Toxicology Mechanisms and Methods,
Год журнала:
2025,
Номер
unknown, С. 1 - 47
Опубликована: Май 28, 2025
Plastics
are
extensively
used
materials
with
a
long
environmental
lifespan,
posing
significant
risks
to
human
health
and
the
environment.
Global
plastic
consumption
has
surged,
waste
expected
triple
by
2060.
The
primary
concern
is
breakdown
of
plastics
into
nano
micro-sized
particles,
which
can
enter
body
have
been
detected
in
various
organs
tissues.This
review
systematically
examines
effects
micro
nanoplastics
(MNPs)
on
endocrine
system
using
vitro
vivo
experimental
models.
Following
PRISMA
guidelines,
articles
were
sourced
from
databases
like
PubMed,
Web
Science,
Scopus.
After
screening
for
relevance
removing
duplicates
non-English
articles,
103
focusing
MNPs
selected.MNPs
disrupt
functions,
altering
reproductive
hormones
gene
expression
patterns.
In
exposure
increases
inflammatory
markers
such
as
TNF-α,
IL-6,
IL-1β,
NF-κB,
leading
apoptosis,
inflammation,
oxidative
stress.
These
disruptions
impact
gonads,
thyroid
glands,
hormone
secretion
pituitary
hypothalamus.
Most
studies
focus
terrestrial
animals,
polystyrene
being
most
commonly
polymer.Future
research
should
explore
polymers,
longer
durations,
broader
range
concentrations,
human-level
better
understand
toxicity
particles.
Reducing
these
pollutants
requires
legal
changes,
consumer
behavior
adjustments,
increased
public
awareness.
Understanding
underlying
processes
help
propose
methods
mitigate
protect
health.
ACS Nano,
Год журнала:
2024,
Номер
18(4), С. 3733 - 3751
Опубликована: Янв. 22, 2024
Nanoplastics
(NPs),
as
emerging
pollutants,
have
attracted
global
attention.
Nevertheless,
the
adverse
effects
of
NPs
on
female
reproductive
health,
especially
unexplained
miscarriage,
are
poorly
understood.
Defects
trophoblast
cell
migration
and
invasion
associated
with
miscarriage.
Migrasomes
were
identified
cellular
organelles
largely
unidentified
functions.
Whether
might
affect
migration,
invasion,
migrasome
formation
induce
miscarriage
has
been
completely
unexplored.
In
this
study,
we
selected
polystyrene
nanoplastics
(PS-NPs,
50
nm)
a
model
plastic
particles
treated
human
cells
pregnant
mice
PS-NPs
at
doses
near
actual
environmental
exposure
in
humans.
We
found
that
to
induced
mouse
suppressed
ROCK1-mediated
migration/invasion
formation.
SOX2
was
transcription
factor
ROCK1.
activated
autophagy
promoted
degradation
SOX2,
thus
suppressing
SOX2-mediated
ROCK1
transcription.
Supplementing
murine
or
could
efficiently
rescue
alleviate
Analysis
protein
levels
ROCK1,
TSPAN4,
NDST1,
P62,
LC-3BII/I
PS-NP-exposed
cells,
villous
tissues
patients,
placental
gave
consistent
results.
Collectively,
study
revealed
toxicity
their
potential
regulatory
mechanism,
indicating
NP
is
risk
for
health.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
282, С. 116712 - 116712
Опубликована: Июль 15, 2024
Microplastics
(MPs)
have
emerged
as
widespread
environmental
pollutants,
causing
significant
threats
to
aquatic
ecosystems
and
organisms.This
review
examines
the
toxic
effects
of
MPs
on
fishes,
with
a
focus
neurobehavioural,
physiological,
reproductive
impacts,
well
underlying
mechanisms
toxicity.Evidence
indicates
that
induce
range
neurobehavioural
abnormalities
in
affecting
social
interactions
cognitive
functions.Altered
neurotransmitter
levels
are
identified
key
mechanism
driving
behavioural
alterations
following
MP
exposure.Physiological
fishes
exposed
also
reported,
including
neurotoxicity,
immunotoxicity,
oxidative
stress.These
physiological
disruptions
can
compromise
individual
health
organisms.Furthermore,
linked
exposure
discussed,
particular
emphasis
endocrine
signaling
pathways.These
impair
success
fish
species,
impacting
population
numbers.Here
we
explore
critical
role
mediating
after
MPs,
focusing
primarily
hypothalamic-pituitary-gonadal
axis.Our
highlights
urgent
need
for
interdisciplinary
research
efforts
aimed
at
elucidating
full
extent
toxicity
its
implications
ecosystems.Lastly,
identify
knowledge
gaps
future
research,
investigations
into
transgenerational
if
any,
quantifying
synergetic/antagonistic
other
pollutants.This
expanded
regarding
potential
risks
wildlife
is
expected
aid
policymakers
developing
mitigation
strategies
protect
species.
