Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 17, 2023
Abstract
While
light
can
affect
emotional
and
cognitive
processes
of
the
medial
prefrontal
cortex
(mPFC),
no
light-encoding
was
hitherto
identified
in
this
region.
Here,
extracellular
recordings
awake
mice
revealed
that
over
half
studied
mPFC
neurons
showed
photosensitivity,
diminished
by
chemogenetic
inhibition
intrinsically
photosensitive
retinal
ganglion
cells
(ipRGCs),
or
upstream
thalamic
perihabenular
nucleus
(PHb).
In
15%
neurons,
firing
rate
changed
monotonically
along
light-intensity
steps
gradients.
These
light-intensity-encoding
comprised
four
types,
two
enhancing
suppressing
their
with
increased
intensity.
types
were
also
PHb,
where
they
exhibited
shorter
latency
sensitivity.
Light
suppressed
prelimbic
activity
but
boosted
infralimbic
activity,
mirroring
contrasting
roles
fear-conditioning,
drug-seeking,
anxiety.
We
posit
photosensitivity
represents
a
substrate
light-susceptible,
mPFC-mediated
functions,
which
could
as
therapeutical
target
psychiatric
addiction
disorders.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 2, 2025
Alzheimer's
disease
is
characterized
by
progressive
amyloid
deposition
and
cognitive
decline,
yet
the
pathological
mechanisms
treatments
remain
elusive.
Here
we
report
therapeutic
potential
of
low-intensity
40
hertz
blue
light
exposure
in
a
5xFAD
mouse
model
disease.
Our
findings
reveal
that
treatment
prevents
memory
decline
4-month-old
mice
motivation
loss
14-month-old
mice,
accompanied
restoration
glial
water
channel
aquaporin-4
polarity,
improved
brain
drainage
efficiency,
reduction
hippocampal
lipid
accumulation.
We
further
demonstrate
beneficial
effects
are
mediated
through
activation
vLGN/IGL-Re
visual
circuit.
Notably,
concomitant
use
anti-Aβ
antibody
with
demonstrates
soluble
Aβ
clearance
performance
mice.
These
offer
functional
evidence
on
Aβ-related
pathologies
suggest
its
as
supplementary
strategy
to
augment
efficacy
antibody-based
therapy.
Treatments
for
(AD)
limited.
Here,
authors
show
activates
circuit
boost
glymphatic
drainage,
enhances
memory,
motivation,
therapy
AD.
Chronobiology International,
Год журнала:
2025,
Номер
unknown, С. 1 - 23
Опубликована: Янв. 22, 2025
The
intricate
relationship
between
circadian
rhythms
and
mood
is
well-established.
Disturbances
in
sleep
often
precede
the
development
of
disorders,
such
as
major
depressive
disorder
(MDD),
bipolar
(BD),
seasonal
affective
(SAD).
Two
primary
factors,
intrinsic
clocks
light,
drive
natural
fluctuations
throughout
day,
mirroring
patterns
sleepiness
wakefulness.
Nearly
all
organisms
possess
that
coordinate
daily
rhythms,
with
light
serving
environmental
cue
to
synchronize
these
internal
timekeepers
24-hour
cycle.
Additionally,
directly
influences
states.
Disruptions
those
caused
by
jet
lag,
shift
work,
or
reduced
daylight
hours,
can
trigger
exacerbate
symptoms.
complex
subtle
connections
disruptions
dysregulation
suggest
focusing
solely
on
individual
clock
genes
insufficient
fully
understand
their
etiology
progression.
Instead,
instability
may
arise
from
systemic
misalignments
external
cycles
synchronization
clocks.
Here,
we
synthesize
past
research
independent
contributions
regulation,
drawing
particularly
insights
animal
studies
illuminate
fundamental
mechanisms
relevant
human
health.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июнь 29, 2024
Abstract
While
light
can
affect
emotional
and
cognitive
processes
of
the
medial
prefrontal
cortex
(mPFC),
no
light-encoding
was
hitherto
identified
in
this
region.
Here,
extracellular
recordings
awake
mice
revealed
that
over
half
studied
mPFC
neurons
showed
photosensitivity,
diminished
by
inhibition
intrinsically
photosensitive
retinal
ganglion
cells
(ipRGCs),
or
upstream
thalamic
perihabenular
nucleus
(PHb).
In
15%
neurons,
firing
rate
changed
monotonically
along
light-intensity
steps
gradients.
These
light-intensity-encoding
comprised
four
types,
two
enhancing
suppressing
their
with
increased
intensity.
Similar
types
were
PHb,
where
they
exhibited
shorter
latency
sensitivity.
Light
suppressed
prelimbic
activity
but
boosted
infralimbic
activity,
mirroring
regions’
contrasting
roles
fear-conditioning,
drug-seeking,
anxiety.
We
posit
photosensitivity
represents
a
substrate
light-susceptible,
mPFC-mediated
functions,
which
could
be
ultimately
as
therapeutical
target
psychiatric
addiction
disorders.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 18, 2025
Mitochondria
absorb
short
wavelengths
around
420
nm.
This
is
associated
with
reduced
ATP
and
restricted
mobility.
The
420–450
nm
range
a
significant
element
of
LED
lighting
computer
monitors.
Here
we
expose
freely
moving
mice
to
show
rapidly
weight
gain
within
week.
may
be
due
mitochondrial
demand
for
circulating
carbohydrates.
Both
groups
displayed
marked
shifts
in
serum
cytokines.
Open
field
mobility
was
examined.
distance
travelled
similar
between
both
experimental
their
controls.
However,
showed
avoidance
central
regions
consistent
anxiety-like
behaviours.
the
group
whose
wavelength
exposure
closer
peak
absorbance.
These
data
demonstrate
potential
hazards
specific
visual
now
common
built
environment.
Data
are
wider
literature
on
systemic
problems
arising
from
light.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 23, 2025
Beside
image
vision,
light
plays
a
pivotal
role
in
regulating
diverse
non-visual
functions,
including
affective
behaviors.
Recently,
bright
stimulation
(BLS)
was
revealed
to
be
beneficial
for
treating
non-seasonal
depression,
although
its
mechanism
of
action
is
not
fully
understood.
We
developed
novel
mouse
model
refractory
induced
through
social
isolation
and
chronic
despair
during
the
active
(dark)
phase
animal,
we
have
tested
if
antidepressant
treatments,
BLS,
could
protect
against
anxio-depressive-like
behavior.
report
that
anxiety-
depressive-like
behaviors
are
resistant
BLS
as
well
both
conventional
new
antidepressants,
ketamine.
Remarkably,
unveil
potentiates
effect
this
mediated
via
rod
retinal
photoreceptors.
Furthermore,
demonstrate
chemogenetic
activation
lateral
habenula
(LHb)
astroglia
serotonin
(5-HT)
depletion
prevent
potentiating
on
despair.
These
results
reveal,
first
time,
enhances
efficacy
antidepressants
an
unexpectedly
circuit
involving
rods,
LHb
5-HT.
