The triple exposure nexus of microplastic particles, plastic-associated chemicals, and environmental pollutants from a human health perspective

Environment International, Год журнала: 2024, Номер 188, С. 108736 - 108736

Опубликована: Май 10, 2024

The presence of microplastics (MPs) is increasing at a dramatic rate globally, posing risks for exposure and subsequent potential adverse effects on human health. Apart from being physical objects, MP particles contain thousands plastic-associated chemicals (i.e., monomers, chemical additives, non-intentionally added substances) captured within the polymer matrix. These are often migrating MPs can be found in various environmental matrices food chains; health effects. In addition to attributes MPs, plastic surfaces effectively bind exogenous chemicals, including pollutants (e.g., heavy metals, persistent organic pollutants). Therefore, act as vectors pollution across air, drinking water, food, further amplifying posed by exposure. Critically, fragmentation plastics environment increases risk interactions with cells, available leach adsorb transfer pollutants. This review proposes so-called triple nexus approach comprehensively map existing knowledge interconnected particles, Based data, there large gap regard cumulative nexus. Each component known induce genotoxicity, inflammation, endocrine disruption, but about long-term inter-individual lacking. Furthermore, not readily excreted organisms after ingestion they have been accumulated blood, cardiac tissue, placenta, etc. Even though number studies MPs-associated impacts rapidly, this underscores that pressing necessity achieve an integrated assessment MPs' order address future gaps.

Язык: Английский

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Identification and quantification of nanoplastics (20–1000 nm) in a drinking water treatment plant using AFM-IR and Pyr-GC/MS

Journal of Hazardous Materials, Год журнала: 2023, Номер 463, С. 132933 - 132933

Опубликована: Ноя. 7, 2023

Язык: Английский

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Effects of microplastics on the kidneys: a narrative review

Kidney International, Год журнала: 2024, Номер 106(3), С. 400 - 407

Опубликована: Июнь 18, 2024

Язык: Английский

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Toxic effects of nanopolystyrene and cadmium on the intestinal tract of the Chinese mitten crab (Eriocheir sinensis)

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 270, С. 115936 - 115936

Опубликована: Янв. 1, 2024

Nanopolystyrene (NP) and cadmium (Cd) are ubiquitous contaminants in aquatic systems. The present study aimed to investigate the toxic effects of exposure ambient concentrations NP and/or Cd on intestinal tract Chinese mitten crab (Eriocheir sinensis). Exposure induced oxidative stress, as evidenced by a significant increase lipid peroxide content (LPO), total antioxidant capacity (T-AOC), peroxidase activity (POD), decreases superoxide dismutase (SOD) glutathione (GSH-PX) activities E. sinensis. In addition, imbalanced homeostasis microbiota, demonstrated significantly increased abundance Spiroplasma. Transcriptomic metabolomic analyses were performed mechanisms underlying toxicity. Our results showed that ferroptosis, ABC transporters, phosphotransferase system, apoptosis, leukocyte transendothelial migration disturbed after Cd. particular, affected mucin type O-glycan biosynthesis, purine metabolism, neuroactive ligand-receptor interaction. Intriguingly, co-exposure might mitigate toxicity decreasing stress affecting these pathways. Taken together, our clearly demonstrates at environmentally relevant causes

Язык: Английский

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Microplastics and nanoplastics in haemodialysis waters: Emerging threats to be in our radar

Environmental Toxicology and Pharmacology, Год журнала: 2023, Номер 102, С. 104253 - 104253

Опубликована: Авг. 20, 2023

Microplastics are present in the environment, drinking water, human blood and there is evidence of nanoplastics tap water. The objective this work was to analyze possibility hemodialysis patients being contaminated by micro (MNPs) during dialysis treatments. motivation for investigation fact that use about 300-600 L water per week, which may be MNPs. A literature review, a field London hospital an estimation MNPs intake were carried out. results showed potential points risk contamination hemodialysis. It also estimated filtration efficiency 99% MNPs, amount microplastics can penetrate kidneys 0.0021 3,768 particles/week. assessment concludes at high MNP contamination.

Язык: Английский

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The physiological effect of polystyrene nanoplastic particles on fish and human fibroblasts

The Science of The Total Environment, Год журнала: 2024, Номер 914, С. 169979 - 169979

Опубликована: Янв. 10, 2024

Numerous studies have identified the detrimental effects for biosphere of large plastic debris, effect microplastics (MPs) and nanoplastics (NPs) is less clear. The skin first point contact with NPs, fibroblasts a vital role in maintaining structure function. Here, comparative approach taken using three fibroblast cell lines from zebrafish (SJD.1), human male newborn (BJ-5ta) female adult (HDF/TERT164) their response to polystyrene NP (PS-NPs) exposure characterized. Cells were exposed environmentally relevant PS-NP sizes (50, 500 1000 nm) concentrations (0.001 10 μg/ml) uptake (1000 nm), on viability, proliferation, migration, reactive oxygen species (ROS) production, apoptosis, alkaline phosphatase (ALP) acid (AP) determined. All took up PS-NPs, relationship between particle size concentration inhibition proliferation migration was identified. inhibitory PS-NPs more pronounced fibroblasts. presence negatively affected time-, size- concentration-dependent manner larger at higher causing significant being most affected. No major changes detected ROS production or apoptosis challenged While ALP activity increased all lines, only fish showed increase AP activity. heterogeneous induced by clearly revealed segregation HDF, BJ.5ta SJD.1 principal component analysis. Our results demonstrate that adversely cellular processes cell-type dose-specific distinct emphasizing need further exploration interactions different types better understand potential implications health.

Язык: Английский

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Micro(nano)plastics: an Emerging Burden for Human Health

International Journal of Biological Sciences, Год журнала: 2024, Номер 20(14), С. 5779 - 5792

Опубликована: Окт. 21, 2024

The escalation of plastic pollution represents a global environmental and health problem. Important toxic effects have been attributed to the increasing diffusion microplastics (MPs) nanoplastics (NPs) derived from degradation plastics. These particles ubiquitously observed in environment, with humans being continuously exposed via ingestion, inhalation skin contact. Nonetheless, cellular homeostasis imbalance induced by micro- nano- plastics (MNPs) human has only recently shown, while most evidence molecular mechanisms studies

Язык: Английский

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Microcystins-Loaded Aged Nanoplastics Provoke a Metabolic Shift in Human Liver Cells

Environmental Science & Technology, Год журнала: 2023, Номер 57(29), С. 10521 - 10531

Опубликована: Июль 14, 2023

Studies concerning the toxicity of pollutant-loaded nanoplastics (NPs) toward humans are still in their infancy. Here, we evaluated adsorption microcystins (MCs) by pristine and aged polystyrene (PSNPs), prepared MCs-loaded PSNPS (1, 5, 10, 15, 19 μg/mg), systematically mapped key molecular changes induced PSNPs to human hepatoblastoma (HepG2) cells. According results, MC-LR is increased 2.64-fold aging, PSNP accumulation detected HepG2 The cytotoxicity MC-LR-loaded showed a positive relationship with amount, as cell viability μg/mg loading treatment (aPS-MC19) was 10.84% lower than PSNPs; meanwhile, more severe oxidative damage observed. Primary approaches involved stressing endoplasmic reticulum reducing protein synthesis that posed for cells, while aggravated aPS-MC19 combined result metabolic energy disorder, damage, stress, downregulation target protein. Our results confirm could bring into significantly interfere biological processes, provide new insight deciphering risk NPs humans.

Язык: Английский

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Combined exposure of nano‐titanium dioxide and polystyrene nanoplastics exacerbate oxidative stress‐induced liver injury in mice by regulating the Keap‐1/Nrf2/ARE pathway

Environmental Toxicology, Год журнала: 2024, Номер 39(5), С. 2681 - 2691

Опубликована: Янв. 17, 2024

Abstract It is well known that polystyrene nanoplastics (PS‐NaP) and nano‐titanium dioxide (TiO 2 NPs) are frequently co‐appeared in daily life can cause liver injury when they accumulate the liver. Nonetheless, combined toxicological impacts potential molecular mechanisms of PS‐NaP TiO NPs hepatic system have not been revealed. Thus, we conducted experiments on C57BL/6 mice exposed to or/and for 4 weeks. The findings suggested co‐exposed significantly altered function parameters, levels antioxidant‐related enzymes genes expression Keap‐1/Nrf2/ARE signaling pathway, as increased Ti contents, aggravated pathological oxidative stress (OS) damage compared with individual exposure or NPs. Using N‐Acetyl‐L‐cysteine (NAC), an OS inhibitor, further demonstrated played a pivotal role coexposure‐induced injury. NAC reduced mice, which mitigated co‐exposure‐induced Taken together, proposed activated Keap‐1 , then inhibited recognition Nrf2 ARE consequently exacerbated These shed light co‐toxicity mechanism nanoparticles, informed risk assessment human environmental pollutants.

Язык: Английский

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Polystyrene nanoplastics induce apoptosis of human kidney proximal tubular epithelial cells via oxidative stress and MAPK signaling pathways

Environmental Science and Pollution Research, Год журнала: 2023, Номер 30(51), С. 110579 - 110589

Опубликована: Окт. 4, 2023

Язык: Английский

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