RNA regulation in brain function and disease 2022 (NeuroRNA): A conference report DOI Creative Commons
Monika Piwecka, Agnieszka Fiszer, Katarzyna Rolle

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2023, Volume and Issue: 16

Published: March 13, 2023

Recent research integrates novel technologies and methods from the interface of RNA biology neuroscience. This advancing integration both fields creates new opportunities in neuroscience to deepen understanding gene expression programs their regulation that underlies cellular heterogeneity physiology central nervous system. Currently, transcriptional can be studied individual neural cell types health disease. Furthermore, there is an increasing interest application neurology. These aspects were discussed at online conference was shortly named NeuroRNA.

Language: Английский

Small and long non-coding RNAs: Past, present, and future DOI
Ling‐Ling Chen, V. Narry Kim

Cell, Journal Year: 2024, Volume and Issue: 187(23), P. 6451 - 6485

Published: Nov. 1, 2024

Language: Английский

Citations

33
Synaptically-targeted long non-coding RNA SLAMR promotes structural plasticity by increasing translation and CaMKII activity DOI Creative Commons
Isabel Espadas, Jenna L. Wingfield, Yoshihisa Nakahata

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 27, 2024

Long noncoding RNAs (lncRNAs) play crucial roles in maintaining cell homeostasis and function. However, it remains largely unknown whether how neuronal activity impacts the transcriptional regulation of lncRNAs, or if this leads to synapse-related changes contributes formation long-term memories. Here, we report identification a lncRNA, SLAMR, which becomes enriched CA1-hippocampal neurons upon contextual fear conditioning but not CA3 neurons. SLAMR is transported along dendrites via molecular motor KIF5C recruited synapse stimulation. Loss function reduces dendritic complexity impairs activity-dependent spine structural plasticity translation. Gain contrast, enhances complexity, density, Analyses interactome reveal its association with CaMKIIα protein through 220-nucleotide element also involved transport. A CaMKII reporter reveals basal reduction loss-of-function. Furthermore, selective loss CA1 disrupts consolidation memory male mice, without affecting their acquisition, recall, extinction, spatial memory. Together, these results provide new functional insight into at fear.

Language: Английский

Citations

5
Targeting neuronal epigenomes for brain rejuvenation DOI Creative Commons
Sara Zocher

The EMBO Journal, Journal Year: 2024, Volume and Issue: 43(16), P. 3312 - 3326

Published: July 15, 2024

Abstract Aging is associated with a progressive decline of brain function, and the underlying causes possible interventions to prevent this cognitive have been focus intense investigation. The maintenance neuronal function over lifespan requires proper epigenetic regulation, accumulating evidence suggests that deterioration landscape contributes dysfunction during aging. Epigenetic aging neurons may, however, be malleable. Recent reports shown age-related changes in reversible targetable by rejuvenation strategies can restore This review discusses current identifies as driver promising target strategies, it highlights potential approaches for specific manipulation epigenome youthful state brain.

Language: Английский

Citations

3
Efficacy of an AAV vector encoding a thermostable form of glucocerebrosidase in alleviating symptoms in a Gaucher disease mouse model DOI Creative Commons
Ivan Milenković,

Shani Blumenreich,

Ariel Hochfelder

et al.

Gene Therapy, Journal Year: 2024, Volume and Issue: 31(9-10), P. 439 - 444

Published: Aug. 15, 2024

Almost all attempts to date at gene therapy approaches for monogenetic disease have used the amino acid sequences of natural protein. In current study, we use a designed, thermostable form glucocerebrosidase (GCase), enzyme defective in Gaucher (GD), attempt alleviate neurological symptoms GD mouse that models type 3 disease, i.e. chronic neuronopathic juvenile subtype. Upon injection an AAVrh10 (adeno-associated virus, serotype rh10) vector containing designed GCase (dGCase) into left lateral ventricle Gba

Language: Английский

Citations

1
Efficacy of an AAV vector encoding a thermostable form of glucocerebrosidase in alleviating symptoms in a Gaucher disease mouse model DOI Creative Commons
Anthony H. Futerman, Ivan Milenković,

Shani Blumenreich

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 19, 2024

Abstract Almost all attempts to date at gene therapy approaches for monogenetic disease have used the amino acid sequences of natural protein. In current study, we use a designed, thermostable form glucocerebrosidase (GCase), enzyme defective in Gaucher (GD), attempt alleviate neurological symptoms GD mouse that models type 3 disease, i.e. chronic neuronopathic juvenile subtype. Upon injection an AAVrh10 (adeno-associated virus, serotype rh10) vector containing designed GCase (dGCase) into left lateral ventricle Gba-/-;Gbatg mice, significant improvement body weight and life-span was observed, compared same with wild (wtGCase). Moreover, reduction levels glucosylceramide (GlcCer), increase activity were seen right hemisphere concomitantly motor function, neuroinflammation mRNA various genes shown previously be elevated brain forms GD. Together, these data pave way possible modified proteins lysosomal storage diseases other disorders.

Language: Английский

Citations

0
lncRNA ADEPTR loss-of-function elicits sex-specific behavioral and spine deficits DOI Creative Commons
Kaushik Chanda,

Jackson P. Carter,

Hirofumi Nishizono

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 26, 2024

Abstract Activity-dependent changes in neuronal connections are fundamental to learning and long-term memory storage. However, the precise contribution of long noncoding RNAs (lncRNAs) these modifications remains unclear. In this study, we assessed role lncRNA ADEPTR, a cAMP-modulated localized dendrites, which is crucial for synapse morphology. By generating two different mouse models—one with deletion ADEPTR (L-ADEPTR) one its protein interaction region (S-ADEPTR)—we investigated sex-specific impacts loss function on learning, memory, dendritic arborization, Our behavioral analyses revealed reduction anxiety adult male mice, while remained unaffected both models. Systematic evaluations morphology across various developmental stages (∼3-day-old postnatal cultures 14- 42-day-old female mice) uncovered substantial deficits architecture S- L-ADEPTR cultures. At day 42, contrast their counterparts, mice exhibited significant deficiency thin spines. Additionally, found that expression plasticity-related gene BDNF, immediate early cFOS were enhanced cortex hippocampus suggesting activation compensatory mechanism protecting against deficits. Collectively, observations underscore shaping behavior.

Language: Английский

Citations

0
lncRNA ADEPTR Loss-of-Function Elicits Sex-Specific Behavioral and Spine Deficits DOI
Kaushik Chanda, Jackson Carter, Hirofumi Nishizono

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
[Plasma long noncoding RNA expression profiles in patients with Parkinson's disease and the role of lnc-CTSD-5:1 in a PD cell model: a ceRNA microarray-based study]. DOI
Ren Zhang,

Peiyang Zhou,

Jinwei Tian

et al.

PubMed, Journal Year: 2024, Volume and Issue: 44(11), P. 2146 - 2155

Published: Nov. 20, 2024

To explore the key genes and long non-coding RNAs (lncRNAs) associated with Parkinson's disease (PD).

Language: Английский

Citations

0
RNA regulation in brain function and disease 2022 (NeuroRNA): A conference report DOI Creative Commons
Monika Piwecka, Agnieszka Fiszer, Katarzyna Rolle

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2023, Volume and Issue: 16

Published: March 13, 2023

Recent research integrates novel technologies and methods from the interface of RNA biology neuroscience. This advancing integration both fields creates new opportunities in neuroscience to deepen understanding gene expression programs their regulation that underlies cellular heterogeneity physiology central nervous system. Currently, transcriptional can be studied individual neural cell types health disease. Furthermore, there is an increasing interest application neurology. These aspects were discussed at online conference was shortly named NeuroRNA.

Language: Английский

Citations

1