World Journal of Clinical Cases,
Год журнала:
2021,
Номер
9(31), С. 9368 - 9375
Опубликована: Окт. 29, 2021
Major
depressive
disorder
(MDD)
is
a
multifactorial
disorder,
where
multiple
susceptibility
genes
interact
with
environmental
factors,
predisposing
individuals
to
the
development
of
illness.
In
this
article,
we
reviewed
different
gene
×
environment
interaction
(G×E)
studies
shifting
from
candidate
genome-wide
approach.
Among
childhood
adversities
and
stressful
life
events
have
been
suggested
exert
crucial
impacts
on
MDD.
Importantly,
diathesis-stress
conceptualization
G×E
has
challenged
by
differential
theory.
Finally,
summarized
several
limitations
how
future
might
reveal
complex
interactions
between
environments
in
Psychotherapy and Psychosomatics,
Год журнала:
2022,
Номер
91(4), С. 238 - 251
Опубликована: Янв. 1, 2022
Childhood
maltreatment
(CM)
is
linked
to
impairments
in
various
domains
of
social
functioning.
Here,
we
argue
that
it
critical
identify
factors
underlie
impaired
functioning
as
well
processes
mediate
the
beneficial
health
effects
positive
relationships
individuals
exposed
CM.
Key
research
recommendations
are
presented,
focusing
on:
(1)
identifying
attachment-related
alterations
specific
inter-
and
intrapersonal
(e.g.,
regulation
closeness
distance)
problems
broader
lack
perceived
support)
affected
by
CM;
(2)
internal
current
emotional
state)
external
situational
cultural
factors,
presence
close
others)
modulate
processes;
(3)
mechanisms
explain
intact
Methodological
include:
assessing
through
interactive
(close
to)
real-life
assessments
inside
outside
laboratory;
adopting
an
interdisciplinary,
lifespan
perspective
assess
processes,
using
multi-method
assessments;
establishing
global
collaborations
account
for
influences
on
enable
replications
across
laboratories
countries.
The
proposed
line
will
contribute
globally
develop
refine
interventions
prevent
CM
further
relationships,
which
-
likely
buffering
chronic
stress
corresponding
allostatic
load
foster
resilience
improve
mental
physical
health,
thereby
reducing
personal
suffering
societal
economic
costs
its
consequences.
Interventions
targeting
euthymia
psychological
well-being
promising
therapeutic
concepts
this
context.
PLoS ONE,
Год журнала:
2024,
Номер
19(1), С. e0295926 - e0295926
Опубликована: Янв. 10, 2024
Introduction
There
is
a
resurgence
of
interest
in
the
therapeutic
potential
psychedelic
substances
such
as
3,4-methylenedioxymethamphetamine
(MDMA).
Primary
findings
from
our
randomized,
double-blind,
placebo-controlled,
multi-site
Phase
3
clinical
trial
participants
with
severe
PTSD
(NCT03537014)
showed
that
MDMA-assisted
therapy
induced
significant
attenuation
Clinician-Administered
Scale
for
DSM-5
compared
to
Therapy
placebo.
Deficits
emotional
coping
skills
and
altered
self-capacities
constitute
major
obstacles
successful
completion
available
treatments.
The
current
analysis
evaluated
differential
effects
placebo
on
transdiagnostic
outcome
measures
explored
contribution
changes
self-experience
improvement
scores.
Methods
Participants
were
randomized
receive
manualized
either
MDMA
or
during
experimental
sessions
combination
preparation
9
integration
visits.
Symptoms
measured
at
baseline
2
months
after
last
session
using
20-item
Toronto
Alexithymia
(TAS-20),
26-item
Self
Compassion
(SCS),
63-item
Inventory
Altered
Self-Capacities
(IASC).
Results
90
dosed
(MDMA-assisted
therapy,
n
=
46;
placebo,
44);
84.4%
(76/90)
had
histories
developmental
trauma,
87.8%
(79/90)
suffered
multiple
traumas.
facilitated
statistically
greater
TAS-20,
SCS,
most
IASC
factors
interpersonal
conflicts;
idealization
disillusionment;
abandonment
concerns;
identity
impairment;
self-awareness;
susceptibility
influence;
affect
dysregulation;
instability;
skill
deficit;
tension
reduction
activities;
only
exception
was
diffusion.
Conclusion
Compared
positive
mental
processes
which
are
often
associated
poor
treatment
outcome.
This
provides
possible
window
into
understanding
psychological
capacities
by
agents
may
result
improvements
symptomatology.
Trauma Violence & Abuse,
Год журнала:
2022,
Номер
24(4), С. 2560 - 2580
Опубликована: Май 24, 2022
Although
empirical
evidence
has
confirmed
the
causal
relationship
between
childhood
maltreatment
and
depression,
findings
are
inconsistent
on
magnitude
of
effect
age
exposure
to
psychological
development.
This
systematic
review
with
meta-analysis
aims
comprehensively
synthesize
literature
depression
quantitatively
compare
sizes
across
groups.
Electronic
databases
grey
up
April
6th,
2022,
were
searched
for
English-language
studies.
Studies
included
if
they:
1)
provided
information
age;
2)
statistical
indicators
examine
depression.
Fifty-eight
articles
met
eligibility
criteria
in
meta-analyses.
Subgroup
analyses
conducted
based
subtypes
measurements
Any
kind
(correlation
coefficient
[r]
=
0.17,
95%
CI
0.15–0.18),
physical
abuse
(r
=0.13,
0.10–0.15),
sexual
0.18,
0.15–0.21),
emotional
CI=0.11–0.23),
neglect
0.08,
CI=0.06–0.11)
associated
an
increased
risk
Significant
differential
effects
found
groups
(Q
34.81,
p
<
0.001).
Age
middle
(6–13
years)
had
highest
followed
by
late
(12–19
early
(0–6
years).
Implications
provide
robust
support
targeting
victimized
children
all
ages
paying
closer
attention
those
effectively
reduce
Substance Abuse Research and Treatment,
Год журнала:
2023,
Номер
17
Опубликована: Янв. 1, 2023
Young
adulthood
is
a
transitional
period
between
adolescence
and
adulthood.
Due
to
the
unique
pressures
of
taking
on
new
social
role
associated
uncertainties,
young
adults
are
at
heightened
risk
for
drug
alcohol
use.
Furthermore,
adverse
childhood
experiences
(ACEs)
increases
likelihood
using
maladaptive
coping
strategies
such
as
substances
avoid
or
soothe
negative
emotions.
The
current
review
aimed
summarize
associations
exposure
ACEs
before
age
18
years
subsequent
use
ages
25
years.The
was
performed
in
accordance
with
2020
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses
(PRISMA)
guidelines.
literature
search
Web
Science,
PubMed,
PsycINFO
databases
conducted
February
2022.The
initial
yielded
7178
articles,
777
duplicates.
Consequently,
6401
titles
were
inspected
relevance.
After
reading
full
text,
88
articles
included
review.This
provides
clear
evidence
that
multiple
robust
factor
alcohol,
cannabis
other
drugs
by
adults.
Poor
self-regulation
identified
mechanisms
explaining
this
link;
however,
further
detailed
research
needed.
Developmental Psychobiology,
Год журнала:
2023,
Номер
65(4)
Опубликована: Март 22, 2023
Abstract
Decades
of
research
underscore
the
profound
impact
adversity
on
brain
and
behavioral
development.
Recent
theoretical
models
have
highlighted
importance
considering
specific
features
that
may
dissociable
effects
at
distinct
developmental
timepoints.
However,
existing
measures
do
not
query
these
dimensions
in
sufficient
detail
to
support
proliferation
this
approach.
The
Dimensional
Inventory
Stress
Trauma
Across
Lifespan
(DISTAL)
was
developed
with
aim
thoroughly
retrospectively
assess
timing,
severity
(of
exposure
reaction),
type,
persons
involved,
controllability,
predictability,
threat,
deprivation,
proximity,
betrayal,
discrimination
inherent
an
individual's
adversity.
Here,
we
introduce
instrument,
present
descriptive
statistics
drawn
from
a
sample
N
=
187
adults
who
completed
DISTAL,
provide
initial
information
about
its
psychometric
properties.
This
novel
measure
facilitates
expansion
focused
assessing
relative
key
behavior
across
Development and Psychopathology,
Год журнала:
2024,
Номер
unknown, С. 1 - 9
Опубликована: Фев. 28, 2024
Abstract
Dante
Cicchetti’s
remarkable
contributions
to
the
field
of
developmental
psychopathology
include
advancement
key
principles
such
as
interplay
typical
and
atypical
development,
multifinality
equifinality,
dynamic
processes
resilience,
integration
multiple
levels
analysis
into
theories.
In
this
paper
we
assert
that
person-centered
data
analytic
methods
are
particularly
well-suited
advancing
these
tenets
psychopathology.
We
illustrate
their
utility
with
a
brief
novel
empirical
study
focused
on
underlying
patterns
childhood
neuroendocrine
regulation
prospective
links
emerging
adult
functioning.
Results
indicate
profile
marked
by
high
diurnal
cortisol
paired
low
DHEA
was
uniquely
associated
more
adaptive
functioning
in
adulthood.
discuss
findings,
broadly,
within
future
Alcohol Clinical and Experimental Research,
Год журнала:
2023,
Номер
47(9), С. 1722 - 1735
Опубликована: Июль 10, 2023
Abstract
Background
Individuals
with
fetal
alcohol
spectrum
disorders
(FASD)
experience
heightened
rates
of
childhood
trauma
and
adversity.
Research
has
examined
the
negative
impact
adverse
experiences
have
on
developmental
outcomes.
This
study
aims
to
take
field
a
step
further
by
examining
details
traumatic
events,
including
duration,
perpetrator,
whether
event
significantly
impacted
child,
subtype.
Subtype
is
using
threat/deprivation
dimensions
their
relation
child
behavior
caregiver‐child
relationship.
Methods
A
sample
84
children
aged
4–12
FASD,
all
in
out‐of‐home
placements,
families
took
part
an
emotion
coaching
intervention
study.
At
baseline,
caregivers
completed
questionnaires
assessing
trauma,
regulation
behavior,
caregiver
socialization,
relationships.
We
used
analysis
covariance
examine
differing
impacts
threat,
deprivation,
combination
two
behavioral
outcomes,
while
controlling
for
age.
also
Pearson's
r
correlations,
age,
duration
threat
or
deprivation
exposure
was
related
Results
Descriptive
statistics
showed
that
87.5%
individuals
experienced
three
more
subtypes
trauma.
The
average
1.62
years,
mean
onset
3.94
years.
Biological
parents
were
most
common
perpetrator.
There
worse
relationship
outcomes
experiencing
demonstrated
longer
associated
greater
cognitive
difficulties.
Conclusions
found
unique
patterns
FASD
when
analyzing
through
framework.
both
leads
overall.
Additionally,
vital
surrounding
point
crucial
areas
intervention,
Behavioral Sciences,
Год журнала:
2024,
Номер
14(2), С. 115 - 115
Опубликована: Фев. 4, 2024
Childhood
maltreatment
is
the
strongest
predictor
of
psychopathology
and
personality
disorders
across
lifespan
strongly
associated
with
a
variety
psychological
problems,
namely,
mood
anxiety
disorders,
behavioral
substance
abuse,
aggression,
self-harm.
In
this
study,
we
aim
to
provide
comprehensive
picture
interplay
between
different
traits
psychopathy
distinct
dimensions
childhood
maltreatment,
emotion
regulation,
aggression.
Using
cross-sectional
design,
employed
correlational
network
analysis
explore
nomological
sample-based
estimate
population
parameters
reflecting
direction,
strength,
patterns
relationships
variables.
The
sample
consisted
846
adults
(71%
females)
who
completed
questionnaires
measuring
psychopathy,
results
highlight
that
disinhibition
are
closest
attributes
early
experiences
abuse
(but
not
neglect)
in
correlate
all
regulation
difficulties,
being
specifically
reactive
Neglect
was
unique
attribute
meanness,
widespread
correlations
difficulties
but
also
an
increased
ability
engage
goal-directed
behavior.
Physical
only
dimension
adversity
found
be
intercorrelated
boldness
emotional
psychopathic
trait.
No
significant
associations
were
boldness,
aggression
once
shared
variance
controlled.
These
discussed
terms
their
implication
for
research
clinical
practice.
Frontiers in Psychology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 20, 2022
Loneliness
has
been
described
as
endemic
among
young
people.
Such
feelings
of
social
isolation
'even
in
a
crowd'
are
likely
linked
to
adverse
early
life
experiences
that
serve
diminish
perceptions
support
and
intensify
negative
interactions.
It
was
suggested
the
present
series
survey
studies
childhood
abuse,
which
compromises
child's
sense
safety
relationships,
may
affect
processes
contribute
loneliness
adulthood.
Study
1
assessed
different
adult
relation
adults
(N
=
171).
Linear
regression
analyses
indicated
abuse
uniquely
associated
with
greater
loneliness,
this
relationship
partially
mediated
by
perceived
availability
support.
2
289)
forms
demonstrated
emotional
unique
predictor
fully
lower
or
value
connections
(social
connectedness)
more
frequent
unsupportive
interactions
friends.
3
evaluated
implications
age
occurrence
566).
Both
sexual
predicted
regardless
age;
recalled
have
occurred
at
very
ages
(0-5
years)
not
predictive
over
above
consideration
events
happened
older
childhood.
These
relationships
were
least
support,
connectedness,
case
Our
results
add
mounting
evidence
pointing
prevalence
links
shape
appraisals
safety,
value,
personal
worth
relationships.
Abstract
Background
Depression
among
adolescents
is
a
seriously
disabling
public
health
problem
with
an
extremely
high
prevalence.
Identifying
risk
factors
of
depression
at
early
stage
important
to
reduce
the
disease
burden.
Childhood
maltreatment
(CM)
one
major
for
depression.
The
key
mediating
processes
that
how
CM
affects
development
depression,
however,
still
need
further
clarification.
present
study
tested
effect
self-esteem,
internalizing
problems,
and
externalizing
problems
between
depressive
symptoms.
Potential
sex
differences
in
foregoing
associations
were
also
explored.
Methods
A
three-wave
longitudinal
was
carried
out
1,957
middle
school
students
from
69
classes
10
schools
Guangdong
province
China.
Data
collection
started
when
grades
7
(median
age:
13.0,
range:
11–18)
January
April
2019,
followed
up
once
year
thereafter.
Self-reported
CM,
symptoms,
other
demographics
collected.
multiple
serial
mediation
analysis
conducted.
Results
We
found
positively
related
subsequent
as
well
while
self-esteem
negatively
Serial
indicated
(mediator
1)
2)
sequentially
mediated
path
symptoms
overall
male
population.
Moreover,
mediator
2,
acted
partial
association
males,
whereas
played
complete
role
females.
Conclusion
Findings
revealed
influence
on
independent
role.
In
addition,
be
taken
into
consideration
designing
prevention
intervention
strategies,
given
different
psychosocial
boys
girls.