Canonical
phototherapeutics
have
several
limitations,
including
a
lack
of
tumor
selectivity,
nondiscriminatory
phototoxicity,
and
hypoxia
aggravation.
The
microenvironment
(TME)
is
characterized
by
hypoxia,
acidic
pH,
high
levels
H2
O2
,
GSH,
proteases.
To
overcome
the
shortcomings
canonical
phototherapy
achieve
optimal
theranostic
effects
with
minimal
side
effects,
unique
TME
characteristics
are
employed
in
development
phototherapeutic
nanomedicines.
In
this
review,
effectiveness
three
strategies
for
developing
advanced
based
on
various
examined.
first
strategy
involves
targeted
delivery
to
tumors
assistance
TME-induced
nanoparticle
disassembly
or
surface
modification.
second
near-infrared
absorption
increase-induced
activation
triggered
factors.
third
enhancing
therapeutic
efficacy
ameliorating
TME.
functionalities,
working
principles,
significance
applications
highlighted.
Finally,
possible
challenges
future
perspectives
further
discussed.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(12), С. 3955 - 3972
Опубликована: Янв. 1, 2023
This
review
highlights
recent
advances
in
the
utilization
of
various
endogenous
and
exogenous
stimuli
to
activate
nanocarrier-based
ferroptosis
cancer
therapy
that
can
be
effective
treating
conventional
drug-resistant
tumors.
ACS Nano,
Год журнала:
2023,
Номер
17(12), С. 11492 - 11506
Опубликована: Июнь 7, 2023
Ferroptosis
therapy
(FT)
efficacy
of
tumors
suffers
from
a
relatively
low
concentration
Fenton
agents,
limited
hydrogen
peroxide
(H2O2)
content,
and
insufficient
acidity
in
the
tumor
environment
(TME),
which
are
unfavorable
for
reactive
oxygen
species
(ROS)
generation
based
on
or
Fenton-like
reactions.
The
glutathione
(GSH)
overexpression
TME
can
scavenge
ROS
abate
FT
performance.
In
this
study,
strategy
storm
specifically
initiated
by
our
developed
nanoplatforms
(TAF-HMON-CuP@PPDG)
is
proposed
high-performance
tumors.
GSH
initiates
HMON
degradation,
resulting
tamoxifen
(TAF)
copper
(CuP)
release
TAF3-HMON-CuP3@PPDG.
released
TAF
leads
to
enhanced
acidification
within
cells,
reacts
with
CuP
producing
Cu2+
H2O2.
reaction
between
H2O2
generates
Cu+,
that
Cu+
Cu2+,
forming
cyclic
catalysis
effect.
generate
GSSG.
increased
accelerate
consumption
decreases
peroxidase
4
(GPX4)
expression.
All
above
reactions
cells
FT,
demonstrated
cancer
tumor-bearing
mice.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(35)
Опубликована: Фев. 25, 2023
Abstract
Understanding
the
intricate
molecular
machinery
that
governs
ferroptosis
and
leveraging
this
accumulating
knowledge
could
facilitate
disease
prevention,
diagnosis,
treatment,
prognosis.
Emerging
approaches
for
in
situ
detection
of
major
regulators
biological
events
across
cellular,
tissue,
living
subjects
provide
a
multiscale
perspective
studying
ferroptosis.
Furthermore,
advanced
applications
integrate
latest
technologies
hold
tremendous
promise
research.
In
review,
we
first
briefly
summarize
mechanisms
key
underlying
Ferroptosis
are
then
presented
to
delineate
their
design,
action,
applications.
Special
interest
is
placed
on
multifunctional
platforms.
Finally,
discuss
prospects
challenges
applications,
with
aim
providing
roadmap
theranostic
development
broad
range
ferroptosis‐related
diseases.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(6), С. 3736 - 3747
Опубликована: Фев. 2, 2023
Ferroptosis,
a
newly
discovered
form
of
regulated
cell
death,
is
emerging
as
promising
approach
to
tumor
therapy.
However,
the
spatiotemporal
control
cell-intrinsic
Fenton
chemistry
modulate
ferroptosis
remains
challenging.
Here,
we
report
an
oxazine-based
activatable
molecular
assembly
(PTO-Biotin
Nps),
which
capable
triggering
lysosomal
dysfunction-mediated
pathway
with
excellent
resolution
via
near-infrared
(NIR)
light
evoke
ferroptosis.
In
this
system,
pH-responsive
NIR
photothermal
oxazine
molecule
was
designed
and
functionalized
tumor-targeting
hydrophilic
biotin-poly(ethylene
glycol)
(PEG)
chain
engineer
well-defined
nanostructured
assemblies
within
single-molecular
framework.
PTO-Biotin
Nps
possesses
selective
tropism
lysosome
accumulation
inside
cells,
accommodated
by
its
enhanced
activity
in
acidic
microenvironment.
Upon
activation,
promoted
dysfunction
induced
cytosolic
acidification
impaired
autophagy.
More
importantly,
photoactivation-mediated
found
markedly
enhance
cellular
reactions
ferroptosis,
thereby
improving
antitumor
efficacy
mitigating
systemic
side
effects.
Overall,
our
study
demonstrates
that
engineering
enables
modulation
intrinsic
mechanism,
offering
novel
strategy
for
development
metal-free
inducers
The
acidic
characteristic
of
the
tumor
site
is
one
most
well-known
features
and
provides
a
series
opportunities
for
cancer-specific
theranostic
strategies.
In
this
regard,
pH-responsive
nanoplatforms
that
integrate
diagnostic
therapeutic
capabilities
are
highly
developed.
fluidity
microenvironment
(TME),
with
its
temporal
spatial
heterogeneities,
makes
noninvasive
molecular
magnetic
resonance
imaging
(MRI)
technology
very
desirable
TME
constituents
developing
MRI-guided
tumor-specific
treatments.
Therefore,
various
MRI-based
strategies
which
employ
assorted
modes
have
been
drawn
up
more
efficient
cancer
therapy
through
raised
local
concentration
agents
in
pathological
tissues.
review,
we
summarize
mechanisms
organic
components
(including
polymers,
biological
molecules,
organosilicas)
as
well
inorganic
metal
coordination
compounds,
oxides,
salts)
nanoplatforms.
Furthermore,
review
designs
applications
diagnosis
treatment
cancer.
addition,
challenges
prospects
pH-responsiveness
discussed.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(18), С. 6447 - 6496
Опубликована: Янв. 1, 2023
This
review
highlights
the
use
of
nanoprobes
to
stratify
various
therapeutic
modalities
and
provides
an
outlook
on
challenges
future
directions
for
patient
stratification.
Experimental Hematology and Oncology,
Год журнала:
2023,
Номер
12(1)
Опубликована: Июль 27, 2023
Abstract
Background
Ferroptosis
is
a
regulated
cell
death
mode
triggered
by
iron-dependent
toxic
membrane
lipid
peroxidation.
As
novel
modality
that
morphologically
and
mechanistically
different
from
other
forms
of
death,
such
as
apoptosis
necrosis,
ferroptosis
has
attracted
extensive
attention
due
to
its
association
with
various
diseases.
Evidence
on
potential
therapeutic
strategy
accumulated
the
rapid
growth
research
targeting
for
tumor
suppression
in
recent
years.
Methods
We
summarize
currently
known
characteristics
major
regulatory
mechanisms
present
role
cellular
stress
responses,
including
ER
autophagy.
Furthermore,
we
elucidate
applications
radiotherapy
immunotherapy,
which
will
be
beneficial
exploring
new
strategies
clinical
treatment.
Result
conclusion
Based
specific
biomarkers
precise
patient-specific
assessment,
great
translated
into
practical
approaches
cancer
therapy,
significantly
contributing
prevention,
diagnosis,
prognosis,
treatment
cancer.
