mediate
response
is
largely
unknown.
Here,
we
found
that
somatostatin
(SST)-positive
neurons
rostral
of
mice
were
activated
a
visual
stimulus.
Optogenetic
inhibition
SST-positive
resulted
reduced
flight
responses
an
overhead
looming
activation
fear-like
behavior
including
increased
immobility
bradycardia.
In
addition,
manipulation
GABAergic
projections
from
downstream
nucleus
reuniens
(Re)
mediated
Retrograde
trans-synaptic
tracing
also
revealed
stimulus-activated
superior
colliculus
(SC)
projected
Re-projecting
(SC-ZIrSST-Re
pathway).
Together,
our
study
elucidates
function
SC-ZIrSST-Re
tri-synaptic
circuit
mediating
response.
Behavioral
flexibility
requires
directing
feedforward
sensory
information
to
appropriate
targets.
In
the
superior
colliculus,
divergent
outputs
orchestrate
different
responses
visual
threats,
but
circuit
organization
enabling
flexible
routing
of
remains
unknown.
To
determine
this
structure,
we
focused
on
inhibitory
projection
(Gad2)
neurons.
Trans-synaptic
tracing
and
neuronal
recordings
revealed
that
Gad2
neurons
projecting
lateral
geniculate
nucleus
(LGN)
parabigeminal
(PBG)
form
two
separate
populations,
each
receiving
a
set
non-retinal
inputs.
Inhibiting
LGN-
or
PBG-projecting
resulted
in
opposing
effects
behavior;
increasing
freezing
escape
probability
looming,
respectively.
Optogenetic
activation
selected
inputs
cells
predictably
regulated
threat.
These
data
suggest
projection-specific
sampling
brain-wide
provides
design
principle
enables
be
selectively
routed
produce
context-specific
behavior.