Brain stimulation, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Low-intensity focused ultrasound (LIFU) is a promising form of non-invasive neuromodulation characterized by rich parameter space that includes intensity, duration, duty cycle and pulsing strategy. The effect interaction these parameters to affect human brain activity poorly understood. A better understanding how interact critical advance LIFU as potential therapeutic.
Язык: Английский
Brain stimulation, Год журнала: 2024, Номер 17(2), С. 258 - 268
Опубликована: Март 1, 2024
BackgroundTheta burst TUS (tbTUS) can induce increased cortical excitability in human, but how different sonication parameters influence the effects are still unknown.ObjectiveTo examine a range of parameters, including acoustic intensity, pulse repetition frequency, duty cycle and duration, tbTUS on human motor excitability.Methods14 right-handed healthy subjects underwent 8 sessions with randomized, cross-over design separate days. The original protocol was studied one session parameter changed each seven sessions. To changes induced by tbTUS, we measured motor-evoked potential (MEP) amplitude, resting threshold, short-interval intracortical inhibition facilitation, as well facilitation before up to 90 min after tbTUS.ResultsAll conditions MEP amplitudes except condition low intensity 10 W/cm2. Pulse frequency 5 Hz produced higher compared frequencies 2 Hz. In addition, cycles (5%, 10%, 15%) longer durations (40, 80, 120 s) were associated duration amplitudes. Resting threshold remained stable all conditions. For paired-pulse TMS measures, reduced enhanced had no effect facilitation.ConclusionsUltrasound bursts repeated at theta (∼5 Hz) is optimal produce 2–10 Furthermore, there dose-response regarding for plasticity induction. aftereffects shift inhibition/excitation balance toward less more excitation cortex. These findings be used determine neuroscience research treatment neurological psychiatric disorders.
Язык: Английский
Процитировано
28
Biomedical Engineering Letters, Год журнала: 2024, Номер 14(3), С. 407 - 438
Опубликована: Март 2, 2024
Transcranial ultrasonic neuromodulation is a rapidly burgeoning field where low-intensity transcranial focused ultrasound (tFUS), with exquisite spatial resolution and deep tissue penetration, used to non-invasively activate or suppress neural activity in specific brain regions. Over the past decade, there has been rapid increase of tFUS studies healthy humans subjects central nervous system (CNS) disease conditions, including recent surge clinical investigations patients. This narrative review summarized findings human using either unfocused (TUS) reported from 2013 2023. The were categorized into two separate sections: research studies. A total 42 reviewed as grouped by targeted regions, various cortical, subcortical, areas thalamus. For research, 22 articles for each studied CNS condition, chronic pain, disorder consciousness, Alzheimer's disease, Parkinson's depression, schizophrenia, anxiety disorders, substance use disorder, drug-resistant epilepsy, stroke. Detailed information on subjects/cohorts, target sonication parameters, outcome readouts, stimulatory efficacies tabulated study. In later sections, considerations planning also concisely discussed. With an excellent safety profile date, growth underscores increasing interest recognition its significant potential non-invasive stimulation (NIBS), offering theranostic neurological psychiatric conditions neuroscientific tools functional mapping.
Язык: Английский
Процитировано
22
Journal of Neuroscience, Год журнала: 2024, Номер unknown, С. e1011232023 - e1011232023
Опубликована: Янв. 5, 2024
The dorsal anterior cingulate cortex (dACC) is a critical brain area for pain and autonomic processing, making it promising non-invasive therapeutic target. We leverage the high spatial resolution deep focal lengths of low-intensity focused ultrasound (LIFU) to non-invasively modulate dACC effects on behavioral cardiac responses using transient heat stimuli. N = 16 healthy human volunteers (6M/10F) received contact during either LIFU or Sham stimulation. Continuous electroencephalogram (EEG), electrocardiogram (ECG), electrodermal response (EDR) were recorded. Outcome measures included ratings, heart-rate variability, EDR response, blood pressure, amplitude heat-evoked potential (CHEP). reduced ratings by 1.09 ± 0.20 points relative Sham. increased heart rate variability indexed standard deviation normal sinus beats (SDNN), low frequency (LF) power, low-frequency/high-frequency (LF/HF) ratio. There no pressure EDR. resulted in 38.1% reduction P2 CHEP amplitude. Results demonstrate reduces alters acute This has implications causal understanding processing future options relief modulation homeostatic signals. Significance Statement New lines inquiry signals like (HRV) are aberrant chronic mental health disorders, which may contribute their underlying etiology. key center with direct influences function, but its depth precludes access without invasive surgery. For first time humans, we can selectively reduce perception, responses, work further establishes role clinical applications neuropsychological populations.
Язык: Английский
Процитировано
19
Clinical Neurophysiology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
3
Brain stimulation, Год журнала: 2024, Номер 17(2), С. 476 - 484
Опубликована: Март 1, 2024
BackgroundNon-invasive brain stimulation techniques such as transcranial magnetic and direct current hold promise for inducing plasticity. However, their limited precision may hamper certain applications. In contrast, Transcranial Ultrasound Stimulation (TUS), known its deep targeting capabilities, requires further investigation to establish efficacy in producing enduring effects treating neurological psychiatric disorders.ObjectiveTo investigate the of different pulse repetition frequencies (PRF) TUS on motor corticospinal excitability.MethodsT1-, T2-weighted, zero echo time resonance imaging scans were acquired from 21 neurologically healthy participants neuronavigation, skull reconstruction, performance ultrasound thermal modelling. The three PRFs (10, 100, 1000 Hz) with a constant duty cycle 10% excitability primary cortex assessed using TMS-induced evoked potentials (MEPs). Each PRF sham condition was evaluated separate days, measurements taken 5-, 30-, 60-minutes post-TUS.ResultsA significant decrease MEP amplitude observed 10 Hz (p = 0.007), which persisted at least 30 minutes, 100 0.001), lasting over 60 minutes. no changes found conditions.ConclusionThis study highlights significance selection underscores potential non-invasive approach reduce excitability, offering valuable insights future clinical
Язык: Английский
Процитировано
17
Brain stimulation, Год журнала: 2024, Номер 17(3), С. 636 - 647
Опубликована: Май 1, 2024
Язык: Английский
Процитировано
16
Brain stimulation, Год журнала: 2024, Номер 17(4), С. 734 - 751
Опубликована: Июнь 15, 2024
Low-intensity transcranial ultrasound has surged forward as a non-invasive and disruptive tool for neuromodulation with applications in basic neuroscience research the treatment of neurological psychiatric conditions. To provide comprehensive overview update preclinical clinical low intensity emphasize emerging role functional brain mapping to guide, better understand, predict responses. A systematic review was conducted by searching Web Science Scopus databases studies on neuromodulation, both humans animals. 187 relevant were identified reviewed, including 116 71 reports subjects belonging diverse cohorts. Milestones are described within an broader landscape. General neural readouts outcome measures discussed, potential confounds noted, use magnetic resonance imaging is highlighted. Ultrasound emerged powerful study treat range conditions its combination various significantly advanced this platform. In particular, yielded exciting inferences into advance our understanding function, neuromodulatory mechanisms, ultimately outcomes. It anticipated that these trials first many; focused ultrasound, particularly imaging, enhance spectrum
Язык: Английский
Процитировано
12
Brain stimulation, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
11
The Journal of Physiology, Год журнала: 2024, Номер 602(5), С. 933 - 948
Опубликована: Фев. 15, 2024
Abstract Non‐invasive brain stimulation has the potential to boost neuronal plasticity in primary motor cortex (M1), but it remains unclear whether of both superficial and deep layers human can effectively promote M1 plasticity. Here, we leveraged transcranial ultrasound (TUS) precisely target circuits at depths approximately 5 mm 16 from cortical surface. Initially, generated computed tomography images each participant's individual anatomical magnetic resonance (MRI), which allowed for generation accurate acoustic simulations. This process ensured that personalized TUS was administered exactly targeted within participant. Using long‐term depression potentiation (LTD/LTP) theta‐burst paradigms, examined over distinct could induce LTD/LTP Our findings indicated continuous TUS‐induced LTD‐like with stimulation, persisting least 30 min. In comparison, sham did not significantly alter excitability. Moreover, intermittent result induction LTP‐ or either stimulation. These suggest be achieved targeting M1, is contingent on characteristics TUS. image Key points The study integrated electrophysiology determine (M1) elicit (LTD) (LTP) plastic changes. Utilizing simulations derived individualized pseudo‐computed scans, precision delivery intended Continuous resulted emergence plasticity, lasting Administering lead We this effect dependent specific parameters.
Язык: Английский
Процитировано
10
Nature Communications, Год журнала: 2025, Номер 16(1)
Опубликована: Март 19, 2025
Transcranial ultrasound stimulation (TUS) offers precise, non-invasive neuromodulation, though its impact on human deep brain structures remains underexplored. Here we examined TUS-induced changes in the basal ganglia of 10 individuals with movement disorders (Parkinson's disease and dystonia) 15 healthy participants. Local field potentials were recorded using (DBS) leads globus pallidus internus (GPi). Compared to sham, theta burst TUS (tbTUS) increased power during stimulation, while Hz enhanced beta power, effects lasting up 40 min. In participants, a stop-signal task assessed tbTUS GPi, pulvinar serving as an active sham. GPi prolonged reaction times, indicating impaired response inhibition, whereas had no effect. These findings provide direct electrophysiological evidence target engagement specificity structures, suggesting potential noninvasive DBS strategy for neurological psychiatric disorders. is method modulate activity. Using recordings from implanted electrodes, showed that engages internus, neural oscillations behavior.
Язык: Английский
Процитировано
2