Microbiota and maintenance of skin barrier function

Science, Год журнала: 2022, Номер 376(6596), С. 940 - 945

Опубликована: Май 26, 2022

Human skin forms a protective barrier against the external environment and is our first line of defense toxic, solar, pathogenic insults. Our also defines outward appearance, protects internal tissues organs, acts as sensory interface, prevents dehydration. Crucial to skin's function colonizing microbiota, which provides protection pathogens, tunes immune responses, fortifies epithelium. Here we highlight recent advances in understanding how microbiota mediates multiple facets function. We discuss insights into pathological host-microbiota interactions implications for disorders distant organs. Finally, examine microbiota-based mechanisms can be targeted prevent or manage impaired wound healing.

Язык: Английский

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Staphylococcus epidermidis and its dual lifestyle in skin health and infection

Nature Reviews Microbiology, Год журнала: 2022, Номер 21(2), С. 97 - 111

Опубликована: Авг. 30, 2022

Язык: Английский

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Skin Barrier Function and the Microbiome

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(21), С. 13071 - 13071

Опубликована: Окт. 28, 2022

Human skin is the largest organ and serves as first line of defense against environmental factors. The human microbiota defined total microbial community that coexists in body, while microbiome refers to collective genome these microorganisms. Skin microbes do not simply reside on but interact with a variety ways, significantly affecting barrier function. Here, we discuss recent insights into symbiotic relationships between physical, chemical, innate/adaptive immunological ways. We gut-skin axis affects Finally, examine effects dysbiosis function role inflammatory diseases, such acne, atopic dermatitis, psoriasis. Microbiome cosmetics can help restore improve diseases.

Язык: Английский

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The Skin Microbiome: Current Landscape and Future Opportunities

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3950 - 3950

Опубликована: Фев. 16, 2023

Our skin is the largest organ of body, serving as an important barrier against harsh extrinsic environment. Alongside preventing desiccation, chemical damage and hypothermia, this protects body from invading pathogens through a sophisticated innate immune response co-adapted consortium commensal microorganisms, collectively termed microbiota. These microorganisms inhabit distinct biogeographical regions dictated by physiology. Thus, it follows that perturbations to normal homeostasis, occurs with ageing, diabetes disease, can cause microbial dysbiosis increase infection risk. In review, we discuss emerging concepts in microbiome research, highlighting pertinent links between cutaneous repair. Moreover, address gaps current knowledge highlight key areas requiring further exploration. Future advances field could revolutionise way treat associated ageing other pathologies.

Язык: Английский

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Advances in the human skin microbiota and its roles in cutaneous diseases

Microbial Cell Factories, Год журнала: 2022, Номер 21(1)

Опубликована: Авг. 29, 2022

Skin is the largest organ in human body, and interplay between environment factors skin leads to some diseases, such as acne, psoriasis, atopic dermatitis. As first line of immune defense, plays significant roles health via preventing invasion pathogens that heavily influenced by microbiota. Despite being a challenging niche for microbes, colonized diverse commensal microorganisms shape environment. The microbiota can affect health, its imbalance dysbiosis contribute diseases. This review focuses on advances our understanding interaction with skin. Moreover, potential diseases are described, key species highlighted. prevention, diagnosis treatment strategies microbe-related healthy diets, lifestyles, probiotics prebiotics, discussed. Strategies modulation using synthetic biology discussed an interesting venue optimization skin-microbiota interactions. In summary, this provides insights into recovery, interactions engineering/rebuilding

Язык: Английский

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Wound healing and microbiome, an unexpected relationship

Journal of the European Academy of Dermatology and Venereology, Год журнала: 2023, Номер 37(S3), С. 7 - 15

Опубликована: Янв. 13, 2023

Abstract Skin wounds are common and represent a major public health economical problem, with risks of complications significant negative impact on the quality life patients. Cutaneous wound healing is tightly regulated process resulting in restoration tissue integrity. Wound involves interaction several skin, immune vascular cells, growth factors cytokines. However, external actors can play an important role healing, such as skin microbiome, which microbial commensal collection bacteria, fungi viruses inhabiting skin. Indeed, recent advances have featured interactions, within environment, between different species host system. This article reviews relationship microbiome process. Although cutaneous potential entry site for infection, either detrimental or beneficial healing. Thus, targeting could essential part management.

Язык: Английский

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Why traditional herbal medicine promotes wound healing: Research from immune response, wound microbiome to controlled delivery

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 195, С. 114764 - 114764

Опубликована: Фев. 23, 2023

Язык: Английский

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Commensal Cutibacterium acnes induce epidermal lipid synthesis important for skin barrier function

Science Advances, Год журнала: 2023, Номер 9(33)

Опубликована: Авг. 18, 2023

Lipid synthesis is necessary for formation of epithelial barriers and homeostasis with external microbes. An analysis the response human keratinocytes to several different commensal bacteria on skin revealed that Cutibacterium acnes induced a large increase in essential lipids including triglycerides, ceramides, cholesterol, free fatty acids. A similar occurred mouse epidermis affected acne. Further showed this was mediated by short-chain acids produced dependent increased expression lipid genes glycerol-3-phosphate-acyltransferase-3. Inhibition or RNA silencing peroxisome proliferator-activated receptor-α (PPARα), but not PPARβ PPARγ, blocked response. The keratinocyte content improved innate barrier functions antimicrobial activity, paracellular diffusion, transepidermal water loss. These results reveal metabolites from common bacterium have previously unappreciated influence composition epidermal lipids.

Язык: Английский

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Bacterial Biofilm in Chronic Wounds and Possible Therapeutic Approaches

Biology, Год журнала: 2024, Номер 13(2), С. 109 - 109

Опубликована: Фев. 9, 2024

Wound repair and skin regeneration is a very complex orchestrated process that generally composed of four phases: hemostasis, inflammation, proliferation, remodeling. Each phase involves the activation different cells production various cytokines, chemokines, other inflammatory mediators affecting immune response. The microbial composition plays an important role in wound healing. Indeed, commensals are essential maintenance epidermal barrier function, regulation host response, protection from invading pathogenic microorganisms. Chronic wounds common considered major public health problem due to their difficult-to-treat features frequent association with challenging chronic infections. These infections can be tough manage ability some bacteria produce multicellular structures encapsulated into matrix called biofilms. bacterial species contained biofilm often different, as capability influence healing wounds. Biofilms are, fact, tolerant resistant antibiotics antiseptics, leading failure treatment. For these reasons, biofilms impede appropriate treatment and, consequently, prolong period. Hence, there urgent necessity deepen knowledge pathophysiology delayed develop more effective therapeutic approaches able restore tissue damage. This work covers wound-healing pathogenesis infected by biofilm-forming pathogens. An overview strategies counteract formation or destroy existing also provided.

Язык: Английский

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Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing

Frontiers in Pharmacology, Год журнала: 2024, Номер 14

Опубликована: Янв. 16, 2024

Topical drug delivery is widely used in various diseases because of the advantages not passing through gastrointestinal tract, avoiding irritation and hepatic first-pass effect, reaching lesion directly to reduce unnecessary adverse reactions. The skin helps organism defend itself against a huge majority external aggressions one most important lines defense body. However, skin’s strong barrier ability also obstacle effectiveness topical medications. Allowing bioactive, composition pass stratum corneum as needed reach target site essential need for exert its therapeutic effect. state barrier, choice system composition, individualized disease detection dosing planning influence Nowadays, enhancing transdermal absorption topically applied drugs hottest research area. first improve all drugs. Excessive enhances accumulation at non-target sites occurrence This paper introduces strategies from three perspectives: delivery, describes current status shortcomings research, provides new directions ideas research.

Язык: Английский

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