Glutamatergic and GABAergic neurons in the vLGN mediate the nociceptive effects of green and red light on neuropathic pain DOI Creative Commons
Xueqing Wu, Bei Tan, Yu Du

и другие.

Neurobiology of Disease, Год журнала: 2023, Номер 183, С. 106164 - 106164

Опубликована: Май 20, 2023

Phototherapy is an emerging non-pharmacological treatment for depression, circadian rhythm disruptions, and neurodegeneration, as well pain conditions including migraine fibromyalgia. However, the mechanism of phototherapy-induced antinociception not understood. Here, using fiber photometry recordings population-level neural activity combined with chemogenetics, we found that phototherapy elicits via regulation ventral lateral geniculate body (vLGN) located in visual system. Specifically, both green red lights caused increase c-fos vLGN, light increased more. In causes a large glutamatergic neurons, whereas GABAergic neurons. Green preconditioning increases sensitivity neurons to noxious stimuli vLGN PSL mice. produces by activating promotes nociception vLGN. Together, these results demonstrate different colors exert modulation effects regulating subpopulations This may provide potential new therapeutic strategies targets precise clinical neuropathic pain.

Язык: Английский

Overwriting an instinct: Visual cortex instructs learning to suppress fear responses DOI
Sara Mederos, Pennelope Blakely, Nicole Vissers

и другие.

Science, Год журнала: 2025, Номер 387(6734), С. 682 - 688

Опубликована: Фев. 6, 2025

Fast instinctive responses to environmental stimuli can be crucial for survival but are not always optimal. Animals adapt their behavior and suppress reactions, the neural pathways mediating such ethologically relevant forms of learning remain unclear. We found that posterolateral higher visual areas (plHVAs) escapes from innate threats through a top-down pathway ventrolateral geniculate nucleus (vLGN). plHVAs no longer necessary after learning; instead, learned relies on plasticity within vLGN populations exert inhibitory control over escape responses. neurons receiving input enhance threat during endocannabinoid-mediated long-term suppression inputs. thus reveal detailed circuit, cellular, synaptic mechanisms underlying experience-dependent fear

Язык: Английский

Процитировано

5
Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer’s disease DOI Creative Commons
Wen Wu,

Yubai Zhao,

Xin Cheng

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 2, 2025

Alzheimer's disease is characterized by progressive amyloid deposition and cognitive decline, yet the pathological mechanisms treatments remain elusive. Here we report therapeutic potential of low-intensity 40 hertz blue light exposure in a 5xFAD mouse model disease. Our findings reveal that treatment prevents memory decline 4-month-old mice motivation loss 14-month-old mice, accompanied restoration glial water channel aquaporin-4 polarity, improved brain drainage efficiency, reduction hippocampal lipid accumulation. We further demonstrate beneficial effects are mediated through activation vLGN/IGL-Re visual circuit. Notably, concomitant use anti-Aβ antibody with demonstrates soluble Aβ clearance performance mice. These offer functional evidence on Aβ-related pathologies suggest its as supplementary strategy to augment efficacy antibody-based therapy. Treatments for (AD) limited. Here, authors show activates circuit boost glymphatic drainage, enhances memory, motivation, therapy AD.

Язык: Английский

Процитировано

3
A visual circuit related to the periaqueductal gray area for the antinociceptive effects of bright light treatment DOI Creative Commons

Zhengfang Hu,

Yi-Man Mu,

Lu Huang

и другие.

Neuron, Год журнала: 2022, Номер 110(10), С. 1712 - 1727.e7

Опубликована: Март 8, 2022

Язык: Английский

Процитировано

41
Functional Organisation of the Mouse Superior Colliculus DOI Creative Commons
Thomas Wheatcroft, Aman B. Saleem, Samuel G. Solomon

и другие.

Frontiers in Neural Circuits, Год журнала: 2022, Номер 16

Опубликована: Апрель 29, 2022

The superior colliculus (SC) is a highly conserved area of the mammalian midbrain that widely implicated in organisation and control behaviour. SC receives input from large number brain areas, provides outputs to areas. convergence divergence anatomical connections with different areas systems challenges for understanding how contributes Recent work mouse has provided datasets, wealth new data experiments identify manipulate cells within SC, their inputs outputs, during simple behaviours. These offer an opportunity better understand roles plays these However, some observations appear, at first sight, be contradictory. Here we review this recent hypothesise framework which can capture observations, requires only small change previous models. Specifically, functional explained by supposing three largely distinct circuits support classes behaviours–arrest, turning towards, triggering escape or capture. behaviours are hypothesised supported optic, intermediate deep layers, respectively.

Язык: Английский

Процитировано

32
The caudal prethalamus: Inhibitory switchboard for behavioral control? DOI Creative Commons
Alex Fratzl, Sonja B. Hofer

Neuron, Год журнала: 2022, Номер 110(17), С. 2728 - 2742

Опубликована: Сен. 1, 2022

Язык: Английский

Процитировано

29
Short-term acute bright light exposure induces a prolonged anxiogenic effect in mice via a retinal ipRGC-CeA circuit DOI Creative Commons
Ge Wang, Yunfeng Liu,

Zhe Yang

и другие.

Science Advances, Год журнала: 2023, Номер 9(12)

Опубликована: Март 22, 2023

Light modulates mood through various retina-brain pathways. We showed that mice treated with short-term acute bright light exposure displayed anxiety-related phenotypes in a prolonged manner even after the termination of exposure. Such postexposure anxiogenic effect depended upon melanopsin-based intrinsically photosensitive retinal ganglion cell (ipRGC) activities rather than rod/cone photoreceptor inputs. Chemogenetic manipulation specific central nuclei demonstrated ipRGC-central amygdala (CeA) visual circuit played key role this effect. The corticosterone system was likely to be involved effect, as evidenced by enhanced expression glucocorticoid receptor (GR) protein CeA and bed nucleus stria terminalis absence animals GR antagonist. Together, our findings reveal non-image forming specifically designed for "the delayed" extinction anxiety against potential threats, thus conferring survival advantage.

Язык: Английский

Процитировано

22
Distinct circuits in anterior cingulate cortex encode safety assessment and mediate flexibility of fear reactions DOI Creative Commons
Kaibin Wu,

Dijia Wang,

Yuwei Wang

и другие.

Neuron, Год журнала: 2023, Номер 111(22), С. 3650 - 3667.e6

Опубликована: Авг. 30, 2023

Язык: Английский

Процитировано

19
Somatostatin-Positive Neurons in the Rostral Zona Incerta Modulate Innate Fear-Induced Defensive Response in Mice DOI Creative Commons
Shan Lin,

Mengyue Zhu,

Mengyu Tang

и другие.

Neuroscience Bulletin, Год журнала: 2022, Номер 39(2), С. 245 - 260

Опубликована: Окт. 19, 2022

Defensive behaviors induced by innate fear or Pavlovian conditioning are crucial for animals to avoid threats and ensure survival. The zona incerta (ZI) has been demonstrated play important roles in learning memory, as well modulating auditory-induced defensive behavior. However, whether the neuronal subtypes ZI specific circuits can mediate response is largely unknown. Here, we found that somatostatin (SST)-positive neurons rostral of mice were activated a visual stimulus. Optogenetic inhibition SST-positive resulted reduced flight responses an overhead looming activation fear-like behavior including increased immobility bradycardia. In addition, manipulation GABAergic projections from downstream nucleus reuniens (Re) mediated Retrograde trans-synaptic tracing also revealed stimulus-activated superior colliculus (SC) projected Re-projecting (SC-ZIrSST-Re pathway). Together, our study elucidates function SC-ZIrSST-Re tri-synaptic circuit mediating response.

Язык: Английский

Процитировано

25
Retinal origin of orientation but not direction selective maps in the superior colliculus DOI Creative Commons
Daniel de Malmazet, Norma K. Kühn, Chen Li

и другие.

Current Biology, Год журнала: 2024, Номер 34(6), С. 1222 - 1233.e7

Опубликована: Фев. 27, 2024

Язык: Английский

Процитировано

6
Pathway-specific inputs to the superior colliculus support flexible responses to visual threat DOI Creative Commons
Chen Li, Norma K. Kühn, Ilayda Alkislar

и другие.

Science Advances, Год журнала: 2023, Номер 9(35)

Опубликована: Авг. 30, 2023

Behavioral flexibility requires directing feedforward sensory information to appropriate targets. In the superior colliculus, divergent outputs orchestrate different responses visual threats, but circuit organization enabling flexible routing of remains unknown. To determine this structure, we focused on inhibitory projection (Gad2) neurons. Trans-synaptic tracing and neuronal recordings revealed that Gad2 neurons projecting lateral geniculate nucleus (LGN) parabigeminal (PBG) form two separate populations, each receiving a set non-retinal inputs. Inhibiting LGN- or PBG-projecting resulted in opposing effects behavior; increasing freezing escape probability looming, respectively. Optogenetic activation selected inputs cells predictably regulated threat. These data suggest projection-specific sampling brain-wide provides design principle enables be selectively routed produce context-specific behavior.

Язык: Английский

Процитировано

12