Small and long non-coding RNAs: Past, present, and future
Cell,
Год журнала:
2024,
Номер
187(23), С. 6451 - 6485
Опубликована: Ноя. 1, 2024
Язык: Английский
Synaptically-targeted long non-coding RNA SLAMR promotes structural plasticity by increasing translation and CaMKII activity
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Март 27, 2024
Long
noncoding
RNAs
(lncRNAs)
play
crucial
roles
in
maintaining
cell
homeostasis
and
function.
However,
it
remains
largely
unknown
whether
how
neuronal
activity
impacts
the
transcriptional
regulation
of
lncRNAs,
or
if
this
leads
to
synapse-related
changes
contributes
formation
long-term
memories.
Here,
we
report
identification
a
lncRNA,
SLAMR,
which
becomes
enriched
CA1-hippocampal
neurons
upon
contextual
fear
conditioning
but
not
CA3
neurons.
SLAMR
is
transported
along
dendrites
via
molecular
motor
KIF5C
recruited
synapse
stimulation.
Loss
function
reduces
dendritic
complexity
impairs
activity-dependent
spine
structural
plasticity
translation.
Gain
contrast,
enhances
complexity,
density,
Analyses
interactome
reveal
its
association
with
CaMKIIα
protein
through
220-nucleotide
element
also
involved
transport.
A
CaMKII
reporter
reveals
basal
reduction
loss-of-function.
Furthermore,
selective
loss
CA1
disrupts
consolidation
memory
male
mice,
without
affecting
their
acquisition,
recall,
extinction,
spatial
memory.
Together,
these
results
provide
new
functional
insight
into
at
fear.
Язык: Английский
Targeting neuronal epigenomes for brain rejuvenation
The EMBO Journal,
Год журнала:
2024,
Номер
43(16), С. 3312 - 3326
Опубликована: Июль 15, 2024
Abstract
Aging
is
associated
with
a
progressive
decline
of
brain
function,
and
the
underlying
causes
possible
interventions
to
prevent
this
cognitive
have
been
focus
intense
investigation.
The
maintenance
neuronal
function
over
lifespan
requires
proper
epigenetic
regulation,
accumulating
evidence
suggests
that
deterioration
landscape
contributes
dysfunction
during
aging.
Epigenetic
aging
neurons
may,
however,
be
malleable.
Recent
reports
shown
age-related
changes
in
reversible
targetable
by
rejuvenation
strategies
can
restore
This
review
discusses
current
identifies
as
driver
promising
target
strategies,
it
highlights
potential
approaches
for
specific
manipulation
epigenome
youthful
state
brain.
Язык: Английский
Efficacy of an AAV vector encoding a thermostable form of glucocerebrosidase in alleviating symptoms in a Gaucher disease mouse model
Gene Therapy,
Год журнала:
2024,
Номер
31(9-10), С. 439 - 444
Опубликована: Авг. 15, 2024
Almost
all
attempts
to
date
at
gene
therapy
approaches
for
monogenetic
disease
have
used
the
amino
acid
sequences
of
natural
protein.
In
current
study,
we
use
a
designed,
thermostable
form
glucocerebrosidase
(GCase),
enzyme
defective
in
Gaucher
(GD),
attempt
alleviate
neurological
symptoms
GD
mouse
that
models
type
3
disease,
i.e.
chronic
neuronopathic
juvenile
subtype.
Upon
injection
an
AAVrh10
(adeno-associated
virus,
serotype
rh10)
vector
containing
designed
GCase
(dGCase)
into
left
lateral
ventricle
Gba
Язык: Английский
Efficacy of an AAV vector encoding a thermostable form of glucocerebrosidase in alleviating symptoms in a Gaucher disease mouse model
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 19, 2024
Abstract
Almost
all
attempts
to
date
at
gene
therapy
approaches
for
monogenetic
disease
have
used
the
amino
acid
sequences
of
natural
protein.
In
current
study,
we
use
a
designed,
thermostable
form
glucocerebrosidase
(GCase),
enzyme
defective
in
Gaucher
(GD),
attempt
alleviate
neurological
symptoms
GD
mouse
that
models
type
3
disease,
i.e.
chronic
neuronopathic
juvenile
subtype.
Upon
injection
an
AAVrh10
(adeno-associated
virus,
serotype
rh10)
vector
containing
designed
GCase
(dGCase)
into
left
lateral
ventricle
Gba-/-;Gbatg
mice,
significant
improvement
body
weight
and
life-span
was
observed,
compared
same
with
wild
(wtGCase).
Moreover,
reduction
levels
glucosylceramide
(GlcCer),
increase
activity
were
seen
right
hemisphere
concomitantly
motor
function,
neuroinflammation
mRNA
various
genes
shown
previously
be
elevated
brain
forms
GD.
Together,
these
data
pave
way
possible
modified
proteins
lysosomal
storage
diseases
other
disorders.
Язык: Английский
lncRNA ADEPTR loss-of-function elicits sex-specific behavioral and spine deficits
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 26, 2024
Abstract
Activity-dependent
changes
in
neuronal
connections
are
fundamental
to
learning
and
long-term
memory
storage.
However,
the
precise
contribution
of
long
noncoding
RNAs
(lncRNAs)
these
modifications
remains
unclear.
In
this
study,
we
assessed
role
lncRNA
ADEPTR,
a
cAMP-modulated
localized
dendrites,
which
is
crucial
for
synapse
morphology.
By
generating
two
different
mouse
models—one
with
deletion
ADEPTR
(L-ADEPTR)
one
its
protein
interaction
region
(S-ADEPTR)—we
investigated
sex-specific
impacts
loss
function
on
learning,
memory,
dendritic
arborization,
Our
behavioral
analyses
revealed
reduction
anxiety
adult
male
mice,
while
remained
unaffected
both
models.
Systematic
evaluations
morphology
across
various
developmental
stages
(∼3-day-old
postnatal
cultures
14-
42-day-old
female
mice)
uncovered
substantial
deficits
architecture
S-
L-ADEPTR
cultures.
At
day
42,
contrast
their
counterparts,
mice
exhibited
significant
deficiency
thin
spines.
Additionally,
found
that
expression
plasticity-related
gene
BDNF,
immediate
early
cFOS
were
enhanced
cortex
hippocampus
suggesting
activation
compensatory
mechanism
protecting
against
deficits.
Collectively,
observations
underscore
shaping
behavior.
Язык: Английский
lncRNA ADEPTR Loss-of-Function Elicits Sex-Specific Behavioral and Spine Deficits
Опубликована: Янв. 1, 2024
Язык: Английский
[Plasma long noncoding RNA expression profiles in patients with Parkinson's disease and the role of lnc-CTSD-5:1 in a PD cell model: a ceRNA microarray-based study].
PubMed,
Год журнала:
2024,
Номер
44(11), С. 2146 - 2155
Опубликована: Ноя. 20, 2024
To
explore
the
key
genes
and
long
non-coding
RNAs
(lncRNAs)
associated
with
Parkinson's
disease
(PD).
Язык: Английский
RNA regulation in brain function and disease 2022 (NeuroRNA): A conference report
Frontiers in Molecular Neuroscience,
Год журнала:
2023,
Номер
16
Опубликована: Март 13, 2023
Recent
research
integrates
novel
technologies
and
methods
from
the
interface
of
RNA
biology
neuroscience.
This
advancing
integration
both
fields
creates
new
opportunities
in
neuroscience
to
deepen
understanding
gene
expression
programs
their
regulation
that
underlies
cellular
heterogeneity
physiology
central
nervous
system.
Currently,
transcriptional
can
be
studied
individual
neural
cell
types
health
disease.
Furthermore,
there
is
an
increasing
interest
application
neurology.
These
aspects
were
discussed
at
online
conference
was
shortly
named
NeuroRNA.
Язык: Английский